MXene catalytic amplification-fluorescence/absorption dimode aptamer sensor for the detection of trace Pb2+ in milk

Lead ion (Pb2+) is a toxic heavy metal, which is very harmful to organisms. Therefore, the establishment of a rapid, simple, and sensitive method is of great significance to food safety and human health. It was found that MXeneTi3C2 nanosheet (NS) has a strong catalytic effect on the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) via H2O2 to form the oxidized product (TMBOX); it has a strong fluorescence peak at 415 nm and an absorption (Abs) peak at 295 nm. The aptamer of Pb2+ (Aptpb) can be adsorbed on the surface of an NS to form MXene-Apt conjugates, which reduces its catalytic active sites and inhibits its catalytic activity. When the target Pb2+ is added, it specifically binds with Aptpb to release MXene NSs to enhance the dimode signals. Therefore, a new MXene catalytic fluorescence/absorption dimode aptamer biosenering platform was fabricated for the determination of trace Pb2+ in milk and water samples, with the fluorescence assay linear range (LR) of 5.0 × 10−2-2.0 nmol/L.

[1]  Jinling Shi,et al.  Highly catalysis amplification of MOFNd-loaded nanogold combined with specific aptamer SERS/RRS assay of trace glyphosate. , 2022, The Analyst.

[2]  Shao-pu Liu,et al.  Absorption and Resonance Rayleigh Scattering Spectra of Ag(I) and Erythrosin System and Their Analytical Application in Food Safety , 2022, Frontiers in Nutrition.

[3]  X. Su,et al.  Label-free and dual-mode biosensor for HPV DNA based on DNA/silver nanoclusters and G-quadruplex/hemin DNAzyme. , 2022, Talanta.

[4]  R. Ghanbari,et al.  A novel signal amplification tag to develop rapid and sensitive aptamer-based biosensors. , 2022, Bioelectrochemistry.

[5]  Yong Huang,et al.  A fluorescence aptasensor based on GSH@GQDs and RGO for the detection of Glypican-3. , 2021, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[6]  Baoshan He,et al.  A fluorescent aptasensor for Pb2+ detection based on gold nanoflowers and RecJf exonuclease-induced signal amplification. , 2021, Analytica chimica acta.

[7]  Ai-hui Liang,et al.  A New Covalent Organic Framework of Dicyandiamide-Benzaldehyde Nanocatalytic Amplification SERS/RRS Aptamer Assay for Ultratrace Oxytetracycline with the Nanogold Indicator Reaction of Polyethylene Glycol 600 , 2021, Biosensors.

[8]  Jiefang Sun,et al.  Duplexed aptamer-isothermal amplification-based nucleic acid-templated copper nanoparticles for fluorescent detection of okadaic acid , 2021, Sensors and Actuators B: Chemical.

[9]  Jingjing Li,et al.  A novel small molecular liquid crystal catalytic amplification-nanogold SPR aptamer absorption assay for trace oxytetracycline. , 2021, Talanta.

[10]  Wei-Hao Huang,et al.  A Microfluidic Aptamer-Based Sensor for Detection of Mercury(II) and Lead(II) Ions in Water , 2021, Micromachines.

[11]  Xueqi Fu,et al.  2D titanium carbide nanosheets based fluorescent aptasensor for sensitive detection of thrombin. , 2021, Talanta.

[12]  Cuiling Zhang,et al.  Dual‐Ligand Functionalized Ag 2 S Quantum Dots for Turn‐On Detection of Lead (II) Ions in Mineral Samples Based on Aggregation‐Induced Enhanced Emission , 2021 .

[13]  Zhiliang Jiang,et al.  A simple SPR absorption method for ultratrace Pb2+ based on DNAzyme-COFPd nanocatalysis of Ni-P alloy reaction , 2021 .

[14]  Smita S. Kumar,et al.  Lead Toxicity: Health Hazards, Influence on Food Chain, and Sustainable Remediation Approaches , 2020, International journal of environmental research and public health.

[15]  Baoxin Li,et al.  A fluorometric aptamer-based assay for ochratoxin A by using exonuclease III-assisted recycling amplification , 2019, Microchimica Acta.

[16]  Chunhua Yang,et al.  A spectrophotometric method for simultaneous determination of trace ions of copper, cobalt, and nickel in the zinc sulfate solution by ultraviolet-visible spectrometry. , 2019, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[17]  Xiaoxiao Dong,et al.  Highly fluorescent Ti3C2 MXene quantum dots for macrophage labeling and Cu2+ ion sensing. , 2019, Nanoscale.

[18]  Yuanhong Xu,et al.  One-step hydrothermal synthesis of fluorescent MXene-like titanium carbonitride quantum dots , 2019, Inorganic Chemistry Communications.

[19]  T. Xue,et al.  SERS detection of mercury (II)/lead (II): A new class of DNA logic gates. , 2019, Talanta.

[20]  R. Singhal,et al.  Ultra-small two dimensional MXene nanosheets for selective and sensitive fluorescence detection of Ag+ and Mn2+ ions , 2019, Colloids and Surfaces A: Physicochemical and Engineering Aspects.

[21]  D. Prabhakaran,et al.  Dynamically modified C18 silica monolithic column for the rapid determinations of lead, cadmium and mercury ions by reversed-phase high-performance liquid chromatography. , 2018, Journal of chromatography. A.

[22]  Yuan Ding,et al.  Development of an upconversion fluorescence DNA probe for the detection of acetamiprid by magnetic nanoparticles separation. , 2018, Food chemistry.

[23]  G. Shankarling,et al.  A simple substituted spiropyran acting as a photo reversible switch for the detection of lead (Pb2+) ions , 2018 .

[24]  Yong Wang,et al.  Recent advance in MXenes: A promising 2D material for catalysis, sensor and chemical adsorption , 2017 .

[25]  Yury Gogotsi,et al.  2D metal carbides and nitrides (MXenes) for energy storage , 2017 .

[26]  Jian Zhu,et al.  Colorimetric detection of lead(II) ions based on accelerating surface etching of gold nanorods to nanospheres: the effect of sodium thiosulfate , 2016 .

[27]  F. Huang,et al.  ZnO nanoflower-based photoelectrochemical DNAzyme sensor for the detection of Pb2+. , 2014, Biosensors & bioelectronics.

[28]  Julong He,et al.  MXene: a new family of promising hydrogen storage medium. , 2013, The journal of physical chemistry. A.

[29]  Chih-Ching Huang,et al.  Colorimetric assay for lead ions based on the leaching of gold nanoparticles. , 2009, Analytical chemistry.