ELECTROLYTE CHANGES IN HUMAN STRIATED MUSCLE IN ACIDOSIS AND ALKALOSIS.

In recent years many studies have been reported on the monovalent cation composition of the intracellular space during experimentally produced potassium depletion. The most consistent changes have been found in striated muscle and, in general, have shown that decreased concentrations of intracellular potassium are associated with an increase in intracellular sodium. Such changes have been reported in the rat (1), the cat (2), and the dog (2) following low potassium diets. The administration of desoxycorticosterone acetate in large doses has produced similar changes in the same animals (24). Recently Darrow has reported comparable findings in association with alkalosis, as determined by muscle analyses in rats (5) and indirectly by balance studies in man (6). Inasmuch as direct studies of human tissues during states of potassium depletion have not been reported, the present studies were undertaken in an attempt to define the composition of the intracellular electrolytes of striated muscle obtained by biopsy from patients with metabolic alkalosis and acidosis.

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