Sensorineural hearing loss in very low birth weight infants with histological chorioamnionitis

Abstract Objective: Histological chorioamnionitis (HCAM) has been associated with inflammatory diseases of preterm infants. Recently we have observed that it increased the risk of speech delay and hearing loss. So the aim of this study was to evaluate the relationship between sensorineural hearing loss (SNHL) of VLBW infants and HCAM. Methods: We performed an observational study on VLBW infants admitted to the NICU of Padua. Each patient with HCAM was matched with one control without HCAM. All infants underwent hearing screening before discharge by means of automated transient–evoked otoacustic emissions and automated auditory brainstem responses, which were repeated at 3 and 6 months of age with tympanometry measurement. Incidence of SNHL at 6 months of age was compared in the 2 groups and risk factors for hearing loss were studied. Results: Two of 77 (2.6%) newborns with HCAM e 6/73 (8.2%) without it presented SNHL at 6 months of corrected age (p = 0.16). Multivariable logistic regression analysis identified surgical ligation of patent ductus arteriosus (PDA) as independent predictors of SNHL (OR: 5.75, 95% CI 1.34–24.84, p = 0.02), whereas the effect of HCAM on SNHL was only near to statistical significance level. Conclusions: Surgical ligation of PDA is associated with an increased risk of SNHL in VLBW infants, regardless of HCAM.

[1]  A. Jefferies.  Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. , 2012, Paediatrics & child health.

[2]  V. Zanardo,et al.  Consequences in Infants That Were Intrauterine Growth Restricted , 2011, Journal of pregnancy.

[3]  V. Zanardo,et al.  Chorioamnionitis and cerebral palsy: a meta-analysis. , 2010, Obstetrics and gynecology.

[4]  K. Watterberg.  Postnatal Corticosteroids to Prevent or Treat Bronchopulmonary Dysplasia , 2010, Pediatrics.

[5]  A. Goedegebure,et al.  Risk factors for sensorineural hearing loss in NICU infants compared to normal hearing NICU controls. , 2010, International journal of pediatric otorhinolaryngology.

[6]  V. Zanardo,et al.  Preterm premature rupture of membranes, chorioamnion inflammatory scores and neonatal respiratory outcome , 2010, BJOG : an international journal of obstetrics and gynaecology.

[7]  C. Robertson,et al.  Permanent Bilateral Sensory and Neural Hearing Loss of Children After Neonatal Intensive Care Because of Extreme Prematurity: A Thirty-Year Study , 2009, Pediatrics.

[8]  A. Suppiej,et al.  Neurodevelopmental outcome in preterm histological chorioamnionitis. , 2009, Early human development.

[9]  J. Oghalai,et al.  Hearing loss in children with very low birth weight: current review of epidemiology and pathophysiology , 2008, Archives of Disease in Childhood Fetal and Neonatal Edition.

[10]  B. Olusanya.  Newborns at risk of sensorineural hearing loss in low-income countries , 2008, Archives of Disease in Childhood.

[11]  J. Fawke.  Neurological outcomes following preterm birth. , 2007, Seminars in fetal & neonatal medicine.

[12]  K. Hsu,et al.  Effects of Neonatal Corticosteroid Treatment on Hippocampal Synaptic Function , 2007, Pediatric Research.

[13]  E. Hille,et al.  Prevalence and independent risk factors for hearing loss in NICU infants , 2007, Acta paediatrica.

[14]  M. Kenna,et al.  Anomalies of the middle and inner ear. , 2007, Otolaryngologic clinics of North America.

[15]  R. Redline.  Inflammatory responses in the placenta and umbilical cord. , 2006, Seminars in fetal & neonatal medicine.

[16]  M. Hildesheimer,et al.  Low prevalence of hearing impairment among very low birthweight infants as detected by universal neonatal hearing screening , 2006, Archives of Disease in Childhood - Fetal and Neonatal Edition.

[17]  M. Walsh,et al.  Validation of the National Institutes of Health Consensus Definition of Bronchopulmonary Dysplasia , 2005, Pediatrics.

[18]  A. LaCroix,et al.  Risk Factors Associated with Acute Pyelonephritis in Healthy Women , 2005, Annals of Internal Medicine.

[19]  C. McEvoy,et al.  A randomized trial of moderately early low-dose dexamethasone therapy in very low birth weight infants: dynamic pulmonary mechanics, oxygenation, and ventilation. , 2002, Pediatrics.

[20]  A. Summerfield,et al.  Prevalence of permanent childhood hearing impairment in the United Kingdom and implications for universal neonatal hearing screening: questionnaire based ascertainment study. , 2001, BMJ : British Medical Journal.

[21]  R. Harrison,et al.  Differential vulnerability of inner and outer hair cell systems to chronic mild hypoxia and glutamate ototoxicity: insights into the cause of auditory neuropathy. , 2001, The Journal of otolaryngology.

[22]  K. Barrington.  The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs , 2001, BMC pediatrics.

[23]  R. Romero,et al.  The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. , 2000, American journal of obstetrics and gynecology.

[24]  F. Torricelli,et al.  Inherited susceptibility to aminoglycoside ototoxicity: genetic heterogeneity and clinical implications. , 1999, American journal of otolaryngology.

[25]  C. Langston,et al.  Practice guideline for examination of the placenta: developed by the Placental Pathology Practice Guideline Development Task Force of the College of American Pathologists. , 1997, Archives of pathology & laboratory medicine.

[26]  L. D. de Vries,et al.  Relationship of serum bilirubin levels and hearing impairment in newborn infants. , 1987, Early human development.

[27]  Principles and Guidelines for Early Hearing Detection and Intervention Programs , 2019 .

[28]  E. Zimmerman,et al.  Ototoxicity in preterm infants: effects of genetics, aminoglycosides, and loud environmental noise , 2013, Journal of Perinatology.

[29]  J. Stockman.  Neurosensory Impairment after Surgical Closure of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants: Results from the Trial of Indomethacin Prophylaxis in Preterms , 2008 .