LYMPHOEPITHELIOMA-LIKE CARCINOMA OF THE UTERINE CERVIX SHOWING NEGATIVE EPSTEIN- BARR VIRUS AND POSITIVE HUMAN PAPILLOMA VIRUS PROPERTIES

Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rarely seen variant of squamous cell carcinoma. It differs from the usual squamous cell carcinoma with its better prognosis, and different clinical behavior and morphology. Different association rates have been reported between LELC and Epstein-Barr virus and human papilloma virus in the Asian and Western countries; however, the relationship remains controversial. In order to make a contribution to the further studies on the etiopathogenesis of LELC, we, herein,present a 62-year-old Turkish female with LELC of the uterine cervix, which is negative for Epstein-Barr virus but positive for human papillomavirus virus.

[1]  Li‐yu Lee,et al.  Does Epstein-Barr Virus Play a Role in Lymphoepithelioma-like Carcinoma of the Uterine Cervix? , 2009, International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.

[2]  J. Dietl,et al.  Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus and high-risk human papilloma virus infection , 2008, Archives of Gynecology and Obstetrics.

[3]  T. Teune,et al.  Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus, but presence of a multiple human papillomavirus infection. , 2005, Gynecologic oncology.

[4]  V. Anaf,et al.  Lymphoepithelioma‐like carcinoma of the cervix with prominent eosinophilic infiltrate: an HPV‐18 associated case , 2002, Acta obstetricia et gynecologica Scandinavica.

[5]  Y. Soong,et al.  Lymphoepithelioma‐like carcinoma of the uterine cervix , 1997, Cancer.

[6]  M. Gaffey,et al.  The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas. , 1995, American journal of clinical pathology.

[7]  S. Hoisington,et al.  Uterine cervical lymphoepithelial-like carcinoma. Absence of Epstein-Barr virus genomes. , 1993, American journal of clinical pathology.

[8]  H. Frierson,et al.  Analysis of Lymphoepithelioma and Lymphoepithelioma‐like Carcinomas for Epstein‐Barr Viral Genomes by in situ Hybridization , 1989, The American journal of surgical pathology.

[9]  G. Sakamoto,et al.  Circumscribed carcinoma of the uterine cervix, with marked lymphocytic infiltration , 1977, Cancer.

[10]  J. Kitawaki,et al.  Lymphoepithelial-like carcinoma of the uterine cervix; a case report. , 2011, European journal of gynaecological oncology.

[11]  J. Noël,et al.  Evidence of human papilloma virus infection but lack of Epstein-Barr virus in lymphoepithelioma-like carcinoma of uterine cervix: report of two cases and review of the literature. , 2001, Human pathology.