In view of standardization Part 2: Management of challenges in the initial treatment of burn patients in Burn Centers in Germany, Austria and Switzerland.

INTRODUCTION Initial therapy of severe burns in specialized burn trauma centers is a challenging task faced by the treating multi-professional and interdisciplinary team. A lack of consistent operating procedures and varying structural conditions was recently demonstrated in preliminary data of our group. These results raised the question on how specific treatment measures in acute burn care are met in the absence of standardized guidelines. MATERIAL AND METHODS A specific questionnaire containing 57 multiple-choice questions was sent to all 22 major burn centers in Germany, Austria and Switzerland. The survey included standards of airway management and ventilation, fluid management and circulation, body temperature monitoring and management, topical burn wound treatment and a microbiological surveillance. Additionally, the distribution of standardized course systems was covered. RESULTS 17 out of 22 questionnaires (77%) were returned completed. Regarding volume resuscitation, results showed a similar approach in estimating initial fluid while discrepancies persisted in the use of colloidal fluid and human albumin. Elective tracheostomy and the need for bronchoscopy with suspected inhalation injury were the most controversial issues revealed by the survey. Topical treatment of burned body surface also followed different principles regarding the use of synthetic epidermal skin substitutes or enzymatic wound debridement. Less discrepancy was found in basic diagnostic measures, body temperature management, estimation of the extent of burns and microbiological surveillance. CONCLUSION While many burn-related issues are clearly not questionable and managed in a similar way in most participating facilities, we were able to show that the most contentious issues in burn trauma management involve initial volume resuscitation, management of inhalation trauma and topical burn wound treatment. Further research is required to address these topics and evaluate a potential superiority of a regime in order to increase the level of evidence.

[1]  Yaron Shoham,et al.  A novel rapid and selective enzymatic debridement agent for burn wound management: a multi-center RCT. , 2014, Burns : journal of the International Society for Burn Injuries.

[2]  D. Herndon,et al.  Randomized Clinical Study of Hydrofiber Dressing With Silver or Silver Sulfadiazine in the Management of Partial-Thickness Burns , 2006, Journal of burn care & research : official publication of the American Burn Association.

[4]  R. Cartotto,et al.  Does Bronchoscopic Evaluation of Inhalation Injury Severity Predict Outcome? , 2016, Journal of burn care & research : official publication of the American Burn Association.

[5]  A. Graziano,et al.  Introducing the advanced burn life support (ABLS) course in Italy. , 2014, Burns : journal of the International Society for Burn Injuries.

[6]  D. Kistler,et al.  Increased survival rates by topical treatment of burns with cerium nitrate. , 1990, European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.

[7]  E. de Vries,et al.  Factors that Predict the Need for Intubation in Patients with Smoke Inhalation Injury , 2006, Ear, nose, & throat journal.

[8]  J. Saffle,et al.  Burn patient characteristics and outcomes following resuscitation with albumin. , 2007, Burns : journal of the International Society for Burn Injuries.

[9]  S. Ruchholtz,et al.  Quality management in the early treatment of patients with multiple injuries. II. Quality improvement guidelines , 1997, Der Unfallchirurg.

[10]  J. Hunter Ventilator associated pneumonia , 2006, Postgraduate Medical Journal.

[11]  L. Berra,et al.  Ventilator-associated pneumonia or endotracheal tube-associated pneumonia or none of the above? Lessons learned from laboratory animal studies. , 2009, Anesthesiology.

[12]  S. Jayaraman,et al.  Advanced trauma life support training for hospital staff. , 2009, The Cochrane database of systematic reviews.

[13]  H. Cleland,et al.  Bioengineered skin substitutes for the management of burns: a systematic review. , 2007, Burns : journal of the International Society for Burn Injuries.

[14]  J. Hansbrough,et al.  Clinical experience with Biobrane biosynthetic dressing in the treatment of partial thickness burns. , 1984, Burns, including thermal injury.

[15]  A. Daigeler,et al.  Evaluation of angiogenesis, epithelialisation and microcirculation after application of polyhexanide, chitosan and sodium chloride in rodents , 2016, International Wound Journal.

[16]  J. Saffle,et al.  Colloid Administration Normalizes Resuscitation Ratio and Ameliorates “Fluid Creep” , 2010, Journal of burn care & research : official publication of the American Burn Association.

[17]  B. Bouillon,et al.  Sechs Jahre Advanced Trauma Life Support (ATLS) in Deutschland , 2010, Der Unfallchirurg.

[18]  N. Lioret,et al.  Using bronchoscopy and biopsy to diagnose early inhalation injury. Macroscopic and histologic findings. , 1995, Chest.

[19]  M. Mittlböck,et al.  The use of Suprathel(®) in deep dermal burns: first results of a prospective study. , 2012, Burns : journal of the International Society for Burn Injuries.

[20]  P. Vogt,et al.  Evaluation of infrastructure, equipment and training of 28 burn units/burn centers in Germany, Austria and Switzerland. , 2011, Burns : journal of the International Society for Burn Injuries.

[21]  Qiang Li,et al.  Application of flexible bronchoscopy in inhalation lung injury , 2013, Diagnostic Pathology.

[22]  M. O'mara,et al.  A prospective, randomized evaluation of intra-abdominal pressures with crystalloid and colloid resuscitation in burn patients. , 2005, The Journal of trauma.

[23]  J. Dirnberger,et al.  "Understanding burns": research project BurnCase 3D--overcome the limits of existing methods in burns documentation. , 2009, Burns : journal of the International Society for Burn Injuries.

[24]  B. Latenser,et al.  The Burn Edema Process: Current Concepts , 2006 .

[25]  C. G de Gracia,et al.  An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. , 2001 .

[26]  K. Chung,et al.  A primer on burn resuscitation , 2011, Journal of emergencies, trauma, and shock.

[27]  A. Kramer,et al.  Feasibility and Clinical Applicability of Polihexanide for Treatment of Second-Degree Burn Wounds , 2007, Skin Pharmacology and Physiology.

[28]  C. Baxter,et al.  PHYSIOLOGICAL RESPONSE TO CRYSTALLOID RESUSCITATION OF SEVERE BURNS , 1968, Annals of the New York Academy of Sciences.

[29]  H. Amani,et al.  Brother, Have You Got a Light? Assessing the Need for Intubation in Patients Sustaining Burn Injury Secondary to Home Oxygen Therapy , 2012, Journal of burn care & research : official publication of the American Burn Association.

[30]  W. Tuinebreijer,et al.  Effect of training in the Emergency Management of Severe Burns on the knowledge and performance of emergency care workers as measured by an online simulated burn incident. , 2011, Burns : journal of the International Society for Burn Injuries.

[31]  J. Minei,et al.  Abdominal complications after severe burns. , 2009, Journal of the American College of Surgeons.

[32]  Thomas Kremer,et al.  In view of standardization: comparison and analysis of initial management of severely burned patients in Germany, Austria and Switzerland. , 2015, Burns : journal of the International Society for Burn Injuries.

[33]  H. Planck,et al.  Suprathel-an innovative, resorbable skin substitute for the treatment of burn victims. , 2007, Burns : journal of the International Society for Burn Injuries.

[34]  A. Cooper,et al.  How well does the Parkland formula estimate actual fluid resuscitation volumes? , 2002, The Journal of burn care & rehabilitation.

[35]  V. Wedler,et al.  Care of burns victims in Europe. , 1999, Burns : journal of the International Society for Burn Injuries.

[36]  D. Saitoh,et al.  Experiences in organizing Advanced Burn Life Support (ABLS) provider courses in Japan. , 2010, Burns.

[37]  O. Lotter,et al.  A clinical evaluation of Biobrane(®) and Suprathel(®) in acute burns and reconstructive surgery. , 2011, Burns : journal of the International Society for Burn Injuries.

[38]  S. Ruchholtz,et al.  [Quality management in early clinical polytrauma management. II. Optimizing therapy by treatment guidelines]. , 1997, Der Unfallchirurg.

[39]  Henian Chen,et al.  The Evaluation of Physical Exam Findings in Patients Assessed for Suspected Burn Inhalation Injury , 2015, Journal of burn care & research : official publication of the American Burn Association.

[40]  C G de Gracia,et al.  An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. , 2001, Burns : journal of the International Society for Burn Injuries.

[41]  N. Harunari,et al.  Resuscitation fluid volume and abdominal compartment syndrome in patients with major burns. , 2006, Burns : journal of the International Society for Burn Injuries.

[42]  P. Dziewulski,et al.  Tracheostomy in burns patients revisited. , 2009, Burns : journal of the International Society for Burn Injuries.

[43]  C. Serrano,et al.  A system for 3D representation of burns and calculation of burnt skin area. , 2011, Burns : journal of the International Society for Burn Injuries.

[44]  A. Singer,et al.  Management of local burn wounds in the ED. , 2007, The American journal of emergency medicine.

[45]  A. Ibrahim,et al.  Acute burn resuscitation and fluid creep: it is time for colloid rehabilitation. , 2012, Annals of burns and fire disasters.

[46]  D. Heimbach,et al.  An Analysis of the Long-Distance Transport of Burn Patients to a Regional Burn Center , 2007, Journal of burn care & research : official publication of the American Burn Association.

[47]  B. Latenser Burn resuscitation: The results of the ISBI/ABA survey , 2012 .

[48]  Randy D Kearns,et al.  Advanced Burn Life Support for Day-to-Day Burn Injury Management and Disaster Preparedness: Stakeholder Experiences and Student Perceptions Following 56 Advanced Burn Life Support Courses , 2015, Journal of burn care & research : official publication of the American Burn Association.

[49]  D. Greenhalgh,et al.  Albumin in Burn Shock Resuscitation: A Meta-Analysis of Controlled Clinical Studies , 2016, Journal of burn care & research : official publication of the American Burn Association.

[50]  S. Pape,et al.  Evolution of the Emergency Management of Severe Burns (EMSB) course in the UK. , 1999, Burns : journal of the International Society for Burn Injuries.

[51]  R M Kimble,et al.  3D photography is as accurate as digital planimetry tracing in determining burn wound area. , 2015, Burns : journal of the International Society for Burn Injuries.

[52]  Ae-Ri Cho Lee,et al.  Reversal of silver sulfadiazine-impaired wound healing by epidermal growth factor. , 2005, Biomaterials.

[53]  N. Pallua,et al.  Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns. , 2011, Burns : journal of the International Society for Burn Injuries.

[54]  C. Heitmann,et al.  Topical application of cerium nitrate prevents burn edema after burn plasma transfer. , 2009, Microvascular research.

[55]  J. Still,et al.  Experience with Pneumonia in Acutely Burned Patients Requiring Ventilator Support , 2000, The American surgeon.

[56]  Jameel Ali,et al.  Attrition of advanced trauma life support (ATLS) skills among ATLS instructors and providers in Mexico. , 2002, Journal of the American College of Surgeons.

[57]  A. Andriessen,et al.  Fibreoptic bronchoscopy in routine clinical practice in confirming the diagnosis and treatment of inhalation burns. , 2007, Burns : journal of the International Society for Burn Injuries.

[58]  P. Gosling,et al.  Microalbuminuria: a marker of endothelial dysfunction in thermal injury. , 2006, Burns : journal of the International Society for Burn Injuries.

[59]  W. Chun,et al.  Inhalation injury in burn patients: establishing the link between diagnosis and prognosis. , 2014, Burns : journal of the International Society for Burn Injuries.

[60]  J. Dirnberger,et al.  The determination of total burn surface area: How much difference? , 2013, Burns : journal of the International Society for Burn Injuries.

[61]  M. Eikermann,et al.  The treatment of patients with severe and multiple traumatic injuries. , 2012, Deutsches Arzteblatt international.

[62]  L. Cancio,et al.  Simple derivation of the initial fluid rate for the resuscitation of severely burned adult combat casualties: in silico validation of the rule of 10. , 2010, The Journal of trauma.

[63]  H. Rode,et al.  The Emergency Management of Severe Burns course in South Africa. , 2013, South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie.

[64]  M. Ives,et al.  Percutaneous dilational and surgical tracheostomy in burn patients: incidence of complications and dysphagia. , 2014, Burns : journal of the International Society for Burn Injuries.

[65]  Jeffrey S. Young,et al.  Burn-Center Quality Improvement: Are Burn Outcomes Dependent on Admitting Facilities and is There a Volume-Outcome “Sweet-Spot”? , 2012, The American surgeon.

[66]  L. Cancio,et al.  Evolution of Burn Resuscitation in Operation Iraqi Freedom , 2006, Journal of burn care & research : official publication of the American Burn Association.

[67]  M. Haberal,et al.  Current status of burn care facilities: a nationwide survey. , 2005, Burns : journal of the International Society for Burn Injuries.

[68]  D. Mozingo Microbial Contamination in Burn Patients Undergoing Urgent Intubation as Part of Their Early Airway Management , 2009 .

[69]  F. Abu-Zidan,et al.  Educational and Clinical Impact of Advanced Trauma Life Support (ATLS) Courses: A Systematic Review , 2014, World Journal of Surgery.

[70]  A. Cochran Inhalation Injury and Endotracheal Intubation , 2009, Journal of burn care & research : official publication of the American Burn Association.

[71]  A. Gravvanis,et al.  Percutaneous versus Conventional Tracheostomy in Burned Patients with Inhalation Injury , 2005, World Journal of Surgery.