APAF-1 signaling in human melanoma.

[1]  M. D. Den Boer,et al.  Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia. , 2005, Blood.

[2]  C. Belka,et al.  Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection , 2005, Oncogene.

[3]  Amato J Giaccia,et al.  The role of p53 in hypoxia-induced apoptosis. , 2005, Biochemical and biophysical research communications.

[4]  D. Green,et al.  Apoptotic Pathways: Ten Minutes to Dead , 2005, Cell.

[5]  O. Cuvillier,et al.  Caspase-10 Triggers Bid Cleavage and Caspase Cascade Activation in FasL-induced Apoptosis* , 2005, Journal of Biological Chemistry.

[6]  T. Mak,et al.  Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis , 2005, Cell.

[7]  S. Orrenius,et al.  Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance. , 2005, Blood.

[8]  W. Sadee,et al.  ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. , 2005, Cancer research.

[9]  H. Pilch,et al.  Expression of Apaf-1 in cervical cancer correlates with lymph node metastasis but not with intratumoral hypoxia. , 2005, Gynecologic oncology.

[10]  R. Kim,et al.  Recent advances in understanding the cell death pathways activated by anticancer therapy , 2005, Cancer.

[11]  P. Clarke,et al.  Protein Kinase A Regulates Caspase-9 Activation by Apaf-1 Downstream of Cytochrome c* , 2005, Journal of Biological Chemistry.

[12]  Yigong Shi,et al.  Structure of the apoptotic protease-activating factor 1 bound to ADP , 2005, Nature.

[13]  M. Ueda,et al.  Decreased expression of Apaf-1 with progression of melanoma. , 2005, Pigment cell research.

[14]  D. Hoon,et al.  Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinoma , 2004, Oncogene.

[15]  M. Daniotti,et al.  Genetic progression of metastatic melanoma. , 2004, Cancer letters.

[16]  David Loegering,et al.  Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel , 2004, Clinical Cancer Research.

[17]  A. Anichini,et al.  Apoptosis Protease Activator Protein-1 Expression Is Dispensable for Response of Human Melanoma Cells to Distinct Proapoptotic Agents , 2004, Cancer Research.

[18]  T. Mak,et al.  Nucling Recruits Apaf-1/Pro-caspase-9 Complex for the Induction of Stress-induced Apoptosis* , 2004, Journal of Biological Chemistry.

[19]  T. Mak,et al.  Induced Inhibition of Ischemic/Hypoxic Injury by APIP, a Novel Apaf-1-interacting Protein* , 2004, Journal of Biological Chemistry.

[20]  G. Kroemer,et al.  Nuclear Localization of Apoptosis Protease Activating Factor-1 Predicts Survival after Tumor Resection in Early-Stage Non–Small Cell Lung Cancer , 2004, Clinical Cancer Research.

[21]  M. Martinka,et al.  Reduced Apaf-1 expression in human cutaneous melanomas , 2004, British Journal of Cancer.

[22]  M. Pierotti,et al.  BRAF alterations are associated with complex mutational profiles in malignant melanoma , 2004, Oncogene.

[23]  E. Borden,et al.  Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis , 2004, Cell Death and Differentiation.

[24]  Tak W. Mak,et al.  Pathways of apoptotic and non-apoptotic death in tumour cells , 2004, Nature Reviews Cancer.

[25]  D. Vaux,et al.  Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die , 2004, The Journal of cell biology.

[26]  D. Elashoff,et al.  Allelic Imbalance on 12q22-23 in Serum Circulating DNA of Melanoma Patients Predicts Disease Outcome , 2004, Cancer Research.

[27]  D. Elashoff,et al.  Allelic Imbalance of 12q22–23 Associated with APAF-1 Locus Correlates with Poor Disease Outcome in Cutaneous Melanoma , 2004, Cancer Research.

[28]  G. Botti,et al.  Analysis of APAF‐1 expression in human cutaneous melanoma progression , 2004, Experimental dermatology.

[29]  T. Mak,et al.  Coupling of caspase‐9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell‐type‐specific , 2004, The EMBO journal.

[30]  S. Korsmeyer,et al.  Cell Death Critical Control Points , 2004, Cell.

[31]  G. Shore,et al.  Regulation of apoptosis by endoplasmic reticulum pathways , 2003, Oncogene.

[32]  O. Tachibana,et al.  Frequent LOH at Chromosome 12q22‐23 and Apaf‐1 Inactivation in Glioblastoma , 2003, Brain pathology.

[33]  Gang Li,et al.  Tissue-specific regulation of Apaf-1 expression by p53. , 2003, Oncology reports.

[34]  M. Lanotte,et al.  Apoptosome-independent Pathway for Apoptosis , 2003, Journal of Biological Chemistry.

[35]  L. Chin The genetics of malignant melanoma: lessons from mouse and man , 2003, Nature Reviews Cancer.

[36]  Z. Ronai,et al.  Death receptors and melanoma resistance to apoptosis , 2003, Oncogene.

[37]  F. Haluska,et al.  PTEN signaling pathways in melanoma , 2003, Oncogene.

[38]  S. Lowe,et al.  Apoptosis and melanoma chemoresistance , 2003, Oncogene.

[39]  P. Hersey,et al.  Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria , 2003, Oncogene.

[40]  L. Frati,et al.  Survivin, bcl-2, bax, and bcl-X gene expression in sentinel lymph nodes from melanoma patients. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  N. Chandel,et al.  Oxygen deprivation induced cell death: An update , 2002, Apoptosis.

[42]  Keisuke Kuida,et al.  Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome , 2002, Nature.

[43]  Ximena Opitz-Araya,et al.  Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization , 2002, Science.

[44]  C. Sawyers,et al.  The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.

[45]  P. Krammer,et al.  Tumor Immunology , 2018, Medical Immunology.

[46]  Xuejun Jiang,et al.  Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. , 2002, Molecular cell.

[47]  Yuri Lazebnik,et al.  Identification of Omi/HtrA2 as a Mitochondrial Apoptotic Serine Protease That Disrupts Inhibitor of Apoptosis Protein-Caspase Interaction* , 2002, The Journal of Biological Chemistry.

[48]  P. Hersey,et al.  Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria. , 2001, Cancer research.

[49]  C. Harris,et al.  APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis. , 2001, Cancer research.

[50]  R. Larsson,et al.  Characteristics of etoposide-induced apoptotic cell death in the U-937 human lymphoma cell line , 2001, Anti-cancer drugs.

[51]  N Cascinelli,et al.  Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[52]  Martin F. Mihm,et al.  Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[53]  S. Srinivasula,et al.  Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells. , 2001, Blood.

[54]  A. Asai,et al.  Co‐transduction of Apaf‐1 and Caspase‐9 Augments Etoposide‐induced Apoptosis in U‐373MG Glioma Cells , 2001, Japanese journal of cancer research : Gann.

[55]  A. Godzik,et al.  A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis* , 2001, The Journal of Biological Chemistry.

[56]  A. Newland,et al.  Apaf-1XL is an inactive isoform compared with Apaf-1L. , 2001, Biochemical and biophysical research communications.

[57]  G. Kroemer,et al.  Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis , 2001, Oncogene.

[58]  S. B. Bratton,et al.  Recruitment, activation and retention of caspases‐9 and ‐3 by Apaf‐1 apoptosome and associated XIAP complexes , 2001, The EMBO journal.

[59]  D. Vaux,et al.  Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9 , 2001, The Journal of cell biology.

[60]  W. Gerald,et al.  Inactivation of the apoptosis effector Apaf-1 in malignant melanoma , 2001, Nature.

[61]  G. Salvesen,et al.  ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas , 2000, Current Biology.

[62]  Guido Kroemer,et al.  Hsp27 negatively regulates cell death by interacting with cytochrome c , 2000, Nature Cell Biology.

[63]  S. Srinivasula,et al.  Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90 , 2000, The EMBO journal.

[64]  Emad S. Alnemri,et al.  Negative regulation of the Apaf-1 apoptosome by Hsp70 , 2000, Nature Cell Biology.

[65]  Dick D. Mosser,et al.  Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome , 2000, Nature Cell Biology.

[66]  Xiaodong Wang,et al.  Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.

[67]  G. Núñez,et al.  Expression and Functional Analysis of Apaf-1 Isoforms , 2000, The Journal of Biological Chemistry.

[68]  Junying Yuan,et al.  Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β , 2000, Nature.

[69]  H. Stein,et al.  Three new types of Apaf-1 in mammalian cells. , 1999, Biochemical and biophysical research communications.

[70]  Seamus J. Martin,et al.  Regulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region* , 1999, The Journal of Biological Chemistry.

[71]  P. Hersey,et al.  Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. , 1999, Cancer research.

[72]  X. Liu,et al.  An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9* , 1999, The Journal of Biological Chemistry.

[73]  S. Lowe,et al.  Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. , 1999, Science.

[74]  Francesco Cecconi,et al.  Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development , 1998, Cell.

[75]  T. Mak,et al.  Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development , 1998, Cell.

[76]  S. Srinivasula,et al.  Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. , 1998, Molecular cell.

[77]  S. Srinivasula,et al.  Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade , 1997, Cell.

[78]  Xiaodong Wang,et al.  Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 , 1997, Cell.

[79]  Margot Thome,et al.  Inhibition of death receptor signals by cellular FLIP , 1997, Nature.

[80]  P. Galle,et al.  Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. , 1997, The Journal of clinical investigation.

[81]  M. Hengartner,et al.  Caenorhabditis elegans gene ced-9 protects cells from programmed cell death , 1992, Nature.

[82]  H. Horvitz,et al.  The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. , 1990, Developmental biology.

[83]  R. Seale Studies on the mode of segregation of histone nu bodies during replication in HeLa cells , 1976, Cell.

[84]  L. Altucci,et al.  ERRATUM: Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway , 2005, Nature Medicine.

[85]  Lucia Altucci,et al.  Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway , 2005, Nature Medicine.