Modification of the Dissolution Behaviour of a Water‐insoluble Drug, Naftazone, for Zero‐order Release Matrix Preparation *

Abstract— The preparation of hydrophilic matrix tablets able to release naftazone, a water‐insoluble drug, into an aqueous medium at a constant rate (zero‐order dissolution) is described. Enhancement of dissolution rate of the drug was achieved using cross‐linked carmellose sodium, β‐cyclodextrin or hydroxypropyl‐β‐cyclodextrin. Hypromellose was used as a water‐gelling polymer. Tablets could be prepared that released naftazone at a constant rate over 16 h.