Anisotropic Ti-6Al-4V gyroid scaffolds manufactured by electron beam melting (EBM) for bone implant applications

Abstract Ti-6Al-4V gyroid scaffolds with high porosities in the range of 82–85% and three different unit cell sizes 2, 2.5 and 3 mm were manufactured by electron beam melting (EBM) for bone implant applications. The microstructure, mechanical properties and failure mode of the scaffolds with different sample orientations were evaluated. The as-built struts showed orthogonally orientated martensite α′ needles in columnar grains along the building direction with an average hardness of 3.89 GPa and the elastic modulus and yield strength of scaffolds ranged from 637 to 1084 MPa and from 13.1 to 19.2 MPa, respectively. The elastic modulus and yield strength along the build direction and perpendicular to building direction varied by ~ 70% and 49%, respectively, depending on the amount of structural anisotropy and unit cell size. The ratio of elastic modulus anisotropy in orthogonal directions was comparable to those of trabecular bone and could be in favor of bone implant applications. Furthermore, as-built scaffolds showed a mixed mode of ductile and brittle behavior under compression, and the dominant failure mode was by forming orthogonal crush bonds at the peak loads with an angle of ~ 45° with compression axis.

[1]  Carolin Körner,et al.  Compression-compression fatigue of selective electron beam melted cellular titanium (Ti-6Al-4V). , 2011, Journal of biomedical materials research. Part B, Applied biomaterials.

[2]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[3]  Wei Xu,et al.  Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review. , 2016, Biomaterials.

[4]  Chee Kai Chua,et al.  An experimental and simulation study on build thickness dependent microstructure for electron beam melted Ti–6Al–4V , 2015 .

[5]  A A Zadpoor,et al.  Failure mechanisms of additively manufactured porous biomaterials: Effects of porosity and type of unit cell. , 2015, Journal of the mechanical behavior of biomedical materials.

[6]  Wei Wang,et al.  Compressive and fatigue behavior of beta-type titanium porous structures fabricated by electron beam melting , 2017 .

[7]  Chee Kai Chua,et al.  Graded microstructure and mechanical properties of additive manufactured Ti–6Al–4V via electron beam melting , 2015 .

[8]  D. Yoo Porous scaffold design using the distance field and triply periodic minimal surface models. , 2011, Biomaterials.

[9]  Mamoru Mabuchi,et al.  Processing of biocompatible porous Ti and Mg , 2001 .

[10]  W. Yeong,et al.  Selective laser melting of stainless steel 316L with low porosity and high build rates , 2016 .

[11]  Lewis Mullen,et al.  Selective Laser Melting: a regular unit cell approach for the manufacture of porous, titanium, bone in-growth constructs, suitable for orthopedic applications. , 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

[12]  Ryan B. Wicker,et al.  Characterization of titanium aluminide alloy components fabricated by additive manufacturing using electron beam melting , 2010 .

[13]  Dong-Jin Yoo,et al.  Computer-aided porous scaffold design for tissue engineering using triply periodic minimal surfaces , 2011 .

[14]  P Augat,et al.  Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations. , 1998, Medical engineering & physics.

[15]  A. Yánez,et al.  Compressive behaviour of gyroid lattice structures for human cancellous bone implant applications. , 2016, Materials science & engineering. C, Materials for biological applications.

[16]  S. M. Ahmadi,et al.  Additively Manufactured Open-Cell Porous Biomaterials Made from Six Different Space-Filling Unit Cells: The Mechanical and Morphological Properties , 2015, Materials.

[17]  M. Ashby,et al.  Cellular solids: Structure & properties , 1988 .

[18]  M. Mabuchi,et al.  Processing and mechanical properties of autogenous titanium implant materials , 2002, Journal of materials science. Materials in medicine.

[19]  Shu Beng Tor,et al.  Spatial and geometrical-based characterization of microstructure and microhardness for an electron beam melted Ti–6Al–4V component , 2016 .

[20]  C. Wen,et al.  Metal scaffolds processed by electron beam melting for biomedical applications , 2017 .

[21]  Klaus Mecke,et al.  Minimal surface scaffold designs for tissue engineering. , 2011, Biomaterials.

[22]  J Kadkhodapour,et al.  Effect of solid distribution on elastic properties of open-cell cellular solids using numerical and experimental methods. , 2014, Journal of the mechanical behavior of biomedical materials.

[23]  W. Yeong,et al.  Metallic powder-bed based 3D printing of cellular scaffolds for orthopaedic implants: A state-of-the-art review on manufacturing, topological design, mechanical properties and biocompatibility. , 2017, Materials science & engineering. C, Materials for biological applications.

[24]  Lorna J. Gibson,et al.  Modelling the mechanical behavior of cellular materials , 1989 .

[25]  Kathy K. Wang The use of titanium for medical applications in the USA , 1996 .

[26]  A. A. Zadpoor,et al.  Mechanical properties of open-cell metallic biomaterials manufactured using additive manufacturing , 2013 .

[27]  Wenbo Jiang,et al.  In vitro and in vivo study of additive manufactured porous Ti6Al4V scaffolds for repairing bone defects , 2016, Scientific Reports.

[28]  Mitsuo Niinomi,et al.  Recent metallic materials for biomedical applications , 2002 .

[29]  A. Nemati,et al.  Porous Ti6Al4V scaffolds for dental implants: Microstructure, mechanical, and corrosion behavior , 2016 .

[30]  L. Fedrizzi,et al.  Preparation and Characterization of Newly Developed Trabecular Structures in Titanium Alloy to Optimize Osteointegration , 2014 .

[31]  Lars-Erik Rännar,et al.  Fabrication of multiple-layered gradient cellular metal scaffold via electron beam melting for segmental bone reconstruction , 2017 .

[32]  S. M. Ahmadi,et al.  Mechanical behavior of regular open-cell porous biomaterials made of diamond lattice unit cells. , 2014, Journal of the mechanical behavior of biomedical materials.

[33]  Alexander A. Pasko,et al.  Procedural function-based modelling of volumetric microstructures , 2011, Graph. Model..

[34]  Jan Feijen,et al.  A poly(D,L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography. , 2009, Biomaterials.

[35]  Yong-qiang Yang,et al.  Mechanical Properties of Ti-6Al-4V Octahedral Porous Material Unit Formed by Selective Laser Melting , 2012 .

[36]  P H Krebsbach,et al.  Engineering craniofacial scaffolds. , 2005, Orthodontics & craniofacial research.

[37]  C. Bowen,et al.  Development of Modelling Methods for Materials to be Used as Bone Substitutes , 2007 .

[38]  Harri Korhonen,et al.  Preparation of poly(ε-caprolactone)-based tissue engineering scaffolds by stereolithography. , 2011, Acta biomaterialia.

[39]  Liang Hao,et al.  Ti-6Al-4V triply periodic minimal surface structures for bone implants fabricated via selective laser melting. , 2015, Journal of the mechanical behavior of biomedical materials.

[40]  S M Giannitelli,et al.  Current trends in the design of scaffolds for computer-aided tissue engineering. , 2014, Acta biomaterialia.

[41]  Richard A. Robb,et al.  Schwarz meets Schwann: Design and fabrication of biomorphic and durataxic tissue engineering scaffolds , 2006, Medical Image Anal..

[42]  L. Murr,et al.  Compression deformation behavior of Ti-6Al-4V alloy with cellular structures fabricated by electron beam melting. , 2012, Journal of the mechanical behavior of biomedical materials.

[43]  H. J. Rack,et al.  Phase transformations during cooling in α+β titanium alloys , 1998 .

[44]  Ahmed Hussein,et al.  Evaluations of cellular lattice structures manufactured using selective laser melting , 2012 .

[45]  D. Pasini,et al.  High-strength porous biomaterials for bone replacement: A strategy to assess the interplay between cell morphology, mechanical properties, bone ingrowth and manufacturing constraints. , 2016, Acta biomaterialia.

[46]  Yang Hao,et al.  Compression fatigue behavior of Ti-6Al-4V mesh arrays fabricated by electron beam melting , 2012 .

[47]  Robert F. Singer,et al.  Selective Electron Beam Melting of Cellular Titanium: Mechanical Properties , 2008 .

[48]  S. M. Ahmadi,et al.  Effects of bio-functionalizing surface treatments on the mechanical behavior of open porous titanium biomaterials. , 2014, Journal of the mechanical behavior of biomedical materials.

[49]  Cuie Wen,et al.  Biomimetic Porous Titanium Scaffolds for Orthopedic and Dental Applications , 2010 .

[50]  Chee Kai Chua,et al.  Revealing martensitic transformation and α/β interface evolution in electron beam melting three-dimensional-printed Ti-6Al-4V , 2016, Scientific Reports.

[51]  L. Murr,et al.  Influence of cell shape on mechanical properties of Ti-6Al-4V meshes fabricated by electron beam melting method. , 2014, Acta biomaterialia.

[52]  Ryan B. Wicker,et al.  Microstructures and mechanical properties of electron beam-rapid manufactured Ti–6Al–4V biomedical prototypes compared to wrought Ti–6Al–4V , 2009 .

[53]  J. Jansen,et al.  Implant Surface Roughness and Bone Healing: a Systematic Review , 2006, Journal of dental research.

[54]  Hamid Nayeb-Hashemi,et al.  Mechanical properties of open-cell rhombic dodecahedron cellular structures , 2012 .

[55]  Iain Todd,et al.  XCT analysis of the influence of melt strategies on defect population in Ti?6Al?4V components manufactured by Selective Electron Beam Melting , 2015 .

[56]  S. S. Al-Bermani,et al.  The Origin of Microstructural Diversity, Texture, and Mechanical Properties in Electron Beam Melted Ti-6Al-4V , 2010 .

[57]  André Luiz Jardini,et al.  Microstructure and mechanical behavior of porous Ti-6Al-4V parts obtained by selective laser melting. , 2013, Journal of the mechanical behavior of biomedical materials.

[58]  Clemens A van Blitterswijk,et al.  Bone ingrowth in porous titanium implants produced by 3D fiber deposition. , 2007, Biomaterials.

[59]  Shivakumar Raman,et al.  Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM). , 2010, Journal of the mechanical behavior of biomedical materials.

[60]  Clemens A van Blitterswijk,et al.  Effects of the architecture of tissue engineering scaffolds on cell seeding and culturing. , 2010, Acta biomaterialia.

[61]  E. Brunner,et al.  Growth behavior, matrix production, and gene expression of human osteoblasts in defined cylindrical titanium channels. , 2004, Journal of biomedical materials research. Part A.

[62]  Ola L. A. Harrysson,et al.  Flexural properties of Ti6Al4V rhombic dodecahedron open cellular structures fabricated with electron beam melting , 2014 .

[63]  Katia Bertoldi,et al.  Mathematically defined tissue engineering scaffold architectures prepared by stereolithography. , 2010, Biomaterials.

[64]  Hui Wang,et al.  Microstructure, defects and mechanical behavior of beta-type titanium porous structures manufactured by electron beam melting and selective laser melting , 2016 .

[65]  I. Gibson,et al.  Effects of scaffold architecture on cranial bone healing. , 2013, International journal of oral and maxillofacial surgery.

[66]  P. Bártolo,et al.  Structural Shear Stress Evaluation of Triple Periodic Minimal Surfaces , 2015 .

[67]  Martin Leary,et al.  Deformation and failure behaviour of Ti-6Al-4V lattice structures manufactured by selective laser melting (SLM) , 2015 .

[68]  L. Murr,et al.  Comparison of the microstructures and mechanical properties of Ti–6Al–4V fabricated by selective laser melting and electron beam melting , 2016 .

[69]  Mamoru Mabuchi,et al.  Novel titanium foam for bone tissue engineering , 2002 .

[70]  J. Tuukkanen,et al.  Effect of porosity on the osteointegration and bone ingrowth of a weight-bearing nickel-titanium bone graft substitute. , 2003, Biomaterials.

[71]  C. Wen,et al.  Porous shape memory alloy scaffolds for biomedical applications: a review , 2010 .

[72]  Dong-Jin Yoo,et al.  An advanced multi-morphology porous scaffold design method using volumetric distance field and beta growth function , 2015 .