Opposing effects of aspirin and anticoagulants on morbidity and mortality in patients with upper gastrointestinal bleeding

We aimed to determine the effect of antithrombotics on in‐hospital mortality and morbidity in patients with peptic ulcer disease‐related upper gastrointestinal bleeding (PUD‐related UGIB).

[1]  O. Blatchford,et al.  Clinical outcome in upper gastrointestinal bleeding complicating low‐dose aspirin and antithrombotic drugs , 2006, Alimentary pharmacology & therapeutics.

[2]  E. Grossi,et al.  Mortality from nonulcer bleeding is similar to that of ulcer bleeding in high-risk patients with nonvariceal hemorrhage: a prospective database study in Italy. , 2011, Gastrointestinal endoscopy.

[3]  S. Hernández-Díaz,et al.  Risk of Upper Gastrointestinal Bleeding With Low-Dose Acetylsalicylic Acid Alone and in Combination With Clopidogrel and Other Medications , 2011, Circulation.

[4]  J. Tijssen,et al.  Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. , 2003, The American journal of gastroenterology.

[5]  J. Hallas,et al.  Use of single and combined antithrombotic therapy and risk of serious upper gastrointestinal bleeding: population based case-control study , 2006, BMJ : British Medical Journal.

[6]  J. Reitsma,et al.  Acute upper GI bleeding: did anything change? , 2003, American Journal of Gastroenterology.

[7]  V. Preedy,et al.  Prospective Cohort Study , 2010 .

[8]  V. Wong,et al.  Predicting mortality in patients with bleeding peptic ulcers after therapeutic endoscopy. , 2009, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[9]  J. Richter,et al.  Trends and Outcomes of Hospitalizations for Peptic Ulcer Disease in the United States, 1993 to 2006 , 2010, Annals of surgery.

[10]  N. Talley.  Continuation of Low-Dose Aspirin Therapy in Peptic Ulcer Bleeding: A Randomized Trial , 2010 .

[11]  V. Garrigues,et al.  Outcome of Non-Variceal Acute Upper Gastrointestinal Bleeding in Patients with Antithrombotic Therapy , 2009, Digestion.

[12]  P. Höglund,et al.  Mortality from peptic ulcer bleeding: the impact of comorbidity and the use of drugs that promote bleeding , 2010, Alimentary pharmacology & therapeutics.

[13]  Á. Lanas,et al.  Should Prophylactic Low-dose Aspirin Therapy be Continued in Peptic Ulcer Bleeding? , 2012, Drugs.

[14]  J. Sung,et al.  Causes of Mortality in Patients With Peptic Ulcer Bleeding: A Prospective Cohort Study of 10,428 Cases , 2010, The American Journal of Gastroenterology.

[15]  S. Travis,et al.  Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit , 2011, Gut.

[16]  K. Palmer,et al.  Acute gastrointestinal haemorrhage in anticoagulated patients: diagnoses and response to endoscopic treatment. , 1994, Gut.

[17]  H. Sørensen,et al.  Thirty-day mortality after peptic ulcer bleeding in hospitalized patients receiving low-dose aspirin at time of admission. , 2006, The American journal of geriatric pharmacotherapy.

[18]  D. Nelson,et al.  Acute GI bleeding in the setting of supratherapeutic international normalized ratio in patients taking warfarin: endoscopic diagnosis, clinical management, and outcomes. , 2003, Gastrointestinal endoscopy.

[19]  M. Pirmohamed,et al.  Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients , 2004, BMJ : British Medical Journal.

[20]  K. Mimidis,et al.  Acute upper gastrointestinal bleeding in patients on long-term oral anticoagulation therapy: endoscopic findings, clinical management and outcome. , 2005, World journal of gastroenterology.

[21]  V. Wong,et al.  High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers. , 2009, Gastroenterology.

[22]  Jana G Hashash,et al.  Gastrointestinal Bleeding in the Setting of Anticoagulation and Antiplatelet Therapy , 2009, Journal of clinical gastroenterology.

[23]  A. Chak,et al.  Lack of gender and racial differences in surgery and mortality in hospitalized medicare beneficiaries with bleeding peptic ulcer , 1997, Journal of General Internal Medicine.

[24]  R. Cestari,et al.  Predictive Factors of Mortality From Nonvariceal Upper Gastrointestinal Hemorrhage: A Multicenter Study , 2008, The American Journal of Gastroenterology.

[25]  J. Saltzman,et al.  Impact of Anticoagulation on Rebleeding Following Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Hemorrhage , 2006, The American Journal of Gastroenterology.

[26]  Á. Lanas,et al.  Clinical predictors of poor outcomes among patients with nonvariceal upper gastrointestinal bleeding in Europe , 2011, Alimentary pharmacology & therapeutics.

[27]  R. Cestari,et al.  Predicting Mortality in Non-Variceal Upper Gastrointestinal Bleeders: Validation of the Italian PNED Score and Prospective Comparison With the Rockall Score , 2010, The American Journal of Gastroenterology.

[28]  G. Sakellaropoulos,et al.  Changing Trends in the Epidemiology and Clinical Outcome of Acute Upper Gastrointestinal Bleeding in a Defined Geographical Area in Greece , 2008, Journal of clinical gastroenterology.