The Relationship Between Laboratory and Ambulatory Cardiovascular Activity: Current Evidence and Future Directions1–3

This review examines studies which have investigated the relationships between laboratory and field cardiovascular activity. These studies explore associations between cardiovascular data collected during typical laboratory stress-testing paradigms and data collected via ambulatory monitoring while subjects are engaged in their usual activities outside the experimental laboratory. Despite the widely ranging methodologies and analytical techniques, it can be concluded that there is presently moderate evidence for laboratory-field generalization of cardiovascular activity, although the evidence varies in strength for different types of laboratory-field associations. Suggested future directions include the incorporation of several promising analytical techniques, consideration of physical activity and posture, the employment of ambulatory hemodynamic data when the advent of appropriate hardware permits, and the assessment of cardiovascular activity during both specific and non-specific stressors in a single paradigm.