EPIPEN JR VERSUS EPIPEN IN YOUNG CHILDREN WEIGHING 15 TO 30 kg AT RISK FOR ANAPHYLAXIS

Simons FER, Gu X, Silver NA, Simons KJ. J Allergy Clin Immunol 2002;109:171–175 Epinephrine autoinjectors are widely prescribed for out-of-hospital treatment of children at risk for anaphylaxis. Prescribing physicians face the dilemma of choosing either the 0.15-mg EpiPen Jr or the 0.30-mg EpiPen when neither dose is deemed optimal. These investigators studied the rate and extent of epinephrine absorption after administration of either EpiPen Jr or EpiPen in children weighing 15 to 30 kg. Ten children were recruited from pediatric allergy practices with the following entry criteria: age, 4 to 8 years; weight. 15 to 30 kg; history of severe acute allergic reaction(s); and current EpiPen Jr or EpiPen carriage. …