Two genetic hits (more or less) to cancer

[1]  Allan Balmain,et al.  Cancer genetics: from Boveri and Mendel to microarrays , 2001, Nature Reviews Cancer.

[2]  C. Sawyers,et al.  Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. , 2001, The New England journal of medicine.

[3]  S. Goodman,et al.  Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis. , 2001, Cancer research.

[4]  D. Rimm,et al.  Validation of Tissue Microarray Technology in Breast Carcinoma , 2000, Laboratory Investigation.

[5]  N. Petrelli,et al.  The onset and extent of genomic instability in sporadic colorectal tumor progression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Hudson,et al.  In vivo gene expression profile analysis of human breast cancer progression. , 1999, Cancer research.

[7]  Ash A. Alizadeh,et al.  Genome-wide analysis of DNA copy-number changes using cDNA microarrays , 1999, Nature Genetics.

[8]  A. Berno,et al.  High-throughput polymorphism screening and genotyping with high-density oligonucleotide arrays. , 1999, Genetic analysis : biomolecular engineering.

[9]  K. Kinzler,et al.  Genetic instabilities in human cancers , 1998, Nature.

[10]  L. Liotta,et al.  Laser-capture microdissection: opening the microscopic frontier to molecular analysis. , 1998, Trends in genetics : TIG.

[11]  J. Kononen,et al.  Tissue microarrays for high-throughput molecular profiling of tumor specimens , 1998, Nature Medicine.

[12]  B. Calabretta,et al.  Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway , 1997, The EMBO journal.

[13]  Jürg Zimmermann,et al.  Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells , 1996, Nature Medicine.

[14]  G. Woude,et al.  Abnormal Centrosome Amplification in the Absence of p53 , 1996, Science.

[15]  K. Kinzler,et al.  Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. , 1995, Science.

[16]  M. Meuth,et al.  Mutator phenotypes in human colorectal carcinoma cell lines. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Y. Nakamura,et al.  Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP). , 1992, Human molecular genetics.

[18]  M. Seki,et al.  Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. , 1992, Cancer research.

[19]  K. Kinzler,et al.  Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. , 1991, Science.

[20]  A. Kimchi,et al.  Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 , 1991, Nature.

[21]  L. Loeb,et al.  Mutator phenotype may be required for multistage carcinogenesis. , 1991, Cancer research.

[22]  L. Strong,et al.  Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. , 1990, Science.

[23]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[24]  A. Levine,et al.  The p53 proto-oncogene can act as a suppressor of transformation , 1989, Cell.

[25]  Stephen H. Friend,et al.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.

[26]  N. Heisterkamp,et al.  Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. , 1985, The New England journal of medicine.

[27]  E. Canaani,et al.  Fused transcript of abl and bcr genes in chronic myelogenous leukaemia , 1985, Nature.

[28]  O. Witte,et al.  Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[29]  T. P. Dryja,et al.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma , 1983, Nature.

[30]  C. Croce,et al.  Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[31]  P. Leder,et al.  Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[32]  S H Moolgavkar,et al.  Mutation and cancer: a model for human carcinogenesis. , 1981, Journal of the National Cancer Institute.

[33]  R. Weinberg,et al.  Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[34]  S. Moolgavkar,et al.  Two-event models for carcinogenesis: incidence curves for childhood and adult tumors☆ , 1979 .

[35]  A. Levine,et al.  Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells , 1979, Cell.

[36]  D. Lane,et al.  T antigen is bound to a host protein in SY40-transformed cells , 1979, Nature.

[37]  A. Knudson,et al.  Model for the incidence of embryonal cancers: application to retinoblastoma. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[38]  A. Knudson Retinoblastoma: a prototypic hereditary neoplasm. , 1978, Seminars in oncology.

[39]  W. W. Nichols,et al.  Chromosomal deletion and retinoblastoma. , 1976, The New England journal of medicine.

[40]  H. Varmus,et al.  DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA , 1976, Nature.

[41]  D. Comings A general theory of carcinogenesis. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Rowley A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining , 1973, Nature.

[43]  B. Ames,et al.  Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens , 1972, Science.

[44]  A. Knudson Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[45]  D. Ashley Colonic cancer arising in polyposis coli. , 1969, Journal of medical genetics.

[46]  J. Fraumeni,et al.  Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? , 1969, Annals of internal medicine.

[47]  D. J. Ashley,et al.  The two "hit" and multiple "hit" theories of carcinogenesis. , 1969, British Journal of Cancer.

[48]  J. Cleaver Defective Repair Replication of DNA in Xeroderma Pigmentosum , 1968, Nature.

[49]  P. Armitage,et al.  A Two-stage Theory of Carcinogenesis in Relation to the Age Distribution of Human Cancer , 1957, British Journal of Cancer.

[50]  Nordling Co A New Theory on the Cancer-inducing Mechanism , 1953 .

[51]  C. Nordling A New Theory on the Cancer-inducing Mechanism , 1953, British Journal of Cancer.

[52]  P. Shubik,et al.  A New, Quantitative, Approach to the Study of the Stages of Chemical Carcinogenesis in the Mouse's Skin , 1947, British Journal of Cancer.

[53]  H J Muller,et al.  ARTIFICIAL TRANSMUTATION OF THE GENE. , 1927, Science.

[54]  Ian Tomlinson,et al.  Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog , 1999, Nature medicine.

[55]  U. Francke,et al.  Sporadic bilateral retinoblastoma and 13q- chromosomal deletion. , 1976, Medical and pediatric oncology.

[56]  A. Knudson Mutation and Human Cancer , 1973 .

[57]  P. Nowell,et al.  A minute chromosome in human chronic granulocytic leukemia , 1960 .

[58]  H. Muller Radiation damage to the genetic material. , 1950, American scientist.

[59]  Theodor Boveri Zur Frage der Entstehung maligner Tumoren , 1914 .