Modelling Aspects and Structural Properties of a Fed-Batch Bioprocess

This work deals with the modelling and the achievement of some structural properties for a nonlinear fed-batch prototype bioprocess: an aerobic microbial growth process coupled with an enzyme-catalyzed reaction. As a modelling procedure, Bond Graph approach is used. The model structural properties are analyzed, such as the partition in linear and nonlinear parts, the decoupling of kinetics, etc. Numerical simulations of the evolution of fed-batch bioprocess are provided by using both 20sim and MATLAB environments.

[1]  D. Dochain,et al.  On-Line Estimation and Adaptive Control of Bioreactors , 2013 .

[2]  Monica Roman,et al.  Pseudo Bond Graph modelling of some prototype bioprocesses , 2009 .

[3]  K. Schügerl,et al.  Progress in monitoring, modeling and control of bioprocesses during the last 20 years. , 2001, Journal of biotechnology.

[4]  Alan S. Perelson,et al.  Introduction to Bond Graphs and Their Applications , 1976, IEEE Transactions on Systems, Man, and Cybernetics.

[5]  B. Ould Bouamama,et al.  Modelling and Simulation in Thermal and Chemical Engineering: A Bond Graph Approach , 1999 .

[6]  Belkacem Ould Bouamama,et al.  Modelling and Simulation in Thermal and Chemical Engineering , 2000 .

[7]  Monica Roman,et al.  Structural properties and reduced order modeling of a class of bioprocesses , 2010, Proceedings of the 2010 International Conference on Modelling, Identification and Control.

[8]  Hassan K. Khalil,et al.  Singular perturbation methods in control : analysis and design , 1986 .

[9]  D. A. Linkens.  Bond graphs for an improved modelling environment in the life sciences , 1990 .

[10]  Monica Roman,et al.  Modeling and estimation strategies for a fed-batch prototype bioprocess , 2010, 2010 IEEE International Conference on Automation and Logistics.

[11]  Alan S. Perelson,et al.  System Dynamics: A Unified Approach , 1976, IEEE Transactions on Systems, Man, and Cybernetics.

[12]  Dorin Şendrescu,et al.  Pseudo Bond Graph modelling and on-line estimation of unknown kinetics for a wastewater biodegradation process , 2010, Simul. Model. Pract. Theory.

[13]  Bernd Hitzmann,et al.  Automatic control of bioprocesses. , 2013, Advances in biochemical engineering/biotechnology.