Synthesis and studies of biological activity of N-(4-tert-butylbenzyl)-N-(pyridin-3-ylmethyl)-2-aminothiazolines as potential multifunctional agents for treatment of neurodegenerative diseases

[1]  Petrie F. Roodbol.  Expert , 2018, Older People: Improving Health and Social Care.

[2]  R. Richardson,et al.  Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors. , 2016, Bioorganic & medicinal chemistry.

[3]  G. Aliev,et al.  Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease , 2015, Scientific Reports.

[4]  P. Taslimi,et al.  Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives. , 2015, Bioorganic chemistry.

[5]  Dawid Panek,et al.  Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer's Disease , 2014, Current medicinal chemistry.

[6]  O. Chupakhin,et al.  Alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates as new effective and selective inhibitors of carboxylesterase , 2015, Doklady Biochemistry and Biophysics.

[7]  S. Bachurin,et al.  N,N-disubstituted 2-aminothiazolines as new inhibitors of serine esterases , 2013, Doklady Biochemistry and Biophysics.

[8]  J. Marco-Contelles,et al.  The multifactorial nature of Alzheimer's disease for developing potential therapeutics. , 2013, Current topics in medicinal chemistry.

[9]  V. Tumiatti,et al.  Multifunctional tacrine derivatives in Alzheimer's disease. , 2013, Current topics in medicinal chemistry.

[10]  Vladimir A. Palyulin,et al.  Organophosphorus compound esterase profiles as predictors of therapeutic and toxic effects. , 2013, Chemico-biological interactions.

[11]  P. Potter,et al.  Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors. , 2013, Chemico-biological interactions.

[12]  V. A. Palyulin,et al.  Combined QSAR studies of inhibitor properties of O-phosphorylated oximes toward serine esterases involved in neurotoxicity, drug metabolism and Alzheimer's disease , 2012, SAR and QSAR in environmental research.

[13]  R. Richardson,et al.  Esterase profile of O-phosphorylated ethyltrifluorolactates in prediction of their therapeutic and toxic effects , 2012, Doklady Biochemistry and Biophysics.

[14]  P. Sharma,et al.  Thiazoles: having diverse biological activities , 2012, Medicinal Chemistry Research.

[15]  V. Andrisano,et al.  Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. , 2011, European journal of medicinal chemistry.

[16]  Erin E. Battin,et al.  Antioxidant Activity of Sulfur and Selenium: A Review of Reactive Oxygen Species Scavenging, Glutathione Peroxidase, and Metal-Binding Antioxidant Mechanisms , 2009, Cell Biochemistry and Biophysics.

[17]  Andrew Eisen,et al.  Amyotrophic lateral sclerosis: A 40-year personal perspective , 2009, Journal of Clinical Neuroscience.

[18]  A. Gaumont,et al.  Overview of the chemistry of 2-thiazolines. , 2009, Chemical reviews.

[19]  G. Makhaeva,et al.  Esterase profile and analysis of structure-inhibitor selectivity relationships for homologous phosphorylated 1-hydroperfluoroisopropanols , 2008, Doklady Biochemistry and Biophysics.

[20]  V. Menon,et al.  Antioxidant activity of an aminothiazole compound: possible mechanisms. , 2008, Chemico-biological interactions.

[21]  M. Decker,et al.  Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties. , 2008, Bioorganic & medicinal chemistry.

[22]  A. Roda,et al.  Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors. , 2008, European journal of medicinal chemistry.

[23]  Marek Bajda,et al.  Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment. , 2007, Current medicinal chemistry.

[24]  H. Tokuyama,et al.  Novel structural motifs consisting of chiral thiazolines: synthesis, molecular recognition, and anticancer activity. , 2007, Chemistry.

[25]  A. Stash,et al.  Synthesis of new 2-amino-5-hydroxymethyl-2-thiazolines , 2007 .

[26]  Ana Martínez,et al.  Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer’s disease , 2006, Expert opinion on investigational drugs.

[27]  Steven G Potkin,et al.  Targeting acetylcholinesterase and butyrylcholinesterase in dementia. , 2005, The international journal of neuropsychopharmacology.

[28]  Teruko Imai,et al.  Human carboxylesterase isozymes: catalytic properties and rational drug design. , 2006, Drug metabolism and pharmacokinetics.

[29]  N. Greig,et al.  Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent , 2005 .

[30]  Vincenza Andrisano,et al.  Rational approach to discover multipotent anti-Alzheimer drugs. , 2005, Journal of medicinal chemistry.

[31]  M. Smith,et al.  Oxidative stress mechanisms and potential therapeutics in Alzheimer disease , 2005, Journal of Neural Transmission.

[32]  E. Giacobini,et al.  Cholinesterase inhibitors: new roles and therapeutic alternatives. , 2004, Pharmacological research.

[33]  Fang Ke,et al.  Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives. , 2004, Bioorganic & medicinal chemistry.

[34]  K. Hensley,et al.  Oxidative stress in brain aging Implications for therapeutics of neurodegenerative diseases , 2002, Neurobiology of Aging.

[35]  Xiaoxiang Zhu,et al.  A New Therapeutic Target in Alzheimer's Disease Treatment: Attention to Butyrylcholinesterase , 2001, Current medical research and opinion.

[36]  C. Rice-Evans,et al.  Antioxidant activity applying an improved ABTS radical cation decolorization assay. , 1999, Free radical biology & medicine.

[37]  C. Berset,et al.  Use of a Free Radical Method to Evaluate Antioxidant Activity , 1995 .

[38]  F. Fonnum,et al.  A radiochemical assay method for carboxylesterase, and comparison of enzyme activity towards the substrates methyl [1-14C] butyrate and 4-nitrophenyl butyrate. , 1985, Biochemical pharmacology.

[39]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.

[40]  O. Gawron,et al.  Competitive inhibition of acetylcholinesterase by several thiazolines and oxazolines. , 1960, Archives of biochemistry and biophysics.