Recent advances in particle and droplet manipulation for lab-on-a-chip devices based on surface acoustic waves.

Manipulation of microscale particles and fluid liquid droplets is an important task for lab-on-a-chip devices for numerous biological researches and applications, such as cell detection and tissue engineering. Particle manipulation techniques based on surface acoustic waves (SAWs) appear effective for lab-on-a-chip devices because they are non-invasive, compatible with soft lithography micromachining, have high energy density, and work for nearly any type of microscale particles. Here we review the most recent research and development of the past two years in SAW based particle and liquid droplet manipulation for lab-on-a-chip devices including particle focusing and separation, particle alignment and patterning, particle directing, and liquid droplet delivery.

[1]  Fabio Beltram,et al.  Polydimethylsiloxane-LiNbO3 surface acoustic wave micropump devices for fluid control into microchannels. , 2008, Lab on a chip.

[2]  Michael W L Watson,et al.  Hybrid microfluidics: a digital-to-channel interface for in-line sample processing and chemical separations. , 2009, Lab on a chip.

[3]  H. Hertz,et al.  Wedge transducer design for two-dimensional ultrasonic manipulation in a microfluidic chip , 2008 .

[4]  Thomas Braschler,et al.  Continuous separation of cells by balanced dielectrophoretic forces at multiple frequencies. , 2008, Lab on a chip.

[5]  D A Weitz,et al.  Surface acoustic wave actuated cell sorting (SAWACS). , 2010, Lab on a chip.

[6]  K. Ness,et al.  Acoustic particle filter with adjustable effective pore size for automated sample preparation. , 2008, Analytical chemistry.

[7]  Daniel Ahmed,et al.  Focusing microparticles in a microfluidic channel with standing surface acoustic waves (SSAW). , 2008, Lab on a chip.

[8]  Aaron R Wheeler,et al.  Multilayer hybrid microfluidics: a digital-to-channel interface for sample processing and separations. , 2010, Analytical chemistry.

[9]  Joel Voldman,et al.  Separation of particles by pulsed dielectrophoresis. , 2009, Lab on a chip.

[10]  Daniel Ahmed,et al.  Acoustic tweezers: patterning cells and microparticles using standing surface acoustic waves (SSAW). , 2009, Lab on a chip.

[11]  Thomas Laurell,et al.  Decomplexing biofluids using microchip based acoustophoresis. , 2009, Lab on a chip.

[12]  E. Verpoorte,et al.  Charge-based particle separation in microfluidic devices using combined hydrodynamic and electrokinetic effects. , 2009, Lab on a chip.

[13]  Thomas Laurell,et al.  Acoustophoresis in wet-etched glass chips. , 2008, Analytical chemistry.

[14]  John E. Cunningham,et al.  Alignment of particles in microfluidic systems using standing surface acoustic waves , 2008 .

[15]  A. Abate,et al.  Surface acoustic wave (SAW) directed droplet flow in microfluidics for PDMS devices. , 2009, Lab on a chip.

[16]  Yong Qing Fu,et al.  Recent developments on ZnO films for acoustic wave based bio-sensing and microfluidic applications: a review , 2010 .

[17]  James Friend,et al.  Particle concentration and mixing in microdrops driven by focused surface acoustic waves , 2008 .

[18]  John E. Cunningham,et al.  Formation and manipulation of two-dimensional arrays of micron-scale particles in microfluidic systems by surface acoustic waves , 2009 .

[19]  P. Pouteau,et al.  Passive microfluidic devices for plasma extraction from whole human blood , 2008 .

[20]  Fabio Beltram,et al.  Acoustic-counterflow microfluidics by surface acoustic waves , 2008 .

[21]  Subramanian K. R. S. Sankaranarayanan,et al.  Enhancement of acoustic streaming induced flow on a focused surface acoustic wave device: Implications for biosensing and microfluidics , 2010 .

[22]  T. Huang,et al.  Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW). , 2009, Lab on a chip.

[23]  María-Isabel Rocha-Gaso,et al.  Surface Generated Acoustic Wave Biosensors for the Detection of Pathogens: A Review , 2009, Sensors.

[24]  D. Weitz,et al.  Fluorescence-activated droplet sorting (FADS): efficient microfluidic cell sorting based on enzymatic activity. , 2009, Lab on a chip.

[25]  Fabio Beltram,et al.  Surface-acoustic-wave counterflow micropumps for on-chip liquid motion control in two-dimensional microchannel arrays. , 2010, Lab on a chip.

[26]  R. Tompkins,et al.  Equilibrium separation and filtration of particles using differential inertial focusing. , 2008, Analytical chemistry.

[27]  J. Friend,et al.  Surface Acoustic Waves: A New Paradigm for Driving Ultrafast Biomicrofluidics , 2009 .

[28]  Thomas Laurell,et al.  Acoustic whole blood plasmapheresis chip for prostate specific antigen microarray diagnostics. , 2009, Analytical chemistry.

[29]  Fang Fang,et al.  A glass microfluidic chip for continuous blood cell sorting by a magnetic gradient without labeling , 2008, Analytical and bioanalytical chemistry.

[30]  Y. Fu,et al.  Moving-part-free microfluidic systems for lab-on-a-chip , 2009 .

[31]  Xingzhong Zhao,et al.  Ultrasonic particle trapping in microfluidic devices using soft lithography , 2008 .

[32]  Junjie Zhu,et al.  Particle focusing in microfluidic devices , 2010 .

[33]  Yong Qing Fu,et al.  Microfluidic pumps employing surface acoustic waves generated in ZnO thin films , 2009 .

[34]  A. Wixforth,et al.  Microfluidics for miniaturized laboratories on a chip. , 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

[35]  Leslie Y Yeo,et al.  Ultrafast microfluidics using surface acoustic waves. , 2009, Biomicrofluidics.

[36]  Vincent Aimez,et al.  Integrated active mixing and biosensing using surface acoustic waves (SAW) and surface plasmon resonance (SPR) on a common substrate. , 2010, Lab on a chip.

[37]  Fei Jingchen Research on the Transportation of Digital Micro Fluids Between Two Substrates Based on Surface Acoustic Wave , 2009 .

[38]  Julien Reboud,et al.  Tuneable surface acoustic waves for fluid and particle manipulations on disposable chips. , 2010, Lab on a chip.