Tyrphostin reduces the organ injury in haemorrhagic shock: role of inducible nitric oxide synthase.

[1]  V. Castranova,et al.  Time course for inhibition of lipopolysaccharide-induced lung injury by genistein: Relationship to alteration in nuclear factor-&kgr;B activity and inflammatory agents* , 2003, Critical care medicine.

[2]  C. Thiemermann.  Protein tyrosine kinase inhibitors as novel therapeutics for systemic inflammation, shock, and organ injury. , 2003, Critical care medicine.

[3]  M. Fatehi,et al.  The Beneficial Effects of Protein Tyrosine Kinase Inhibition on the Circulatory Failure Induced by Endotoxin in the Rat , 2002, Shock.

[4]  D. Tweardy,et al.  A Nitric Oxide Scavenger Protects Against Pulmonary Inflammation Following Hemorrhagic Shock , 2002, Shock.

[5]  Simon C Watkins,et al.  The Modulation of Hepatic Injury and Heat Shock Expression by Inhibition of Inducible Nitric Oxide Synthase After Hemorrhagic Shock , 2002, Shock.

[6]  S. Harwood,et al.  Calpain inhibitor I reduces the activation of nuclear factor-k B and organ injury / dysfunction in hemorrhagic shock , 2000 .

[7]  E. Mazzon,et al.  The Tyrosine Kinase Inhibitor Tyrphostin AG 126 Reduces the Development of Colitis in the Rat , 2000, Laboratory Investigation.

[8]  I. Chaudry,et al.  Inhibition of tyrosine kinase signaling after trauma-hemorrhage: a novel approach for improving organ function and decreasing susceptibility to subsequent sepsis. , 2000, Annals of surgery.

[9]  Simon C Watkins,et al.  A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock. , 1999, The American journal of physiology.

[10]  P. Hake,et al.  Beneficial effects of mercaptoethylguanidine, an inhibitor of the inducible isoform of nitric oxide synthase and a scavenger of peroxynitrite, in a porcine model of delayed hemorrhagic shock. , 1999, Critical care medicine.

[11]  C. Thiemermann,et al.  SELECTIVE INHIBITION OF THE ACTIVITY OF INDUCIBLE NITRIC OXIDE SYNTHASE PREVENTS THE CIRCULATORY FAILURE, BUT NOT THE ORGAN INJURY/DYSFUNCTION, CAUSED BY ENDOTOXIN , 1998, Shock.

[12]  I. Chaudry,et al.  Gut and liver: the organs responsible for increased nitric oxide production after trauma-hemorrhage and resuscitation. , 1998, Archives of surgery.

[13]  A. Peitzman,et al.  Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock , 1998, The Journal of experimental medicine.

[14]  S. Cuzzocrea,et al.  Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. , 1998, Free radical biology & medicine.

[15]  C. Thiemermann,et al.  Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase , 1997, British journal of pharmacology.

[16]  C. Natanson,et al.  Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis. , 1997, The Journal of clinical investigation.

[17]  C. Thiemermann,et al.  Analysis of the signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages , 1996, British journal of pharmacology.

[18]  C. Thiemermann,et al.  The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase , 1995, British journal of pharmacology.

[19]  M. Mcdaniel,et al.  Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism. , 1995, Endocrinology.

[20]  Simon C Watkins,et al.  Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury. , 1995, Shock.

[21]  T. Uehara,et al.  Herbimycin A suppresses NF‐κB activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells , 1995, FEBS letters.

[22]  A. Levitzki,et al.  Tyrosine kinase inhibition: an approach to drug development. , 1995, Science.

[23]  R. Plevin,et al.  Protein kinase C and tyrosine kinase pathways regulate lipopolysaccharide‐induced nitric oxide synthase activity in RAW 264.7 murine macrophages , 1995, British journal of pharmacology.

[24]  C. Thiemermann,et al.  Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells , 1994, British journal of pharmacology.

[25]  A. Levitzki,et al.  Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. , 1994, Science.

[26]  S. Kunkel,et al.  Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury. , 1993, The American journal of physiology.

[27]  J. Catravas,et al.  Tyrosine kinase inhibitors suppress endotoxin- and IL-1 beta-induced NO synthesis in aortic smooth muscle cells. , 1993, The American journal of physiology.

[28]  E. DeMaria,et al.  Interleukin-1 receptor antagonist improves survival and preserves organ adenosine-5'-triphosphate after hemorrhagic shock. , 1993, Surgery.

[29]  I. Chaudry,et al.  Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin. , 1990, Cytokine.

[30]  A. Baue.  The Multiple Organ or System Failure Syndrome , 1993 .

[31]  C. Thiemermann,et al.  Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[32]  H. Redl,et al.  Pathophysiology of Shock, Sepsis, and Organ Failure , 1993, Springer Berlin Heidelberg.

[33]  K. Gersonde,et al.  Formation of free radicals and nitric oxide derivative of hemoglobin in rats during shock syndrome. , 1990, Free radical research communications.