Breast-feeding and optimal visual development.

The goal of the present study was to determine whether dietary supply of omega-3 essential fatty acid (EFA) influences visual development in healthy pre-term and full-term infants. Visual status was examined in human milk-fed infants (ample dietary omega-3 EFA supply) and corn oil-based formula-fed infants (no dietary omega-3 EFA; standard formula prior to 1987). At 57 weeks postconception (4 months adjusted age), both pre-term and full-term human milk-fed infants had significantly better visual evoked potential (VEP) and forced-choice preferential-looking (FPL) acuity than formula-fed infants. Acuity was correlated with a dietary omega-3 sufficiency index from red blood cell membranes obtained at 57 weeks postconception. At 36 months, full-term human milk-fed children had significantly better random dot stereo acuity and letter matching ability than formula-fed children. Stereo acuity and performance on the letter matching test were correlated with a dietary omega-3 sufficiency index from red blood cell membranes obtained at 4 months. These results suggest that dietary omega-3 fatty acids play an important role in visual development.

[1]  W. Connor,et al.  n-3 fatty acids in the brain and retina: evidence for their essentiality. , 2009, Nutrition reviews.

[2]  S. Innis,et al.  Plasma and red blood cell fatty acids of low-birth-weight infants fed their mother's expressed breast milk or preterm-infant formula. , 1990, The American journal of clinical nutrition.

[3]  P. Rhodes,et al.  Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. , 1986, The American journal of clinical nutrition.

[4]  A. D. Smith,et al.  The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. , 1984, Biochimica et biophysica acta.

[5]  M. T. Clandinin,et al.  Fatty acid utilization in perinatal de novo synthesis of tissues. , 1981, Early human development.

[6]  E. Dratz,et al.  A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments. , 1979, Experimental eye research.

[7]  R. R. Brenner,et al.  Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids. , 1966, The Journal of biological chemistry.

[8]  Ida Mann,et al.  The Development of the Human Eye , 1928, Nature.

[9]  W. Swanson,et al.  Color vision screening of young children. , 1992, Journal of pediatric ophthalmology and strabismus.

[10]  N. Bazan The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology. , 1989, Progress in clinical and biological research.