Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability

OBJECTIVES: To establish the prevalence of sarcopenia in older Americans and to test the hypothesis that sarcopenia is related to functional impairment and physical disability in older persons.

[1]  W. Frontera,et al.  Strength conditioning in older men: skeletal muscle hypertrophy and improved function. , 1988, Journal of applied physiology.

[2]  S. Heymsfield,et al.  Epidemiology of sarcopenia among the elderly in New Mexico. , 1998, American journal of epidemiology.

[3]  A. Astrup,et al.  Obesity : Preventing and managing the global epidemic , 2000 .

[4]  M. Hamilton,et al.  Strength and aerobic training attenuate muscle wasting and improve resistance to the development of disability with aging. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[5]  S B Roberts,et al.  Exercise training and nutritional supplementation for physical frailty in very elderly people. , 1994, The New England journal of medicine.

[6]  D. Downham,et al.  Distribution of different fibre types in human skeletal muscles Fibre type arrangement in m. vastus lateralis from three groups of healthy men between 15 and 83 years , 1983, Journal of the Neurological Sciences.

[7]  Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94. Series 1: programs and collection procedures. , 1994, Vital and health statistics. Ser. 1, Programs and collection procedures.

[8]  J. Kehayias,et al.  Total body potassium and body fat: relevance to aging. , 1997, The American journal of clinical nutrition.

[9]  R. Roubenoff.  Origins and clinical relevance of sarcopenia. , 2001, Canadian journal of applied physiology = Revue canadienne de physiologie appliquee.

[10]  H. Lukaski,et al.  A simple, inexpensive method of determining total body water using a tracer dose of D2O and infrared absorption of biological fluids. , 1985, The American journal of clinical nutrition.

[11]  S. Katz.  Studies of illness in the aged , 1963 .

[12]  S. Z. Nagi.  An epidemiology of disability among adults in the United States. , 1976, The Milbank Memorial Fund quarterly. Health and society.

[13]  S. Katz,et al.  STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION. , 1963, JAMA.

[14]  P J Garry,et al.  Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. , 1997, Metabolism: clinical and experimental.

[15]  P. Wilson,et al.  Monocyte cytokine production in an elderly population: effect of age and inflammation. , 1998, The journals of gerontology. Series A, Biological sciences and medical sciences.

[16]  T. Bush,et al.  Self-report and medical record report agreement of selected medical conditions in the elderly. , 1989, American journal of public health.

[17]  T. Lohman,et al.  Anthropometric Standardization Reference Manual , 1988 .

[18]  M. Lawton,et al.  Assessment of older people: self-maintaining and instrumental activities of daily living. , 1969, The Gerontologist.

[19]  J. Compston,et al.  Assessment of fracture risk and its application to screening for postmenopausal osteoporosis (WHO Technical Report Series No 843) , 1995 .

[20]  W. O'Fallon,et al.  Epidemiology of Sarcopenia , 2000, Journal of the American Geriatrics Society.

[21]  L G Branch,et al.  Short‐Term Variability of Measures of Physical Function in Older People , 1990, Journal of the American Geriatrics Society.

[22]  J. Simard,et al.  DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging , 1998, Steroids.

[23]  Ronenn Roubenoff,et al.  From the Chicago MeetingsSarcopenia , 2001 .

[24]  R. Ross,et al.  Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. , 2000, Journal of applied physiology.

[25]  Treatment of Obesity in Adults.  Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health. , 1998, Obesity research.

[26]  R. Ross,et al.  Estimation of skeletal muscle mass by bioelectrical impedance analysis. , 2000, Journal of applied physiology.

[27]  S. Harlow,et al.  Agreement between questionnaire data and medical records. The evidence for accuracy of recall. , 1989, American journal of epidemiology.

[28]  H C Lukaski,et al.  Assessment of fat-free mass using bioelectrical impedance measurements of the human body. , 1985, The American journal of clinical nutrition.

[29]  J. Stoker,et al.  The Department of Health and Human Services. , 1999, Home healthcare nurse.

[30]  Ack,et al.  LOWER-EXTREMITY FUNCTION IN PERSONS OVER THE AGE OF 70 YEARS AS A PREDICTOR OF SUBSEQUENT DISABILITY , 2001 .

[31]  L. Launer,et al.  Body mass index, weight change, and risk of mobility disability in middle-aged and older women. The epidemiologic follow-up study of NHANES I. , 1994, JAMA.

[32]  I. Rosow,et al.  A Guttman health scale for the aged. , 1966, Journal of gerontology.

[33]  Suzanne G. Leveille,et al.  Midlife hand grip strength as a predictor of old age disability. , 1999, JAMA.

[34]  P. Gardiner,et al.  Long-term mild endurance exercise effects on the age-associated evolution of hindlimb muscle characteristics in hamsters , 1986, Mechanisms of Ageing and Development.

[35]  K. Westerterp.  Daily physical activity and ageing , 2000, Current opinion in clinical nutrition and metabolic care.

[36]  W F Brown,et al.  A method for estimating the number of motor units in thenar muscles and the changes in motor unit count with ageing , 1972, Journal of neurology, neurosurgery, and psychiatry.

[37]  W. Evans,et al.  Reversing sarcopenia: how weight training can build strength and vitality. , 1996, Geriatrics.

[38]  V. Young.  Amino acids and proteins in relation to the nutrition of elderly people. , 1990, Age and ageing.

[39]  J. Després,et al.  American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. , 1998, Medicine and science in sports and exercise.