Optic cup segmentation from fundus images for glaucoma diagnosis

ABSTRACT Glaucoma is a serious disease that can cause complete, permanent blindness, and its early diagnosis is very difficult. In recent years, computer-aided screening and diagnosis of glaucoma has made considerable progress. The optic cup segmentation from fundus images is an extremely important part for the computer-aided screening and diagnosis of glaucoma. This paper presented an automatic optic cup segmentation method that used both color difference information and vessel bends information from fundus images to determine the optic cup boundary. During the implementation of this algorithm, not only were the locations of the 2 types of information points used, but also the confidences of the information points were evaluated. In this way, the information points with higher confidence levels contributed more to the determination of the final cup boundary. The proposed method was evaluated using a public database for fundus images. The experimental results demonstrated that the cup boundaries obtained by the proposed method were more consistent than existing methods with the results obtained by ophthalmologists.

[1]  Xu Sun,et al.  Feature Extraction from Optic Disc and Cup Boundary Lines in Fundus Images Based on ISNT Rule for Glaucoma Diagnosis , 2015 .

[2]  Giri Babu Kande,et al.  Segmentation of optic disk and optic cup from digital fundus images for the assessment of glaucoma , 2016, Biomed. Signal Process. Control..

[3]  Stephen Lin,et al.  Optic Cup Segmentation for Glaucoma Detection Using Low-Rank Superpixel Representation , 2014, MICCAI.

[4]  Jui-Kai Wang,et al.  Multimodal Segmentation of Optic Disc and Cup From SD-OCT and Color Fundus Photographs Using a Machine-Learning Graph-Based Approach , 2015, IEEE Transactions on Medical Imaging.

[5]  H. Quigley,et al.  The number of people with glaucoma worldwide in 2010 and 2020 , 2006, British Journal of Ophthalmology.

[6]  Bunyarit Uyyanonvara,et al.  Blood vessel segmentation methodologies in retinal images - A survey , 2012, Comput. Methods Programs Biomed..

[7]  H. Quigley Number of people with glaucoma worldwide. , 1996, The British journal of ophthalmology.

[8]  N. H. C. Yung,et al.  Curvature scale space corner detector with adaptive threshold and dynamic region of support , 2004, Proceedings of the 17th International Conference on Pattern Recognition, 2004. ICPR 2004..

[9]  Georg Michelson,et al.  Segmentation of Fundus Eye Images Using Methods of Mathematical Morphology for Glaucoma Diagnosis , 2004, International Conference on Computational Science.

[10]  Ana Maria Mendonça,et al.  Segmentation of retinal blood vessels by combining the detection of centerlines and morphological reconstruction , 2006, IEEE Transactions on Medical Imaging.

[11]  Tien Yin Wong,et al.  Superpixel Classification Based Optic Disc and Optic Cup Segmentation for Glaucoma Screening , 2013, IEEE Transactions on Medical Imaging.

[12]  Haizhou Li,et al.  Automated detection of kinks from blood vessels for optic cup segmentation in retinal images , 2009, Medical Imaging.

[13]  Jayanthi Sivaswamy,et al.  Optic disk and cup boundary detection using regional information , 2010, 2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro.

[14]  K. Yanashima,et al.  Development of a simple diagnostic method for the glaucoma using ocular Fundus pictures. , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[15]  Paolo Remagnino,et al.  BLOOD VESSEL SEGMENTATION METHODOLOGIES IN RETINAL IMAGES , 2012 .

[16]  Hiroshi Fujita,et al.  Improved automated optic cup segmentation based on detection of blood vessel bends in retinal fundus images , 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[17]  Baihua Li,et al.  Automatic extraction of retinal features from colour retinal images for glaucoma diagnosis: A review , 2013, Comput. Medical Imaging Graph..

[18]  Robert Ritch,et al.  The ISNT rule and differentiation of normal from glaucomatous eyes. , 2006, Archives of ophthalmology.

[19]  J. Liu,et al.  Level-set based automatic cup-to-disc ratio determination using retinal fundus images in ARGALI , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[20]  Dacheng Tao,et al.  Sparse Dissimilarity-Constrained Coding for Glaucoma Screening , 2015, IEEE Transactions on Biomedical Engineering.

[21]  Jayanthi Sivaswamy,et al.  1 & , 2001 .

[22]  James O. Ramsay,et al.  Applied Functional Data Analysis: Methods and Case Studies , 2002 .

[23]  Joachim Hornegger,et al.  The papilla as screening parameter for early diagnosis of glaucoma. , 2008, Deutsches Arzteblatt international.

[24]  Haizhou Li,et al.  ARGALI: an automatic cup-to-disc ratio measurement system for glaucoma detection and AnaLysIs framework , 2009, Medical Imaging.

[25]  Bram van Ginneken,et al.  Comparative study of retinal vessel segmentation methods on a new publicly available database , 2004, SPIE Medical Imaging.

[26]  Jayanthi Sivaswamy,et al.  Optic Disk and Cup Segmentation From Monocular Color Retinal Images for Glaucoma Assessment , 2011, IEEE Transactions on Medical Imaging.