A pore way to die

Like Jekyll to Hyde, mitochondria can change from acting as the cell's powerhouses to become merciless killers. Mice lacking this mechanism develop normally, and their hearts are resistant to pathological damage.

[1]  D. Green,et al.  The Pathophysiology of Mitochondrial Cell Death , 2004, Science.

[2]  J. Lemasters,et al.  Cyclophilin D as a drug target. , 2003, Current medicinal chemistry.

[3]  Tetsuya Watanabe,et al.  Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death , 2005, Nature.

[4]  A. Halestrap,et al.  The permeability transition pore complex: another view. , 2002, Biochimie.

[5]  Dean P. Jones,et al.  The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore , 2004, Nature.

[6]  M. Crompton,et al.  Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis. , 2004, The Biochemical journal.

[7]  Jeffrey Robbins,et al.  Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death , 2005, Nature.

[8]  A. Halestrap.  Mitochondrial permeability: Dual role for the ADP/ATP translocator? , 2004, Nature.

[9]  M. Crompton,et al.  Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. , 1988, The Biochemical journal.

[10]  S. Javadov,et al.  Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection. , 2004, Cardiovascular research.

[11]  J. Martinou,et al.  Role of mitochondrial membrane permeabilization in apoptosis and cancer , 2004, Oncogene.

[12]  P. Bernardi,et al.  A mitochondrial perspective on cell death. , 2001, Trends in biochemical sciences.