Pregnant women’s perceptions of the COVID-19 vaccine: A French survey

Introduction Pregnant women are at increased risk for COVID-19, and COVID-19 vaccine is the most promising solution to overcome the current pandemic. This study was conducted to evaluate pregnant women’s perceptions and acceptance of COVID-19 vaccination. Materials & methods A cross-sectional study was conducted from February 18 to April 5 2021. An anonymous survey was distributed in 7 French obstetrics departments to all pregnant women before a prenatal visit. All pregnant women attending a follow-up consultation were asked to participate in the study. An anonymous web survey was available through a QR code and participants were asked whether or not they would agree to be vaccinated against SARS-CoV-2, and why. The questionnaire included questions on the patients’ demographics and their knowledge of COVID-19 vaccines. Results Of the 664 pregnant women who completed the questionnaire, 29.5% (95% CI 27.7; 31.3) indicated they would agree to be vaccinated against COVID-19. The main reason for not agreeing was being more afraid of potential side effects of the SARS-CoV-2 vaccine on the fetus than of COVID-19. Factors influencing acceptance of vaccination were: being slightly older, multiparity, having discussed it with a caregiver and acceptance of the influenza vaccine. Discussion Nearly one-third of pregnant women in this population would be willing to be vaccinated. In addition to studies establishing fetal safety, public health agencies and healthcare professionals should provide accurate information about the safety of COVID-19 vaccines.

[1]  A. Papageorghiou,et al.  Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection , 2021, JAMA pediatrics.

[2]  C. Olson,et al.  Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons , 2021, The New England journal of medicine.

[3]  V. Foulon,et al.  Vaccine Willingness and Impact of the COVID-19 Pandemic on Women’s Perinatal Experiences and Practices—A Multinational, Cross-Sectional Study Covering the First Wave of the Pandemic , 2021, International journal of environmental research and public health.

[4]  G. Rizzo,et al.  Pregnant women perspectives on SARS-COV-2 vaccine Condensation: Most of Italian pregnant women would not agree to get the SARS-COV-2 vaccine, irrespective of having features of high risk themselves, or being high-risk pregnancies. , 2021, American Journal of Obstetrics & Gynecology MFM.

[5]  S. Porat,et al.  Efficient maternofetal transplacental transfer of anti- SARS-CoV-2 spike antibodies after antenatal SARS-CoV-2 BNT162b2 mRNA vaccination , 2021, medRxiv.

[6]  G. Alter,et al.  Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study , 2021, American Journal of Obstetrics and Gynecology.

[7]  V. Male Are COVID-19 vaccines safe in pregnancy? , 2021, Nature Reviews Immunology.

[8]  S. Rasmussen,et al.  Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021. , 2021, JAMA.

[9]  S. Hernández-Díaz,et al.  COVID-19 vaccine acceptance among pregnant women and mothers of young children: results of a survey in 16 countries , 2021, European Journal of Epidemiology.

[10]  C. Heuser,et al.  Pregnant people deserve the protection offered by SARS-CoV-2 vaccines , 2020, Vaccine.

[11]  M. Daly,et al.  International estimates of intended uptake and refusal of COVID-19 vaccines: A rapid systematic review and meta-analysis of large nationally representative samples , 2020, Vaccine.

[12]  F. Figueras,et al.  Pregnant women with SARS‐CoV‐2 infection are at higher risk of death and pneumonia: propensity score matched analysis of a nationwide prospective cohort (COV19Mx) , 2020, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[13]  Heidi Ledford,et al.  The UK has approved a COVID vaccine — here’s what scientists now want to know , 2020, Nature.

[14]  H. Mercier,et al.  Sharp rise in vaccine hesitancy in a large and representative sample of the French population: reasons for vaccine hesitancy. , 2020 .

[15]  S. Chauhan,et al.  Rates of Maternal and Perinatal Mortality and Vertical Transmission in Pregnancies Complicated by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Co-V-2) Infection: A Systematic Review. , 2020, Obstetrics and gynecology.

[16]  A. Khalil,et al.  Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis , 2020, American Journal of Obstetrics & Gynecology MFM.

[17]  F. Goffinet,et al.  Trends in perinatal health in metropolitan France from 1995 to 2016: Results from the French National Perinatal Surveys. , 2017, Journal of gynecology obstetrics and human reproduction.

[18]  H. Larson,et al.  Understanding factors influencing vaccination acceptance during pregnancy globally: A literature review. , 2015, Vaccine.

[19]  U. Elkayam,et al.  Physiologic changes during normal pregnancy and delivery. , 2012, Cardiology clinics.

[20]  R. Crapo,et al.  Respiratory physiology of pregnancy , 2015, Breathe.

[21]  Gerhard A Zielhuis,et al.  Teratogenic mechanisms of medical drugs. , 2010, Human reproduction update.

[22]  B. Brenner Haemostatic changes in pregnancy. , 2004, Thrombosis research.

[23]  M. Frederiksen Physiologic changes in pregnancy and their effect on drug disposition. , 2001, Seminars in perinatology.