Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators
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[1] Aaron J Johnson,et al. GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts. , 2019, Blood.
[2] M. Gooderham,et al. Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) as a therapeutic target in psoriasis: randomized, controlled investigation using namilumab, a specific human anti‐GM‐CSF monoclonal antibody† , 2018, The British journal of dermatology.
[3] Valérie Guyot,et al. A Versatile Safeguard for Chimeric Antigen Receptor T-Cell Immunotherapies , 2018, Scientific Reports.
[4] C. Doglioni,et al. Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells , 2018, Nature Medicine.
[5] M. Sadelain,et al. CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade , 2018, Nature Medicine.
[6] K. Davis,et al. Tisagenlecleucel in Children and Young Adults with B‐Cell Lymphoblastic Leukemia , 2018, The New England journal of medicine.
[7] Stephen J. Schuster,et al. Chimeric Antigen Receptor T Cells in Refractory B‐Cell Lymphomas , 2017, The New England journal of medicine.
[8] R. Levy,et al. Axicabtagene Ciloleucel CAR T‐Cell Therapy in Refractory Large B‐Cell Lymphoma , 2017, The New England journal of medicine.
[9] M. Wurfel,et al. Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells. , 2017, Cancer discovery.
[10] N. Frey. Cytokine release syndrome: Who is at risk and how to treat. , 2017, Best practice & research. Clinical haematology.
[11] D. Teachey,et al. Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function. , 2017, Cytotherapy.
[12] T. Huizinga,et al. Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis , 2017, Arthritis Research & Therapy.
[13] Mithat Gönen,et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection , 2017, Nature.
[14] D. Teachey,et al. Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia , 2017, Critical care medicine.
[15] Ming-Ru Wu,et al. Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell–Treated Mice , 2016, The Journal of Immunology.
[16] A. Zhang,et al. Third-generation CD28/4-1BB chimeric antigen receptor T cells for chemotherapy relapsed or refractory acute lymphoblastic leukaemia: a non-randomised, open-label phase I trial protocol , 2016, BMJ Open.
[17] Burkhard Becher,et al. GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation. , 2016, Immunity.
[18] G. Wertheim,et al. Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia. , 2016, Cancer discovery.
[19] K. Curran,et al. Toxicity and management in CAR T-cell therapy , 2016, Molecular therapy oncolytics.
[20] S. Amor,et al. GM‐CSF promotes migration of human monocytes across the blood brain barrier , 2015, European journal of immunology.
[21] J. Hamilton. GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential , 2015, Expert review of clinical immunology.
[22] S. Grupp,et al. Refractory Cytokine Release Syndrome in Recipients of Chimeric Antigen Receptor (CAR) T Cells , 2014 .
[23] S. Grupp,et al. Current concepts in the diagnosis and management of cytokine release syndrome. , 2014, Blood.
[24] M. Teixeira,et al. The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases , 2014, Expert review of clinical immunology.
[25] Qing He,et al. Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia , 2014, Science Translational Medicine.
[26] Jun S. Liu,et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery , 2013 .
[27] Bernd Hauck,et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. , 2013, The New England journal of medicine.
[28] A. Bagg,et al. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. , 2011, The New England journal of medicine.
[29] F. Magrini,et al. Extended Report , 2011 .
[30] C. Ding,et al. Tocilizumab: A Review of Its Safety and Efficacy in Rheumatoid Arthritis , 2010, Clinical medicine insights. Arthritis and musculoskeletal disorders.
[31] S. Amini,et al. Monocyte chemoattractant protein-1 (MCP-1): an overview. , 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
[32] Irah L. King,et al. Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease. , 2009, Blood.
[33] E. Ponomarev,et al. GM-CSF Production by Autoreactive T Cells Is Required for the Activation of Microglial Cells and the Onset of Experimental Autoimmune Encephalomyelitis1 , 2007, The Journal of Immunology.
[34] S. Salzano,et al. Expression of GM-CSF receptor and "in vitro" effects of GM-CSF on human fibroblasts. , 1998, Life sciences.
[35] M. Hüfner,et al. [Plasma GM-CSF concentrations in rheumatoid arthritis, systemic lupus erythematosus and spondyloarthropathy]. , 1992, Zeitschrift fur Rheumatologie.
[36] G. Firestein,et al. Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions. , 1989, The Journal of clinical investigation.
[37] M. Vadas,et al. The detection and initial characterization of colony-stimulating factors in synovial fluid. , 1988, Clinical and experimental immunology.
[38] C. R. Clark,et al. Granulocyte/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor. , 1988, Blood.
[39] A. Roberts,et al. Targeting GM-CSF in inflammatory diseases , 2016, Nature Reviews Rheumatology.
[40] J J Gómez-Reino Carnota,et al. [Genetics of rheumatoid arthritis]. , 2000, Medicina clinica.