Improving acquisition time of the frequency-specific auditory brainstem response through simultaneous independently random toneburst sequences

The frequency-specific auditory brainstem response (ABR) is an objective electroencephalographic (EEG) method for estimating auditory thresholds when behavioral thresholds are not attainable, primarily in infants and toddlers. It is recorded by repeatedly presenting brief, band-limited tonebursts and averaging the scalp potential response. In a typical ABR evaluation, measurements are made at multiple intensities, at multiple frequencies, and in both ears, leading to a large combinatorial space and long test times. Here, we present a method of recording the responses at five frequencies in both ears simultaneously, along with preliminary data demonstrating its effectiveness. We created ten toneburst trains—five octave frequencies (500–8000 Hz) by two ears—for simultaneous presentation. Importantly, the toneburst timing for each train was dictated by an independent random process, rather than being periodic. Independent sequences allow separate computation of the ABR to each of the toneburst trains as the cross-correlation of its timing sequence and the EEG recording. Early results suggest substantial improvements in recording time, particularly at lower stimulus intensities. It also appears that cochlear spread of excitation—a problem at high intensities—is mitigated by our method. This improvement in place specificity is predicted by modeling of auditory nerve activity.The frequency-specific auditory brainstem response (ABR) is an objective electroencephalographic (EEG) method for estimating auditory thresholds when behavioral thresholds are not attainable, primarily in infants and toddlers. It is recorded by repeatedly presenting brief, band-limited tonebursts and averaging the scalp potential response. In a typical ABR evaluation, measurements are made at multiple intensities, at multiple frequencies, and in both ears, leading to a large combinatorial space and long test times. Here, we present a method of recording the responses at five frequencies in both ears simultaneously, along with preliminary data demonstrating its effectiveness. We created ten toneburst trains—five octave frequencies (500–8000 Hz) by two ears—for simultaneous presentation. Importantly, the toneburst timing for each train was dictated by an independent random process, rather than being periodic. Independent sequences allow separate computation of the ABR to each of the toneburst trains as the ...