(−)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase*
暂无分享,去创建一个
Hussein N. Rubaiy | Melanie J. Ludlow | David J. Beech | N. Vasudev | K. Muraki | Katsuhiko Muraki | Naveen S. Vasudev | D. Beech | M. J. Ludlow | Hannah J. Gaunt | Katie E. Musialowski | Nicola M. Blythe | H. Gaunt
[1] William J. Chain,et al. A brief synthesis of (-)-englerin A. , 2011, Journal of the American Chemical Society.
[2] K. Gustafson,et al. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. , 2009, Organic letters.
[3] L. Neckers,et al. Synthesis of a stable and orally bioavailable englerin analogue. , 2016, Bioorganic & medicinal chemistry letters.
[4] David Attwell,et al. Non-signalling energy use in the brain , 2015, The Journal of physiology.
[5] Herbert Waldmann,et al. (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. , 2015, Angewandte Chemie.
[6] W. Linehan,et al. Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality. , 2013, Cancer cell.
[7] D. Clapham,et al. TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain , 2001, Neuron.
[8] K. Kohn,et al. CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set. , 2012, Cancer research.
[9] B. Christensen,et al. Epigenetic silencing of Na,K-ATPase β1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma , 2014, Epigenetics.
[10] L. Vaca,et al. Regulation of the cellular localization and function of human transient receptor potential channel 1 by other members of the TRPC family. , 2008, Cell calcium.
[11] T. Gudermann,et al. Transient Receptor Potential Channel 1 (TRPC1) Reduces Calcium Permeability in Heteromeric Channel Complexes , 2011, The Journal of Biological Chemistry.
[12] T. Gudermann,et al. Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5* , 2000, The Journal of Biological Chemistry.
[13] Nathan T. Ross,et al. Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation , 2015, PloS one.
[14] N. Bander,et al. Reduced expression of beta-subunit of Na,K-ATPase in human clear-cell renal cell carcinoma. , 1999, The Journal of urology.
[15] C. Stournaras,et al. Na+/K+ ATPase inhibitors in cancer. , 2014, Current drug targets.
[16] Jing Li,et al. Natural and synthetic flavonoid modulation of TRPC5 channels , 2016, British journal of pharmacology.
[17] R. Fröhlich,et al. Total synthesis and biological evaluation of (-)-englerin A and B: synthesis of analogues with improved activity profile. , 2011, Angewandte Chemie.
[18] T. Gudermann,et al. Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator? , 2014, Cells.
[19] M. Schaefer,et al. TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. , 2003, Cell calcium.
[20] J. Beutler,et al. Synthesis and Biological Evaluation of New (−)‐Englerin Analogues , 2016, ChemMedChem.
[21] A. Cheong,et al. A Sphingosine-1–Phosphate–Activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility , 2006, Circulation research.
[22] L. Birnbaumer,et al. TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild‐type and TRPC1−/− mice , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[23] I. So,et al. Isoform- and receptor-specific channel property of canonical transient receptor potential (TRPC)1/4 channels , 2014, Pflügers Archiv: European Journal of Physiology.
[24] William C Reinhold,et al. CellMiner: a relational database and query tool for the NCI-60 cancer cell lines , 2009, BMC Genomics.