Photoacoustic mammography capable of simultaneously acquiring photoacoustic and ultrasound images

Abstract. We have constructed a prototype photoacoustic mammography system (PAM-02) capable of simultaneously acquiring photoacoustic (PA) and ultrasound (US) images. Each PA, US, and fused PA/US image can be acquired over a wide area of the breast using the scanning module of a US transducer, a PA detector, and optical prisms. The resolution of the PA images exhibits improvement from 2 to 1 mm compared to images acquired using our previous prototype. The maximum scan area of PAM-02 is 90 mm along the horizontal axis and 150 mm along the vertical axis. In a phantom experiment, the available depth was at least 45 mm. A representative example of the application of the PAM-02 prototype in clinical research at Kyoto University is presented and shows S-factor images, which are considered an approximation parameter related to hemoglobin saturation of tumor-related blood vessels. We confirmed the applicability of the system for anatomical and biological research.

[1]  F. M. van den Engh,et al.  Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics. , 2007, Optics express.

[2]  Qiang Wang,et al.  Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements. , 2007, Optics letters.

[3]  A. Oraevsky,et al.  Laser optoacoustic imaging system for detection of breast cancer. , 2009, Journal of biomedical optics.

[4]  M. Kataoka,et al.  Development of Photoacoustic Mammography for Detection of Breast Cancer , 2013 .

[5]  O. Oralkan,et al.  Integration of 2D CMUT arrays with front-end electronics for volumetric ultrasound imaging , 2008, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[6]  Hua-bei Jiang,et al.  Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection. , 2012, Medical physics.

[7]  S. Kanao,et al.  Photoacoustic mammography: initial clinical results , 2014, Breast Cancer.

[8]  Hirofumi Taki,et al.  High Range Resolution Ultrasonographic Vascular Imaging Using Frequency Domain Interferometry With the Capon Method , 2012, IEEE Transactions on Medical Imaging.

[9]  Wiendelt Steenbergen,et al.  Clinical Photoacoustic Breast Imaging: The Twente experience. , 2015, IEEE Pulse.

[10]  Walter J. Riker.  A Review of J , 2010 .

[12]  G. Bevilacqua,et al.  Angiogenesis and VEGF expression in pre‐invasive lesions of the human breast , 2004, The Journal of pathology.

[13]  M. Oda,et al.  Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy , 2014, Cancer science.

[14]  Hamid Dehghani,et al.  Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[15]  Antonio Cantoni,et al.  On an adaptive antenna array under directional constraint , 1985, IEEE Trans. Acoust. Speech Signal Process..

[16]  Lihong V. Wang,et al.  Reconstructions in limited-view thermoacoustic tomography. , 2004, Medical physics.

[17]  A. Harris,et al.  Targeting tumour hypoxia in breast cancer. , 2008, European journal of cancer.

[18]  F. M. van den Engh,et al.  Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology , 2015, Scientific Reports.

[19]  Minghua Xu,et al.  Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[20]  S. Arridge,et al.  Quantitative spectroscopic photoacoustic imaging: a review. , 2012, Journal of biomedical optics.

[21]  Makoto Yamakawa,et al.  Characterization of photoacoustic tomography system with dual illumination , 2011, BiOS.

[22]  Toru Takehisa,et al.  Nanocomposite Hydrogels: A Unique Organic–Inorganic Network Structure with Extraordinary Mechanical, Optical, and Swelling/De‐swelling Properties , 2002 .

[23]  K. Paulsen,et al.  Analysis of the microvasculature and tissue type ratios in normal vs. benign and malignant breast tissue. , 2004, Analytical and quantitative cytology and histology.

[24]  Lei Xi,et al.  High resolution functional photoacoustic tomography of breast cancer. , 2015, Medical physics.

[25]  H. Lynch,et al.  Psychologic Aspects of Cancer Genetic Testing: A Research Update for Clinicians , 1997 .

[26]  Lihong V. Wang,et al.  Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system. , 2012, Journal of biomedical optics.

[27]  Doreen Steed,et al.  Dedicated 3D photoacoustic breast imaging. , 2013, Medical physics.

[28]  Lihong V. Wang,et al.  Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer , 2015, Scientific Reports.

[29]  Keiji Shimizu,et al.  Near-infrared time-resolved spectroscopy system for tissue oxygenation monitor , 1999, Photonics West - Biomedical Optics.

[30]  Enrico Gratton,et al.  Assessing tumor contrast in radiographically dense breast tissue using Diffuse Optical Spectroscopic Imaging (DOSI) , 2013, Breast Cancer Research.

[31]  A. R. Selfridge,et al.  Approximate Material Properties in Isotropic Materials , 1985, IEEE Transactions on Sonics and Ultrasonics.

[32]  P. Beard.  Biomedical photoacoustic imaging , 2011, Interface Focus.

[33]  T. Powles,et al.  Reduction in angiogenesis after neoadjuvant chemoendocrine therapy in patients with operable breast carcinoma , 1999, Cancer.

[34]  L. Fajardo,et al.  Phase-contrast diffuse optical tomography for in vivo breast imaging: a two-step method. , 2009, Applied optics.

[35]  Alessandro Torricelli,et al.  Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography. , 2014, Biomedical optics express.