A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

[1]  G. Ramm,et al.  INPP5E regulates phosphoinositide-dependent cilia transition zone function , 2017, The Journal of cell biology.

[2]  Didier Samuel,et al.  SHIP2 Regulates Lumen Generation, Cell Division, and Ciliogenesis through the Control of Basolateral to Apical Lumen Localization of Aurora A and HEF 1. , 2016, Cell reports.

[3]  Sha X. Chang,et al.  Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway. , 2016, Cancer research.

[4]  O. Plotnikova,et al.  Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling. , 2016, Human molecular genetics.

[5]  P. Jackson,et al.  Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium , 2016, The Journal of cell biology.

[6]  C. Mitchell,et al.  Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases. , 2016, Biochemical Society transactions.

[7]  R. Carpenter,et al.  Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors , 2016, Cancers.

[8]  C. Kim,et al.  Ciliary Phosphoinositide Regulates Ciliary Protein Trafficking in Drosophila. , 2015, Cell reports.

[9]  J. Reiter,et al.  Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling , 2015, PLoS genetics.

[10]  V. Jensen,et al.  Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance , 2015, The EMBO journal.

[11]  S. Pedersen,et al.  PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism , 2015, Journal of Cell Science.

[12]  M. Scott,et al.  Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma , 2015, eLife.

[13]  S. Schurmans,et al.  Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. , 2015, Developmental cell.

[14]  M. Kassem,et al.  Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway , 2015, Biogerontology.

[15]  P. Timpson,et al.  The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. , 2015, Cancer cell.

[16]  S. Schiffmann,et al.  Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output. , 2015, Developmental cell.

[17]  Q. Jiang,et al.  GSK3β-Dzip1-Rab8 Cascade Regulates Ciliogenesis after Mitosis , 2015, PLoS biology.

[18]  K. Anderson,et al.  Lineage specificity of primary cilia in the mouse embryo , 2015, Nature Cell Biology.

[19]  O. Plotnikova,et al.  INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability , 2015, Journal of Cell Science.

[20]  Tingting Zhang,et al.  Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice. , 2014, Developmental biology.

[21]  L. Luo,et al.  Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling , 2014, Science.

[22]  M. Kool,et al.  The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma , 2014, Nature Medicine.

[23]  Steven J. M. Jones,et al.  Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. , 2014, Cancer cell.

[24]  Stephen L. Abrams,et al.  GSK-3 as potential target for therapeutic intervention in cancer , 2014, Oncotarget.

[25]  G. Merlo,et al.  PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function , 2014, Developmental cell.

[26]  Roland Eils,et al.  Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. , 2014, Cancer cell.

[27]  C. Rommel,et al.  PI3K and cancer: lessons, challenges and opportunities , 2014, Nature Reviews Drug Discovery.

[28]  D. Rowitch,et al.  Cerebellar cortical lamination and foliation require cyclin A2. , 2014, Developmental biology.

[29]  F. Peale,et al.  PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition. , 2013, Cancer research.

[30]  Sha X. Chang,et al.  Tonic Activation of Bax Primes Neural Progenitors for Rapid Apoptosis through a Mechanism Preserved in Medulloblastoma , 2013, The Journal of Neuroscience.

[31]  C. Sung,et al.  IGF-1 activates a cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression. , 2013, Developmental cell.

[32]  E. Anton,et al.  Arl13b-regulated cilia activities are essential for polarized radial glial scaffold formation , 2013, Nature Neuroscience.

[33]  Ryan M. Anderson,et al.  Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of Lowe , 2013, PloS one.

[34]  M. Scott,et al.  Kif3a is necessary for initiation and maintenance of medulloblastoma. , 2013, Carcinogenesis.

[35]  L. Rangell,et al.  The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling , 2013, Cell.

[36]  C. Mitchell,et al.  Inositol polyphosphate 5‐phosphatases; new players in the regulation of cilia and ciliopathies , 2012, FEBS letters.

[37]  Steven J. M. Jones,et al.  Subgroup-specific structural variation across 1,000 medulloblastoma genomes , 2012, Nature.

[38]  M. Giovannini,et al.  WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum , 2012, Development.

[39]  U. Schüller,et al.  Proper cerebellar development requires expression of β1‐integrin in Bergmann glia, but not in granule neurons , 2012, Glia.

[40]  P. Hawkins,et al.  PI3K signalling: the path to discovery and understanding , 2012, Nature Reviews Molecular Cell Biology.

[41]  W. Marshall,et al.  Stages of ciliogenesis and regulation of ciliary length. , 2012, Differentiation; research in biological diversity.

[42]  C. E. Larkins,et al.  Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins , 2011, Molecular biology of the cell.

[43]  M. Kool,et al.  Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans , 2011, Oncogene.

[44]  Axel Benner,et al.  FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[45]  U. Schüller,et al.  Severe Alterations of Cerebellar Cortical Development after Constitutive Activation of Wnt Signaling in Granule Neuron Precursors , 2011, Molecular and Cellular Biology.

[46]  J. Mesirov,et al.  Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[47]  Hendrik Witt,et al.  Medulloblastoma comprises four distinct molecular variants. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[48]  Helen Hoffmeister,et al.  Polycystin-2 takes different routes to the somatic and ciliary plasma membrane , 2011, The Journal of cell biology.

[49]  B. Wainwright,et al.  RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer , 2010, Neural Development.

[50]  D. Rowitch,et al.  Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma. , 2010, Cancer research.

[51]  T. MacDonald,et al.  Heterozygosity for Pten Promotes Tumorigenesis in a Mouse Model of Medulloblastoma , 2010, PloS one.

[52]  Hongkai Ji,et al.  Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis , 2010, Proceedings of the National Academy of Sciences.

[53]  T. Ideker,et al.  Functional genomic screen for modulators of ciliogenesis and cilium length , 2010, Nature.

[54]  Jeremy Stinson,et al.  Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. , 2009, The New England journal of medicine.

[55]  S. Schiffmann,et al.  INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse , 2009, Nature Genetics.

[56]  J. Reiter,et al.  Primary cilia can both mediate and suppress Hedgehog pathway–dependent tumorigenesis , 2009, Nature Medicine.

[57]  A. Álvarez-Buylla,et al.  Dual and opposing roles of primary cilia in medulloblastoma development , 2009, Nature Medicine.

[58]  Wade G. Regehr,et al.  Linking Genetically Defined Neurons to Behavior through a Broadly Applicable Silencing Allele , 2009, Neuron.

[59]  K. Liao,et al.  Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes , 2009, Journal of Cell Science.

[60]  G. Schiavo,et al.  Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P2 , 2009, The Biochemical journal.

[61]  P. Febbo,et al.  Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. , 2009, Cancer cell.

[62]  Robert Machold,et al.  Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. , 2008, Cancer cell.

[63]  Tao Sun,et al.  Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. , 2008, Cancer cell.

[64]  H. Moch,et al.  pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation , 2008, The EMBO journal.

[65]  J. García-Verdugo,et al.  Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. , 2008, Developmental biology.

[66]  J. Condeelis,et al.  Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. , 2008, The Biochemical journal.

[67]  O. Halevy,et al.  Sonic hedgehog promotes proliferation and differentiation of adult muscle cells: Involvement of MAPK/ERK and PI3K/Akt pathways. , 2007, Biochimica et biophysica acta.

[68]  J. Condeelis,et al.  The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration , 2007, Journal of Cell Science.

[69]  Erica A. Golemis,et al.  HEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium , 2007, Cell.

[70]  Claudio R. Thoma,et al.  pVHL and GSK3β are components of a primary cilium-maintenance signalling network , 2007, Nature Cell Biology.

[71]  Keith L Ligon,et al.  A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. , 2006, Cancer research.

[72]  J. Olson,et al.  N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. , 2006, Cancer research.

[73]  M. Layton,et al.  Phosphatidylinositol 3-Phosphate [PtdIns(3)P] Is Generated at thePlasma Membrane by an Inositol Polyphosphate 5-Phosphatase: Endogenous PtdIns(3)P Can Promote GLUT4 Translocation to the Plasma Membrane , 2006, Molecular and Cellular Biology.

[74]  C. Emerson,et al.  Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[75]  M. Pouliot,et al.  Rapid and simple comparison of messenger RNA levels using real-time PCR , 2006, Biological Procedures Online.

[76]  D. Rowitch,et al.  Smaller inner ear sensory epithelia in Neurog1 null mice are related to earlier hair cell cycle exit , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[77]  L. Hunyady,et al.  Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners , 2005, Journal of Cell Science.

[78]  Didier Y. R. Stainier,et al.  Vertebrate Smoothened functions at the primary cilium , 2005, Nature.

[79]  Gord Fishell,et al.  Math1 Is Expressed in Temporally Discrete Pools of Cerebellar Rhombic-Lip Neural Progenitors , 2005, Neuron.

[80]  D. Guertin,et al.  Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.

[81]  J. Manola,et al.  A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. , 2004, Nucleic acids research.

[82]  Jussi Taipale,et al.  Small molecule modulation of Smoothened activity , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[83]  James M. Olson,et al.  Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade , 2002, Science.

[84]  P. Majerus,et al.  Phosphoinositide-specific Inositol Polyphosphate 5-Phosphatase IV Inhibits Akt/Protein Kinase B Phosphorylation and Leads to Apoptotic Cell Death* , 2002, The Journal of Biological Chemistry.

[85]  X. Pesesse,et al.  Inositol Polyphosphate 5‐Phosphatases , 2002 .

[86]  M. Layton,et al.  Cloning and Characterization of a 72-kDa Inositol-polyphosphate 5-Phosphatase Localized to the Golgi Network* , 2000, The Journal of Biological Chemistry.

[87]  P. Majerus,et al.  The Isolation and Characterization of a cDNA Encoding Phospholipid-specific Inositol Polyphosphate 5-Phosphatase* , 2000, The Journal of Biological Chemistry.

[88]  D R Alessi,et al.  Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. , 1999, The Biochemical journal.

[89]  W. Sellers,et al.  Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[90]  F. McCormick,et al.  A frequent activated smoothened mutation in sporadic basal cell carcinomas , 1999, Oncogene.

[91]  P. Cohen,et al.  Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.

[92]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.