Differences between plasma and CSF p-tau181 and p-tau231 in early Alzheimer s disease

Plasma phosphorylated tau species have been recently proposed as peripheral markers of Alzheimer s disease pathology. In this cross-sectional study incuding ninety-one subjects, plasma p-tau181 and p-tau231 levels were elevated in the early symptomatic stages of AD, with similar levels than those of CSF. Plasma p-tau231 and p-tau181 were strongly related to CSF tau and amyloid and exhibited a high accuracy, close to CSF p-tau231 and p-tau181, to identify AD already in the early stage of the disease. The findings might support the use as diagnostic and prognostic peripheral AD biomarkers in both research and clinical settings.