An expanding role for mTOR in cancer.
暂无分享,去创建一个
[1] J. Blenis,et al. Identification of S6 Kinase 1 as a Novel Mammalian Target of Rapamycin (mTOR)-phosphorylating Kinase* , 2005, Journal of Biological Chemistry.
[2] Robert T. Abraham,et al. Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 Is Mediated by p70S6 Kinase* , 2005, Journal of Biological Chemistry.
[3] J. Avruch,et al. Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency* , 2005, Journal of Biological Chemistry.
[4] D. Sabatini,et al. Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site*♦ , 2005, Journal of Biological Chemistry.
[5] C. Proud,et al. The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses* , 2005, Journal of Biological Chemistry.
[6] Joseph Avruch,et al. Rheb Binds and Regulates the mTOR Kinase , 2005, Current Biology.
[7] E. Raymond,et al. mTOR-targeted therapy of cancer with rapamycin derivatives. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.
[8] P. Burger,et al. Lhermitte-Duclos Disease: A Report of 31 Cases with Immunohistochemical Analysis of the PTEN/AKT/mTOR Pathway , 2005, Journal of neuropathology and experimental neurology.
[9] T. Ludwig,et al. Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size , 2005, Molecular and Cellular Biology.
[10] C. Kenyon. The Plasticity of Aging: Insights from Long-Lived Mutants , 2005, Cell.
[11] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[12] N. Ruderman,et al. AMPK, the metabolic syndrome and cancer. , 2005, Trends in pharmacological sciences.
[13] C. Lindsley,et al. Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members. , 2005, Molecular cancer therapeutics.
[14] J. Blenis,et al. mTOR, translational control and human disease. , 2005, Seminars in cell & developmental biology.
[15] E. Hafen,et al. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. , 2004, Genes & development.
[16] E. Hafen,et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. , 2004, Genes & development.
[17] E. Rowinsky. Targeting the molecular target of rapamycin (mTOR) , 2004, Current opinion in oncology.
[18] R. Loewith,et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.
[19] G. Thomas,et al. Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development , 2004, Molecular and Cellular Biology.
[20] C. Thompson,et al. Putting the rap on Akt. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[21] D. Pan,et al. Tsc2 is not a critical target of Akt during normal Drosophila development. , 2004, Genes & development.
[22] J. Dancey. Molecular targeting: PI3 kinase pathway. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[23] B. Hemmings,et al. Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase*♦ , 2004, Journal of Biological Chemistry.
[24] J. Auwerx,et al. Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[25] T. Hunter,et al. Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies , 2004, Current Biology.
[26] Shunyou Wang,et al. PTENless means more. , 2004, Developmental biology.
[27] S. Chan,et al. Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer , 2004, British Journal of Cancer.
[28] Johan Auwerx,et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[29] N. Sonenberg,et al. Upstream and downstream of mTOR. , 2004, Genes & development.
[30] Di Chen,et al. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span , 2004, Development.
[31] M. Murakami,et al. mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells , 2004, Molecular and Cellular Biology.
[32] C. Haipek,et al. Functional significance of S6K overexpression in meningioma progression , 2004, Annals of neurology.
[33] D. Guertin,et al. Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton , 2004, Current Biology.
[34] I. Gout,et al. The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins , 2004, The Journal of cell biology.
[35] William R Sellers,et al. The biology and clinical relevance of the PTEN tumor suppressor pathway. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[36] R. DePinho,et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. , 2004, Cancer cell.
[37] R. DePinho,et al. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. , 2004, Genes & development.
[38] S. Benzer,et al. Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway , 2004, Current Biology.
[39] B. Hemmings,et al. Advances in protein kinase B signalling: AKTion on multiple fronts. , 2004, Trends in biochemical sciences.
[40] M. Bjornsti,et al. The tor pathway: a target for cancer therapy , 2004, Nature Reviews Cancer.
[41] P. Pandolfi,et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis , 2004, Nature Medicine.
[42] H. Zentgraf,et al. Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies , 2004, Virchows Archiv.
[43] N. Sonenberg,et al. eIF4E – from translation to transformation , 2004, Oncogene.
[44] J. Blenis,et al. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression , 2004, Oncogene.
[45] D. V. van Aalten,et al. PDK1, the master regulator of AGC kinase signal transduction. , 2004, Seminars in cell & developmental biology.
[46] Stefano Fumagalli,et al. S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway , 2004, Molecular and Cellular Biology.
[47] S. Lowe,et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy , 2004, Nature.
[48] Lewis C Cantley,et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[49] Jérôme Boudeau,et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 , 2004, The EMBO journal.
[50] G. Mills,et al. Determinants of Rapamycin Sensitivity in Breast Cancer Cells , 2004, Clinical Cancer Research.
[51] Tibor Vellai,et al. Genetics: Influence of TOR kinase on lifespan in C. elegans , 2003, Nature.
[52] C. J. Barnes,et al. Epidermal growth factor receptor family tyrosine kinases as signal integrators and therapeutic targets , 2003, Cancer and Metastasis Reviews.
[53] C. Thompson,et al. Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. , 2003, Cancer research.
[54] K. Inoki,et al. TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.
[55] Hongbing Zhang,et al. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. , 2003, The Journal of clinical investigation.
[56] P. Hammerman,et al. Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival , 2003, Molecular and Cellular Biology.
[57] G. Semenza. Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.
[58] M. Hung,et al. Dysregulation of cellular signaling by HER2/neu in breast cancer. , 2003, Seminars in oncology.
[59] Charis Eng,et al. PTEN: One Gene, Many Syndromes , 2003, Human mutation.
[60] William R Sellers,et al. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. , 2003, Cancer cell.
[61] J. Stock,et al. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. , 2003, The Journal of clinical investigation.
[62] Marketa Zvelebil,et al. Phosphoinositide 3-kinase signalling--which way to target? , 2003, Trends in pharmacological sciences.
[63] Jennifer Skeen,et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. , 2003, Genes & development.
[64] Shile Huang,et al. Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1). , 2003, Molecular cell.
[65] V. Krymskaya,et al. Lymphangioleiomyomatosis: a complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation. , 2003, American journal of respiratory cell and molecular biology.
[66] Paul Tempst,et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. , 2003, Molecular cell.
[67] R. Offringa,et al. Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. , 2003, Blood.
[68] Shile Huang,et al. Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways. , 2003, Cancer research.
[69] M. Birnbaum,et al. Role of Akt/protein kinase B in metabolism , 2002, Trends in Endocrinology & Metabolism.
[70] G. Thomas,et al. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. , 2002, Genes & development.
[71] L. Aicher,et al. Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. , 2002, Cancer research.
[72] Christine C. Hudson,et al. Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin , 2002, Molecular and Cellular Biology.
[73] J. Crespo,et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. , 2002, Molecular cell.
[74] R. Bookstein,et al. Mutations to CCI-779 PTEN Enhanced Sensitivity of Multiple Myeloma Cells Containing Updated Version , 2002 .
[75] In-Hyun Park,et al. Regulation of Ribosomal S6 Kinase 2 by Mammalian Target of Rapamycin* , 2002, The Journal of Biological Chemistry.
[76] J. Avruch,et al. Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action , 2002, Cell.
[77] D. Sabatini,et al. mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.
[78] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[79] P. Kang,et al. Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice , 2002, Molecular and Cellular Biology.
[80] Kathryn E. Hentges,et al. FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[81] M. Birnbaum,et al. Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice* , 2001, The Journal of Biological Chemistry.
[82] A. Marette,et al. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. , 2001, The Journal of biological chemistry.
[83] E. Furth,et al. Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα , 2001, Nature Medicine.
[84] R. Valeri,et al. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. , 2001, American journal of physiology. Renal physiology.
[85] I. Roninson,et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. , 2001, Genes & development.
[86] J. Blenis,et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[87] Hong Wu,et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[88] T. Haruta,et al. Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin , 2001, Molecular and Cellular Biology.
[89] K. Kaestner,et al. Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ) , 2001 .
[90] H. Watkins,et al. Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. , 2001, Human molecular genetics.
[91] Shile Huang,et al. p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. , 2001, Cancer research.
[92] C. Thompson,et al. Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology* , 2001, The Journal of Biological Chemistry.
[93] P. Vogt,et al. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[94] R. Burcelin,et al. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice , 2000, Nature.
[95] Y. Chen,et al. Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis. , 2000, Journal of the National Cancer Institute.
[96] A. Newton,et al. Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site* , 2000, The Journal of Biological Chemistry.
[97] D. Bigner,et al. Molecular pathogenesis of malignant gliomas. , 1999, Current opinion in oncology.
[98] M. Knowles,et al. Somatic mutation of PTEN in bladder carcinoma , 1999, British Journal of Cancer.
[99] A. Casamayor,et al. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2 , 1999, Current Biology.
[100] Hui Ma,et al. Chemoattractant‐mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium , 1999, The EMBO journal.
[101] Stefano Fumagalli,et al. Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase , 1998, The EMBO journal.
[102] P. Devreotes,et al. A novel cytosolic regulator, Pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium. , 1997, Genes & development.
[103] M. Wigler,et al. PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer , 1997, Science.
[104] J. Blenis,et al. Structural and functional analysis of pp70S6k. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[105] J. Cheng,et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas , 1995, International journal of cancer.
[106] J. Avruch,et al. Multiple independent inputs are required for activation of the p70 S6 kinase , 1995, Molecular and cellular biology.
[107] E. Anderson. Hudson et al. , 1977 .
[108] L. S. Harrington,et al. Restraining PI3K: mTOR signalling goes back to the membrane. , 2005, Trends in biochemical sciences.
[109] Kun-Liang Guan,et al. Dysregulation of the TSC-mTOR pathway in human disease , 2004, Nature Genetics.
[110] D. Guertin,et al. 7 Growth Control through the mTOR Network , 2004 .
[111] M. Raff,et al. Cell growth : control of cell size , 2004 .
[112] P. Houghton,et al. p 53 / p 21 CIP 1 Cooperate in Enforcing Rapamycin-induced G 1 Arrest and Determine the Cellular Response to Rapamycin 1 , 2001 .
[113] Joe W. Gray,et al. PIK3CA is implicated as an oncogene in ovarian cancer , 1999, Nature Genetics.