Cathepsin K Deficiency in Pycnodysostosis Results in Accumulation of Non-Digested Phagocytosed Collagen in Fibroblasts

[1]  H. Birkedal‐Hansen,et al.  On the role of MT1-MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth. , 2002, European journal of oral sciences.

[2]  S. Goldring,et al.  Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. , 2002, Arthritis and rheumatism.

[3]  R. Gordon,et al.  Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation. , 2001, The American journal of pathology.

[4]  S. Landa,et al.  Maxillofacial alterations in a family with pycnodysostosis. , 2000, Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal.

[5]  D. Brömme,et al.  Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfates. , 2000, Biochemistry.

[6]  A. Roessner,et al.  Expression of cathepsin K in the human embryo and fetus , 1999, Developmental dynamics : an official publication of the American Association of Anatomists.

[7]  I. Kola,et al.  Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  E. Vuorio,et al.  Cathepsin expression during skeletal development. , 1999, Biochimica et biophysica acta.

[9]  J. Steinfort,et al.  Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[10]  H. Weinstein,et al.  Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis. , 1999, The Journal of clinical investigation.

[11]  Sheila J. Jones,et al.  Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Delaissé,et al.  Cysteine Proteinases and Matrix Metalloproteinases Play Distinct Roles in the Subosteoclastic Resorption Zone , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[13]  M. Brennan,et al.  Pycnodysostosis: orofacial manifestations in two pediatric patients. , 1998, Pediatric dentistry.

[14]  L. Creemers,et al.  Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants. , 1998, Matrix biology : journal of the International Society for Matrix Biology.

[15]  B. Gelb,et al.  Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency , 1996, Science.

[16]  L. Creemers,et al.  Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling , 1996, The Histochemical Journal.

[17]  D. Brömme,et al.  Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts , 1996, The Journal of Biological Chemistry.

[18]  N. Udagawa,et al.  An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions , 1995, Calcified Tissue International.

[19]  T. Muto,et al.  Pycnodysostosis. Report of a case and review of the Japanese literature, with emphasis on oral and maxillofacial findings. , 1991, Oral surgery, oral medicine, and oral pathology.

[20]  C. V. van Noorden,et al.  Selective inhibition of cysteine proteinases by Z-Phe-AlaCH2F suppresses digestion of collagen by fibroblasts and osteoclasts. , 1991, Biochemical and biophysical research communications.

[21]  R. H. Brown,et al.  Pycnodysostosis associated with delayed and ectopic eruption of permanent teeth. , 1991, International journal of paediatric dentistry.

[22]  V. Everts,et al.  Metalloproteinases are not involved in the phagocytosis of collagen fibrils by fibroblasts. , 1989, Matrix.

[23]  V. Everts,et al.  The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64. , 1985, Collagen and related research.

[24]  J. Delaissé,et al.  In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption. , 1984, Biochemical and biophysical research communications.

[25]  V. Everts,et al.  The site of remodelling of collagen in the periodontal ligament of the mouse incisor , 1977, The Anatomical record.

[26]  J. Sodek.  A comparison of the rates of synthesis and turnover of collagen and non-collagen proteins in adult rat periodontal tissues and skin using a microassay. , 1977, Archives of oral biology.