Reverse Pharmacognosy: A Tool to Accelerate the Discovery of New Bioactive Food Ingredients

[1]  J. Medina-Franco,et al.  Systematic mining of generally recognized as safe (GRAS) flavor chemicals for bioactive compounds. , 2013, Journal of agricultural and food chemistry.

[2]  Tom L. Blundell,et al.  CREDO: a structural interactomics database for drug discovery , 2013, Database J. Biol. Databases Curation.

[3]  Hyun Seob Cho,et al.  Inhibition of Pseudomonas aeruginosa and Escherichia coli O157:H7 biofilm formation by plant metabolite ε-viniferin. , 2013, Journal of agricultural and food chemistry.

[4]  Xiaofeng Liu,et al.  ChemMapper: a versatile web server for exploring pharmacology and chemical structure association based on molecular 3D similarity method , 2013, Bioinform..

[5]  Sereina Riniker,et al.  Open-source platform to benchmark fingerprints for ligand-based virtual screening , 2013, Journal of Cheminformatics.

[6]  P. Rochon,et al.  A Systematic Review and Methodological Evaluation of Published Cost-Effectiveness Analyses of Aromatase Inhibitors versus Tamoxifen in Early Stage Breast Cancer , 2013, PloS one.

[7]  B. Johansen,et al.  The ω3‐polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A2 and suppress PGE2 formation in mesangial cells , 2012, British journal of pharmacology.

[8]  José L. Medina-Franco,et al.  Chemoinformatic Analysis of GRAS (Generally Recognized as Safe) Flavor Chemicals and Natural Products , 2012, PloS one.

[9]  Wei-Tien Chang,et al.  Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages. , 2012, Food chemistry.

[10]  C. Ross,et al.  trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease* , 2012, The Journal of Biological Chemistry.

[11]  Hao Zheng,et al.  (Z)2‐(5‐(4‐methoxybenzylidene)‐2, 4‐dioxothiazolidin‐3‐yl) acetic acid protects rats from CCl4‐induced liver injury , 2012, Journal of gastroenterology and hepatology.

[12]  Y. Takasaki,et al.  Inhibitory effects of ZSTK474, a phosphatidylinositol 3-kinase inhibitor, on adjuvant-induced arthritis in rats , 2012, Inflammation Research.

[13]  S. Yagihashi,et al.  Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat , 2012, PloS one.

[14]  John P. Overington,et al.  ChEMBL: a large-scale bioactivity database for drug discovery , 2011, Nucleic Acids Res..

[15]  K. Ramana,et al.  Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. , 2011, Free radical biology & medicine.

[16]  Michael C Hutter,et al.  Graph-based similarity concepts in virtual screening. , 2011, Future medicinal chemistry.

[17]  David S. Wishart,et al.  DrugBank 3.0: a comprehensive resource for ‘Omics’ research on drugs , 2010, Nucleic Acids Res..

[18]  Mi Kyeong Lee,et al.  Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells , 2011, Journal of Natural Medicines.

[19]  R. Guerrant,et al.  Adenosine Deaminase Inhibition Prevents Clostridium difficile Toxin A-Induced Enteritis in Mice , 2010, Infection and Immunity.

[20]  T Scior,et al.  Reverse pharmacognosy: another way to harness the generosity of nature. , 2010, Current pharmaceutical design.

[21]  G. Layton,et al.  A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis , 2010, The British journal of dermatology.

[22]  P. Suryanarayana,et al.  Inhibition of aldose reductase by dietary antioxidant curcumin: Mechanism of inhibition, specificity and significance , 2009, FEBS letters.

[23]  J. O'Donnell,et al.  Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling , 2009, Journal of Pharmacology and Experimental Therapeutics.

[24]  K. Suckling Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic , 2009, Expert opinion on investigational drugs.

[25]  A. Ray,et al.  Glycogen synthase kinase 3: more than a namesake , 2009, British journal of pharmacology.

[26]  Izhar Wallach,et al.  The protein-small-molecule database, a non-redundant structural resource for the analysis of protein-ligand binding , 2009, Bioinform..

[27]  John B Hallagan,et al.  Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[28]  H. Korting,et al.  Evidenz-basierte Kosmetika: Konzept und Anwendung bei den Zielstellungen Licht-geschädigte Altershaut und Xerosis , 2009, Wiener klinische Wochenschrift.

[29]  J. Fowlkes,et al.  Matrix metalloproteinases: their potential role in the pathogenesis of diabetic nephropathy , 2009, Endocrine.

[30]  A. Blokland,et al.  Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion. , 2008, European journal of pharmacology.

[31]  A. Kralli,et al.  ERRα: a metabolic function for the oldest orphan , 2008, Trends in Endocrinology & Metabolism.

[32]  M. Weiss,et al.  Pentostatin in chronic lymphocytic leukemia , 2008, Expert opinion on drug metabolism & toxicology.

[33]  S. Tanabe,et al.  Macrophage tolerance response to Aggregatibacter actinomycetemcomitans lipopolysaccharide induces differential regulation of tumor necrosis factor-alpha, interleukin-1 beta and matrix metalloproteinase 9 secretion. , 2008, Journal of periodontal research.

[34]  F. Bosetti,et al.  Genetic deletion or pharmacological inhibition of cyclooxygenase‐1 attenuate lipopolysaccharide‐ induced inflammatory response and brain injury , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  Luc Morin-Allory,et al.  Reverse pharmacognosy: identifying biological properties for plants by means of their molecule constituents: application to meranzin. , 2007, Planta medica.

[36]  F. Salemme,et al.  A comparison of the chemical properties of drugs and FEMA/FDA notified GRAS chemical compounds used in the food industry. , 2007, Food and Chemical Toxicology.

[37]  R. Parker,et al.  Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 , 2007, Nature.

[38]  Michael J. Keiser,et al.  Relating protein pharmacology by ligand chemistry , 2007, Nature Biotechnology.

[39]  Xin Wen,et al.  BindingDB: a web-accessible database of experimentally determined protein–ligand binding affinities , 2006, Nucleic Acids Res..

[40]  M. Melzig,et al.  [Inhibitors of alpha-amylase from plants--a possibility to treat diabetes mellitus type II by phytotherapy?]. , 2007, Wiener medizinische Wochenschrift.

[41]  E. Mazzon,et al.  Inhibition of glycogen synthase kinase‐3β attenuates the development of carrageenan‐induced lung injury in mice , 2006 .

[42]  T. Kanayama,et al.  Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARγ‐specific retinoid, but not by ER35794, an RXR‐selective agonist , 2006, International journal of dermatology.

[43]  S. Milligan,et al.  The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. , 2006, The Journal of endocrinology.

[44]  Stephen R. Johnson,et al.  NMR structure of a potent small molecule inhibitor bound to human keratinocyte fatty acid-binding protein. , 2006, Journal of medicinal chemistry.

[45]  R. Preissner,et al.  Photoactivation of an Inhibitor of the 12/15‐Lipoxygenase Pathway , 2006, Chembiochem : a European journal of chemical biology.

[46]  G. Godeau,et al.  Fucoidan a sulfated polysaccharide from brown algae is a potent modulator of connective tissue proteolysis. , 2006, Archives of biochemistry and biophysics.

[47]  Q. Do,et al.  Reverse Pharmacognosy: Application of Selnergy, a New Tool for Lead Discovery. The Example of ε-Viniferin , 2005 .

[48]  J. Kaiser Chemists Want NIH to Curtail Database , 2005, Science.

[49]  J. Aubin,et al.  Estrogen Receptor-Related Receptor α: A Mediator of Estrogen Response in Bone , 2005 .

[50]  J. Suttles,et al.  The Fatty Acid-binding Protein, aP2, Coordinates Macrophage Cholesterol Trafficking and Inflammatory Activity , 2005, Journal of Biological Chemistry.

[51]  Y. Ohizumi,et al.  Powerful hepatoprotective and hepatotoxic plant oligostilbenes, isolated from the Oriental medicinal plantVitis coignetiae (Vitaceae) , 1995, Experientia.

[52]  Robert J. Jilek,et al.  "Lead hopping". Validation of topomer similarity as a superior predictor of similar biological activities. , 2004, Journal of medicinal chemistry.

[53]  Philippe Bernard,et al.  Pharmacognosy and reverse pharmacognosy: a new concept for accelerating natural drug discovery. , 2004, IDrugs : the investigational drugs journal.

[54]  Jérôme Hert,et al.  Comparison of Fingerprint-Based Methods for Virtual Screening Using Multiple Bioactive Reference Structures , 2004, J. Chem. Inf. Model..

[55]  Kenji Matsumoto,et al.  Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal model. , 2003, Journal of experimental therapeutics & oncology.

[56]  F. Berthou,et al.  Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. , 2003, Life sciences.

[57]  A. Mai,et al.  Synthesis and biological evaluation of enantiomerically pure pyrrolyl-oxazolidinones as a new class of potent and selective monoamine oxidase type A inhibitors. , 2003, Farmaco.

[58]  J. Bajorath,et al.  Mini-fingerprints for virtual screening: Design principles and generation of novel prototypes based on information theory , 2003, SAR and QSAR in environmental research.

[59]  C. Hasler Functional foods: benefits, concerns and challenges-a position paper from the american council on science and health. , 2002, The Journal of nutrition.

[60]  M. Itoh,et al.  Mechanisms of inhibitory activity of the aldose reductase inhibitor, epalrestat, on high glucose-mediated endothelial injury: neutrophil-endothelial cell adhesion and surface expression of endothelial adhesion molecules. , 2002, Journal of diabetes and its complications.

[61]  P. Sampson,et al.  Methionine in and out of proteins: targets for drug design. , 2002, Current medicinal chemistry.

[62]  F. Nepveu,et al.  Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media. , 2002, Journal of agricultural and food chemistry.

[63]  F. Mentz,et al.  Comparative Antiproliferative and Apoptotic Effects of Resveratrol, ϵ-viniferin and Vine-shots Derived Polyphenols (Vineatrols) on Chronic B Lymphocytic Leukemia Cells and Normal Human Lymphocytes , 2002, Leukemia & lymphoma.

[64]  J. Ram,et al.  Effect of Aldose Reductase Inhibition on Interleukin-1β-Induced Nitric Oxide (NO) Synthesis in Vascular Tissue , 2002, International journal of experimental diabetes research.

[65]  T. Scior,et al.  Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors. , 2001, Phytochemistry.

[66]  Matthias Rarey,et al.  Similarity searching in large combinatorial chemistry spaces , 2001, J. Comput. Aided Mol. Des..

[67]  P. Cohen Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. , 2001, Medical hypotheses.

[68]  Tudor I. Oprea,et al.  The Design of Leadlike Combinatorial Libraries. , 1999, Angewandte Chemie.

[69]  C. Koboldt,et al.  Pharmacological analysis of cyclooxygenase-1 in inflammation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[70]  Robert D. Clark,et al.  OptiSim: An Extended Dissimilarity Selection Method for Finding Diverse Representative Subsets , 1997, J. Chem. Inf. Comput. Sci..

[71]  H. Matter,et al.  Selecting optimally diverse compounds from structure databases: a validation study of two-dimensional and three-dimensional molecular descriptors. , 1997, Journal of medicinal chemistry.

[72]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .

[73]  R. L. Hall,et al.  FEMA GRAS--a GRAS assessment program for flavor ingredients. Flavor and Extract Manufacturers Association. , 1995, Regulatory toxicology and pharmacology : RTP.

[74]  G. Massiot,et al.  Pharmacognosie: Phytochimie, Plantes Médicinales: : By J. Bruneton, 2nd Edn, Tec Doc, Paris, 1993. 928pp. 78OF ISBN 2-85206-911-3. , 1994 .

[75]  P. Langcake Disease resistance of Vitis spp. and the production of the stress metabolites resveratrol, ε-viniferin, α-viniferin and pterostilbene , 1981 .

[76]  R. J. Pryce,et al.  The production of resveratrol and the viniferins by grapevines in response to ultraviolet irradiation , 1977 .