Successful treatment of childhood‐onset Cushing's disease is associated with persistent reduction in growth hormone secretion

objective  Although Cushing's disease (CD) rarely occurs in childhood, affected children commonly fail to achieve predicted adult height. Hypercortisolaemia results in reduced GH secretion and GH‐deficiency may persist or demonstrate delayed recovery after successful treatment of CD in adults. Whether recovery of spontaneous GH secretion occurs following treatment of childhood CD has yet to be established.

[1]  R. Voutilainen,et al.  Growth in Cushing syndrome , 1985, European Journal of Pediatrics.

[2]  A. Grossman,et al.  Linear growth and final height after treatment for Cushing's disease in childhood. , 2000, The Journal of clinical endocrinology and metabolism.

[3]  N. Skakkebaek,et al.  Continuation of growth hormone (GH) replacement in GH-deficient patients during transition from childhood to adulthood: a two-year placebo-controlled study. , 2000, The Journal of clinical endocrinology and metabolism.

[4]  B. Bengtsson,et al.  Discontinuation of Growth Hormone (GH) Treatment: Metabolic Effects in GH-Deficient and GH-Sufficient Adolescent Patients Compared with Control Subjects* , 1999 .

[5]  Plowman.  Pituitary adenoma radiotherapy–when, who and how? , 1999, Clinical endocrinology.

[6]  Shalet,et al.  Growth hormone status following treatment for Cushing's syndrome , 1999, Clinical endocrinology.

[7]  B. Brennan,et al.  The diagnosis of growth hormone deficiency in children and adults. , 1998, Endocrine reviews.

[8]  E. Ghigo,et al.  Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency. , 1998, The Journal of clinical endocrinology and metabolism.

[9]  S. Gitelman,et al.  Long-term outcome in children and adolescents after transsphenoidal surgery for Cushing's disease. , 1997, The Journal of clinical endocrinology and metabolism.

[10]  V. Tillmann,et al.  Biochemical tests in the diagnosis of childhood growth hormone deficiency. , 1997, The Journal of clinical endocrinology and metabolism.

[11]  D. Allen.  Growth suppression by glucocorticoid therapy. , 1996, Endocrinology and metabolism clinics of North America.

[12]  M. Korbonits,et al.  Diagnosis of growth hormone deficiency in adults. , 1996, Hormone research.

[13]  A. Grossman,et al.  Investigation, management and therapeutic outcome in 12 cases of childhood and adolescent Cushing's syndrome , 1995, Clinical endocrinology.

[14]  G. Besser,et al.  The Bart's endocrine protocols , 1995 .

[15]  G. Chrousos,et al.  Final stature in patients with endogenous Cushing's syndrome. , 1994, The Journal of clinical endocrinology and metabolism.

[16]  J. Doppman,et al.  Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy. , 1994, The New England journal of medicine.

[17]  M. Leinung,et al.  Cushing's disease in children. , 1994, Endocrinology and metabolism clinics of North America.

[18]  G. Chrousos,et al.  Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure. , 1994, The Journal of clinical endocrinology and metabolism.

[19]  P. Sönksen,et al.  The growth hormone deficiency syndrome in adults , 1992, Clinical endocrinology.

[20]  M. Littley,et al.  Hypopituitarism following external radiotherapy for pituitary tumours in adults. , 1989, The Quarterly journal of medicine.

[21]  L. Phillips,et al.  Glucocorticoid effects on somatomedins and somatomedin inhibitors. , 1985, The Journal of clinical endocrinology and metabolism.

[22]  D. Orth,et al.  Results of treating childhood Cushing's disease with pituitary irradiation. , 1977, The New England journal of medicine.

[23]  A. B. Hayles,et al.  Cushing's disease in children. Findings in 13 cases. , 1972, Mayo Clinic proceedings.

[24]  F. S. French,et al.  Growth retardation in Cushing's syndrome. , 1972, American journal of diseases of children.