THz Chemical Imaging for Biological Applications

THz spectroscopy is advantageous in analytical chemistry because it can detect and identify intermolecular interactions in chemical compounds, such as hydrogen bonds and hydrations, and molecular networks. Recent advances in THz components, such as ultrashort pulsed lasers and photoconductive antennas, have improved the sensitivity of THz time-domain (TDS) spectroscopy and have made the THz chemical imaging possible. THz chemical imaging can reveal hydrogen bond distributions and will be a very powerful tool in biology, pharmacology, and life sciences. THz-TDS is also promising for the quantitative chemical analysis and detection of molecules and clusters in nanospace and ice.

[1]  Y. C. Shen,et al.  Chemical mapping using reflection terahertz pulsed imaging , 2005 .

[2]  P. Taday,et al.  Understanding the influence of polymorphism on phonon spectra: lattice dynamics calculations and terahertz spectroscopy of carbamazepine. , 2006, The journal of physical chemistry. B.

[3]  Edwin J. Heilweil,et al.  Terahertz spectroscopy of solid serine and cysteine , 2006 .

[4]  P. Taday,et al.  Temperature dependent terahertz pulsed spectroscopy of carbamazepine , 2005 .

[5]  Hiromasa Ito,et al.  Frequency-agile terahertz-wave spectrometer for high-resolution gas sensing , 2007 .

[6]  Radhakrishnan Balu,et al.  High-resolution terahertz spectroscopy of crystalline trialanine: extreme sensitivity to beta-sheet structure and cocrystallized water. , 2006, Journal of the American Chemical Society.

[7]  Daniel R. Grischkowsky,et al.  Characterization of an optoelectronic terahertz beam system , 1990 .

[8]  C. Otani,et al.  Noninvasive Mail Inspection System with Terahertz Radiation , 2009, Applied spectroscopy.

[9]  C. Otani,et al.  Terahertz imaging diagnostics of the cancer tissues with chemometrics technique , 2007, 2006 Joint 31st International Conference on Infrared Millimeter Waves and 14th International Conference on Teraherz Electronics.

[10]  Emi Tamechika,et al.  Quantitative Analysis of Amino Acids in Dietary Supplements Using Terahertz Time-domain Spectroscopy , 2011, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[11]  D. Grischkowsky,et al.  Far-infrared time-domain spectroscopy with terahertz beams of dielectrics and semiconductors , 1990 .

[12]  M. Nuss,et al.  Imaging with terahertz waves. , 1995, Optics letters.

[13]  F. Keilmann,et al.  Near-field probing of vibrational absorption for chemical microscopy , 1999, Nature.

[14]  Isao Tomita,et al.  Terahertz notch filter using intermolecular hydrogen bonds in a sucrose crystal. , 2006, Optics express.

[15]  Component spatial pattern analysis of chemicals by use of two-dimensional electro-optic terahertz imaging. , 2005, Applied optics.

[16]  K. Ajito,et al.  Terahertz Time-domain Spectra of Aromatic Carboxylic Acids Incorporated in Nano-sized Pores of Mesoporous Silicate , 2007, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[17]  Okan Esenturk,et al.  Applications of terahertz spectroscopy in biosystems. , 2007, Chemphyschem : a European journal of chemical physics and physical chemistry.

[18]  Kodo Kawase,et al.  Component spatial pattern analysis of chemicals using terahertz spectroscopic imaging , 2003 .

[19]  Ruey-Beei Wu,et al.  Terahertz Microchip for Illicit Drug Detection , 2006, IEEE Photonics Technology Letters.

[20]  Hideki Hirori,et al.  Attenuated Total Reflection Spectroscopy in Time Domain Using Terahertz Coherent Pulses , 2004 .

[21]  Grischkowsky,et al.  THz commensurate echoes: Periodic rephasing of molecular transitions in free-induction decay. , 1991, Physical review letters.

[22]  Darya A. Prokhorova,et al.  Solid-state modeling of the terahertz spectrum of the high explosive HMX. , 2006, The journal of physical chemistry. A.

[23]  Dwight L. Woolard,et al.  Chapter 2 Bio-molecular devices for terahertz frequency sensing , 2007 .

[24]  Isao Tomita,et al.  Quantitative measurements of amino acids by terahertz time-domain transmission spectroscopy. , 2006, Analytical chemistry.

[25]  Yaochun Shen,et al.  Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging. , 2007, Journal of pharmaceutical sciences.

[26]  Martin Gruebele,et al.  Protein sequence- and pH-dependent hydration probed by terahertz spectroscopy. , 2008, Journal of the American Chemical Society.

[27]  Nobuyuki Akai,et al.  The effect of cooperative hydrogen bonding on the OH stretching-band shift for water clusters studied by matrix-isolation infrared spectroscopy and density functional theory. , 2005, Physical chemistry chemical physics : PCCP.

[28]  D. Grischkowsky,et al.  Terahertz time-domain spectroscopy of water vapor. , 1989, Optics letters.

[29]  G. Day,et al.  Terahertz time-domain spectroscopy and the quantitative monitoring of mechanochemical cocrystal formation. , 2007, Nature Materials.

[30]  Joo-Hiuk Son,et al.  Nanoparticle-enabled terahertz imaging for cancer diagnosis. , 2009, Optics express.

[31]  C. Sano,et al.  Effects of additives on the growth of L-glutamic acid crystals (β-form) , 1997 .

[32]  Mattias Beck,et al.  Imaging with a Terahertz quantum cascade laser. , 2004, Optics express.

[33]  Yuko Ueno,et al.  Analytical Terahertz Spectroscopy , 2008, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[34]  K. Ajito,et al.  Angle-dependent terahertz time-domain spectroscopy of amino acid single crystals. , 2006, The journal of physical chemistry. B.

[35]  E. Tamechika,et al.  Terahertz Spectroscopic Imaging of Polymorphic Forms in Pharmaceutical Crystals , 2011 .

[36]  K. Ajito,et al.  Terahertz Images of Biological Molecules: Frequency Dependence of Spatial Resolution Using a Tunable Terahertz Laser Source , 2008 .

[37]  S. Warren,et al.  Optical constants of ice from the ultraviolet to the microwave. , 1984, Applied optics.

[38]  M. J. Fitch,et al.  Wideband terahertz spectroscopy of explosives , 2007 .

[39]  Keisuke Tominaga,et al.  Terahertz time-domain spectroscopy of amino acids and polypeptides. , 2005, Biophysical journal.

[40]  James S. Harris,et al.  Biomedical terahertz imaging with a quantum cascade laser , 2006 .

[41]  K. Kawase,et al.  Non-destructive terahertz imaging of illicit drugs using spectral fingerprints. , 2003, Optics express.

[42]  M. Dressel,et al.  Spatial and spectral behavior of the optical near field studied by a terahertz near-field spectrometer , 2004 .

[43]  Richard G. Baraniuk,et al.  Gas sensing using terahertz time-domain spectroscopy , 1998 .

[44]  Won-Yong Chong,et al.  Compression of Pulsed Terahertz Image Using Discrete Wavelet Transform , 2007 .

[45]  V. Wallace,et al.  In vivo study of human skin using pulsed terahertz radiation , 2004, Physics in medicine and biology.

[46]  E. Linfield,et al.  Terahertz Pulsed Imaging of Skin Cancer in the Time and Frequency Domain , 2003, Journal of biological physics.

[47]  E. Heilweil,et al.  Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz , 2000 .

[48]  Microspectroscopy and imaging in the THz range using coherent CW radiation. , 2002, Physics in medicine and biology.

[49]  Masahiko Tani,et al.  Terahertz Time-Domain Spectroscopy of Solids: A Review , 2005 .

[50]  Martin Dressel,et al.  Far-infrared spectra of amino acids , 2005 .

[51]  Emma Pickwell-MacPherson,et al.  Terahertz pulsed imaging--a potential medical imaging modality? , 2009, Photodiagnosis and photodynamic therapy.

[52]  Jun-ichi Nishizawa,et al.  THz transmittance measurements of nucleobases and related molecules in the 0.4- to 5.8-THz region using a GaP THz wave generator , 2005 .

[53]  M. Nuss,et al.  Subpicosecond photoconducting dipole antennas , 1988 .

[54]  X-C Zhang,et al.  Identification and classification of chemicals using terahertz reflective spectroscopic focal-plane imaging system. , 2006, Optics express.

[55]  V. Wallace,et al.  Biomedical applications of terahertz technology , 2002, The 15th Annual Meeting of the IEEE Lasers and Electro-Optics Society.

[56]  B. Fischer,et al.  Far-infrared vibrational modes of DNA components studied by terahertz time-domain spectroscopy , 2002, Physics in medicine and biology.

[57]  R R Alfano,et al.  Torsional vibrational modes of tryptophan studied by terahertz time-domain spectroscopy. , 2004, Biophysical journal.

[58]  Ajay Nahata,et al.  Two-dimensional imaging of continuous-wave terahertz radiation using electro-optic detection , 2002 .

[59]  K. Humphreys,et al.  Medical applications of terahertz imaging: a review of current technology and potential applications in biomedical engineering , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[60]  Martin Koch,et al.  THz near-field imaging , 1998 .

[61]  E. Pickwell‐MacPherson,et al.  Terahertz pulsed spectroscopy of freshly excised human breast cancer. , 2009, Optics express.