THREAD (three-dimensional reconstruction and display) with biomedical applications in neuron ultrastructure and computerized tomography

THREAD is a computer system capable of displaying three-dimensional images from serial two-dimensional sections. The serial two-dimensional input images can either be in the format of 35 mm films or in digital cross sectional pictures of live patients generated by the ACTA (<b>A</b>utomatic <b>C</b>omputerized <b>T</b>ransverse <b>A</b>xial) Scanner. The hardware components of the system consists of FIDAC (<b>F</b>ilm <b>I</b>nput to <b>D</b>igital <b>A</b>utomatic <b>C</b>omputer), MACDAC (<b>MA</b>n <b>C</b>ommunication and <b>D</b>isplay to <b>A</b>utomatic <b>C</b>omputer), and the Display Subsystem of the ACTA-Scanner. The software includes such features as segmentation, rotation, hidden line removal, shading plane definition, shading and display. Two examples, one from serial electron micrographs of a neuron and the other from serial ACTA, live patient, scans are given to demonstrate the capability of the system.

[1]  B H BANG,et al.  Graphic reconstruction of the third dimension from serial electron microphotographs. , 1957, Journal of ultrastructure research.

[2]  John Edward Warnock,et al.  A hidden surface algorithm for computer generated halftone pictures , 1969 .

[3]  Robert F. Sproull,et al.  Principles in interactive computer graphics , 1973 .

[4]  H C Mitchell,et al.  Three Dimensions in Fine Structure , 1965, Science.

[5]  Raphael Poritsky,et al.  Two and three dimensional ultrastructure of boutons and glial cells on the motoneuronal surface in the cat spinal cord , 1969 .

[6]  W. M. Cowan,et al.  A computer system for the measurement of cell and nuclear sizes* , 1973, Journal of microscopy.

[7]  Robert S. Ledley,et al.  FIDAC - Film input to digital automatic computer , 1971, Pattern Recognit..

[8]  L Barajas,et al.  The ultrastructure of the juxtaglomerular apparatus as disclosed by three-dimensional reconstructions from serial sections. The anatomical relationship between the tubular and vascular components. , 1970, Journal of ultrastructure research.

[9]  Robert S. Ledley,et al.  Pattern recognition with interactive computing for a half dozen clinical applications of health care delivery , 1973, AFIPS National Computer Conference.

[10]  Gary S. Watkins,et al.  A real time visible surface algorithm , 1970 .

[11]  S J Dwyer,et al.  1975 Memorial Award Paper. Image generation and display techniques for CT scan data. Thin transverse and reconstructed coronal and sagittal planes. , 1975, Investigative radiology.

[12]  F. Sjöstrand.  Ultrastructure of retinal rod synapses of the guinea pig eye as revealed by three-dimensional reconstructions from serial sections. , 1958, Journal of ultrastructure research.

[13]  T J Willey,et al.  Computer graphics in three dimensions for perspective reconstruction of brain ultrastructure. , 1973, IEEE transactions on bio-medical engineering.

[14]  J C Mazziotta,et al.  A device for the precise transfer of serial sections for electron microscopy. , 1973, Stain technology.

[15]  F. S. Sjostrand.  Ultrastructure of retinal rod synapses of the guinea pig eye as revealed by three-dimensional reconstructions from serial sections. , 1958, Journal of ultrastructure research.

[16]  R L Schultz,et al.  Intranuclear inclusions in neurons of the cat primary olfactory system. , 1971, Brain research.

[17]  U Karlsson,et al.  Three-dimensional studies of neurons in the lateral geniculate nucleus of the rat. II. Environment of perikarya and proximal parts of their branches. , 1966, Journal of ultrastructure research.

[18]  F M Keddie,et al.  Three-dimensional reconstruction of Pityrosporum yeast cells based on serial section electron microscopy. , 1969, Journal of ultrastructure research.

[19]  U Karlsson,et al.  Three-dimensional studies of neurons in the lateral geniculate nucleus of the rat. I. Organelle organization in the perikaryon and its proximal branches. , 1966, Journal of ultrastructure research.

[20]  D F Wann,et al.  An on-line digital-computer system for the semiautomatic analysis of Golgi-impregnated neurons. , 1973, IEEE transactions on bio-medical engineering.

[21]  W. Jack Bouknight,et al.  A procedure for generation of three-dimensional half-toned computer graphics presentations , 1970, CACM.

[22]  P. Rakić.  Mode of cell migration to the superficial layers of fetal monkey neocortex , 1972, The Journal of comparative neurology.

[23]  R S Ledley,et al.  Three-dimensional image reconstruction from in vivo consecutive transverse axial sections. , 1975, Computers in biology and medicine.

[24]  R. Ledley.  Use of computers in biology and medicine , 1965 .

[25]  J. Bouknight,et al.  An Algorithm for Producing Half-Tone Computer Graphics Presentations With Shadows and Movable Light Sources , 1899 .

[26]  C. Levinthal,et al.  Structure and development of neuronal connections in isogenic organisms: variations and similarities in the optic system of Daphnia magna. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[27]  Lawrence G. Roberts,et al.  Machine Perception of Three-Dimensional Solids , 1963, Outstanding Dissertations in the Computer Sciences.

[28]  Edward P. Sayre,et al.  Computer-aided three-dimensional reconstruction and quantitative analysis of cells from serial electron microscopic montages of foetal monkey brain , 1974, Nature.

[29]  H. Gouraud.  Continuous Shading of Curved Surfaces , 1971, IEEE Transactions on Computers.

[30]  Ivan E. Sutherland,et al.  Sketchpad a man-machine graphical communication system , 1988, DAC 1988.

[31]  Robert F. Dunn.  Graphic three‐dimensional representations from serial sections * , 1972 .

[32]  Ivan E. Sutherland,et al.  Sketchpad a Man-Machine Graphical Communication System , 1899, Outstanding Dissertations in the Computer Sciences.

[33]  W. Glenn,et al.  Further investigation and initial clinical use of advanced CT display capability. , 1975, Investigative radiology.

[34]  Thomas J. Wright.  A Two-Space Solution to the Hidden Line Problem for Plotting Functions of Two Variables , 1973, IEEE Transactions on Computers.

[35]  Robert S. Ledley,et al.  Automatic computer measurements of neurons , 1968, Pattern Recognit..

[36]  R S Ledley,et al.  The ACTA-scanner: the whole body computerized transaxial tomograph. , 1974, Computers in biology and medicine.