Griseofulvin in the prevention of experimental human dermatophytosis.

The efficacy of griseofulvin administered to prevent experimentally induced inflammatory dermatophytosis was assessed in a randomized, double-blind trial involving six drug-treated and six placebo-treated subjects. Volunteers were challenged with a standard inoculum of spores from a zoophilic (granular) strain of Trichophyton mentagrophytes . One-gram doses of micronized griseofulvin daily provided significant protection against the development of florid inflammatory lesions ( P P