Time-frequency energy distribution of phrenic nerve discharges during aspiration reflex, cough and quiet inspiration

Aspiration reflex (AspR) represents a specific inspiratory motor behavior expressed by short, powerful inspiratory activity without subsequent active expiration and characterized by the ability to interrupt strong tonic inspiratory activity, as well as hypoxic apnea and several other functional disorders. Multiresolution analysis-based determination of spectral features arising during AspR has not yet been satisfactorily investigated. The time-frequency energy distribution of phrenic nerve electrical activity was compared during the AspR, inspiratory phase of tracheobronchial cough and quiet inspiration. Data obtained from 16 adult cats anesthetized with chloralose or pentobarbital were analyzed using a wavelet transformation, a sensitive method suitable for processing of the non-stationary respiratory output signal. Phrenic nerve energy was accumulated within lower frequency bands in AspR bursts. In AspR, higher frequencies contributed less to the total power, when compared to cough inspiration. Moreover, AspR indicated a stable time-frequency energy distribution, regardless of which of the two types of anesthesia were used. Chloralose anesthesia induced a decrease of parameters in cough and quiet inspiration related to the quantity of energy. The results indicate a specific method of information processing during generation of AspR, underlying its powerful ability to influence various severe functional disorders with potential implications for model experiments and clinical practice.

[1]  B. Thach,et al.  Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDS , 2003, Pediatric pulmonology.

[2]  Z. Tomori,et al.  Comparison of inspiratory effort in sniff-like aspiration reflex, gasping and normal breathing in cats. , 1993, The European respiratory journal.

[3]  Metin Akay,et al.  Investigating the complexity of respiratory patterns during the laryngeal chemoreflex , 2007, 2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine.

[4]  B. Nail,et al.  Patterns of spontaneous and reflexly-induced activity in phrenic and intercostal motoneurons , 2004, Experimental Brain Research.

[5]  J. Korpáš,et al.  Cough and Other Respiratory Reflexes , 1979 .

[6]  R. Beňačka,et al.  The sniff-like aspiration reflex evoked by electrical stimulation of the nasopharynx. , 1995, Respiration physiology.

[7]  Metin Akay,et al.  Hypoxia silences the neural activities in the early phase of the phrenic neurogram of eupnea in the piglet , 2005, Journal of NeuroEngineering and Rehabilitation.

[8]  E. Schuman,et al.  Frequency-Dependent Signal Transmission and Modulation by Neuromodulators , 2008, Front. Neurosci..

[9]  C N Christakos,et al.  Fast rhythms in phrenic motoneuron and nerve discharges. , 1991, Journal of neurophysiology.

[10]  H. Batsel,et al.  Bulbar respiratory neurons participating in the sniff reflex in the cat. , 1973, Experimental neurology.

[11]  K. Morris,et al.  Ventrolateral medullary respiratory network participation in the expiration reflex in the cat. , 2004, Journal of applied physiology.

[12]  M. I. Cohen,et al.  Neurogenesis of respiratory rhythm in the mammal. , 1979, Physiological reviews.

[13]  Amir-Homayoon Najmi,et al.  The Continuous Wavelet Transform and Variable Resolution Time-Frequency Analysis , 1997 .

[14]  Ziad S. Saad,et al.  Functional neuroanatomy of human voluntary cough and sniff production , 2007, NeuroImage.

[15]  Z. Tomori,et al.  Power spectral analysis of respiratory responses to pharyngeal stimulation in cats: comparisons with eupnoea and gasping. , 1995, The Journal of physiology.

[16]  B G Lindsey,et al.  Functional connectivity among ventrolateral medullary respiratory neurones and responses during fictive cough in the cat , 2000, The Journal of physiology.

[17]  B G Lindsey,et al.  Ventrolateral medullary respiratory network and a model of cough motor pattern generation. , 1998, Journal of applied physiology.

[18]  R. F. Rogers,et al.  Time-frequency coherence analysis of phrenic and hypoglossal activity in the decerebrate rat during eupnea, hyperpnea, and gasping. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[19]  K. Schmid,et al.  Involvement of fast synaptic inhibition in the generation of high-frequency oscillation in central respiratory system , 1989, Brain Research.

[20]  L. Rasmussen,et al.  Central nervous system dysfunction after anesthesia in the geriatric patient. , 2000, Anesthesiology clinics of North America.

[21]  Constantinos N. Christakos,et al.  High-frequency and medium-frequency components of different inspiratory nerve discharges and their modification by various inputs , 1987, Brain Research.

[22]  Z Tomori,et al.  Reversal of apnoea by aspiration reflex in anaesthetized cats. , 1991, The European respiratory journal.

[23]  Z. Tomori,et al.  Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of the respiratory tract , 1969, The Journal of physiology.

[24]  Jack L. Feldman,et al.  Neurophysiology of Breathing in Mammals , 1986 .

[25]  J. Leiter,et al.  Prolongation of the laryngeal chemoreflex after inhibition of the rostral ventral medulla in piglets: a role in SIDS? , 2003, Journal of applied physiology.

[26]  R. Vertes,et al.  Medium-frequency oscillations dominate the inspiratory nerve discharge of anesthetized newborn rats , 1999, Brain Research.

[27]  Medullary neuronal activities in gasping induced by pharyngeal stimulation and hypoxia. , 1995, Respiration physiology.

[28]  W. M. S. John,et al.  Reflex recruitment of medullary gasping mechanisms in eupnoea by pharyngeal stimulation in cats. , 1994, The Journal of physiology.

[29]  M. Misawa,et al.  Analysis of efferent discharges of the phrenic nerve during the cough reflex. , 1982, Japanese journal of pharmacology.

[30]  R. F. Rogers,et al.  Selective loss of high-frequency oscillations in phrenic and hypoglossal activity in the decerebrate rat during gasping. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[31]  Ki H Chon,et al.  Time-frequency representation of inspiratory motor output in anesthetized C57BL/6 mice in vivo. , 2005, Journal of neurophysiology.