The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients.

[1]  G. Hard,et al.  Recommendations for the Interpretation of Renal Tubule Proliferative Lesions Occurring in Rat Kidneys with Advanced Chronic Progressive Nephropathy (CPN) , 2005, Toxicologic pathology.

[2]  G. Hard,et al.  Invited Review: A Contemporary Overview of Chronic Progressive Nephropathy in the Laboratory Rat, and Its Significance for Human Risk Assessment , 2004, Toxicologic pathology.

[3]  E. Lock,et al.  Chemically Induced Renal Tubule Tumors in the Laboratory Rat and Mouse: Review of the NCI/NTP Database and Categorization of Renal Carcinogens Based on Mechanistic Information , 2004, Critical reviews in toxicology.

[4]  J. Haseman,et al.  Effect of Diet and Animal Care/Housing Protocols on Body Weight, Survival, Tumor Incidences, and Nephropathy Severity of F344 Rats in Chronic Studies , 2003, Toxicologic pathology.

[5]  R. Kapp,et al.  A combined repeated dose toxicity study and reproduction/developmental screening study in Sprague-Dawley rats with acetophenone , 2003 .

[6]  J. Haseman,et al.  The Effect of Chronic Progressive Nephropathy on the Incidence of Renal Tubule Cell Neoplasms in Control Male F344 Rats , 2002, Toxicologic pathology.

[7]  S. Choudhuri,et al.  Gender-specific and developmental influences on the expression of rat organic anion transporters. , 2002, The Journal of pharmacology and experimental therapeutics.

[8]  H. Endou,et al.  Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. , 2002, Journal of the American Society of Nephrology : JASN.

[9]  T. Imai,et al.  Multiplicity of carboxylesterase isozymes in mammals and humans: role in metabolic activation of prodrugs , 2001 .

[10]  K. Suzuki,et al.  Purification, molecular cloning, and functional expression of dog liver microsomal acyl-CoA hydrolase: a member of the carboxylesterase multigene family. , 2001, Archives of biochemistry and biophysics.

[11]  Y. Nakagawa,et al.  Metabolism and toxicity of benzophenone in isolated rat hepatocytes and estrogenic activity of its metabolites in MCF-7 cells. , 2000, Toxicology.

[12]  R. Chhabra.  NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9). Administered in feed to F344/N rats and B6C3F mice. , 2000, Toxicity report series.

[13]  H. Ragan,et al.  Markers of Renal Function and Injury , 1999 .

[14]  Y. Kanai,et al.  Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. , 1999, Journal of the American Society of Nephrology : JASN.

[15]  Joseph K. Haseman,et al.  Spontaneous Neoplasm Incidences in Fischer 344 Rats and B6C3F1 Mice in Two-Year Carcinogenicity Studies: A National Toxicology Program Update , 1998, Toxicologic pathology.

[16]  A. Tunek,et al.  Synthesis and enzymatic hydrolysis of esters, constituting simple models of soft drugs. , 1998, Chemical & pharmaceutical bulletin.

[17]  G. Hard,et al.  Mechanisms of Chemically Induced Renal Carcinogenesis in the Laboratory Rodent , 1998, Toxicologic pathology.

[18]  I. Sipes,et al.  Absorption, disposition, and metabolism of trans-methyl styryl ketone in female B6C3F1 mice. , 1997, Drug metabolism and disposition: the biological fate of chemicals.

[19]  I. Sipes,et al.  Oral and topical absorption, disposition kinetics, and the metabolic fate of trans-methyl styryl ketone in the male Fischer 344 rat. , 1997, Drug metabolism and disposition: the biological fate of chemicals.

[20]  J. Haseman,et al.  The Utility of Multiple-Section Sampling in the Histopathological Evaluation of the Kidney for Carcinogenicity Studies , 1994, Toxicologic pathology.

[21]  J. R. Mellado,et al.  A contribution to the study of the structure-mutagenicity relationship for α-dicarbonyl compounds using the Ames test , 1992 .

[22]  H. Fujita,et al.  Mutagenicity test of food additives with Salmonella typhimurium TA97 and TA102 (V) , 1990 .

[23]  G. Burdock,et al.  Acute Oral Toxicity (LD50) Study in the Rat with 3-Methyl-4-Phenyl-3-Buten-2-One , 1990 .

[24]  Y. Odagiri,et al.  Negative micronucleus tests on caprolactam and benzoin in ICR/JCL male mice. , 1989, Mutation research.

[25]  K. W. Lowe,et al.  Caprolactam and benzoin: tests for induction of chromosome aberrations and SCEs in mouse bone marrow. , 1989, Mutation research.

[26]  T. Sheldon.  An evaluation of caprolactam and benzoin in the mouse micronucleus test. , 1989, Mutation research.

[27]  T. Smith-Oliver,et al.  The induction of DNA-strand breaks and unscheduled DNA synthesis in F-344 rat hepatocytes following in vivo administration of caprolactam or benzoin. , 1989, Mutation research.

[28]  H. Bundgaard,et al.  Prodrugs as drug delivery systems. 68. Chemical and plasma-catalyzed hydrolysis of various esters of benzoic acid: a reference system for designing prodrug esters of carboxylic acid agents , 1987 .

[29]  J. Stofberg,et al.  The consumption ratio of flavouring materials: a mechanism for setting priorities for safety evaluation. , 1985, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[30]  E Gocke,et al.  Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests. , 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[31]  H. Bundgaard,et al.  Prodrugs as drug delivery systems XXV: Hydrolysis of oxazolidines--a potential new prodrug type. , 1983, Journal of pharmaceutical sciences.

[32]  I. Gaunt,et al.  Short-term-toxicity of 4-methyl-1-phenylpentan-2-ol in rats. , 1983, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[33]  F. Pasutto,et al.  Stereospecific metabolic reduction of ketones. , 1982, Journal of pharmaceutical sciences.

[34]  G. Jones,et al.  The effects of cofactor and species differences on the in vitro metabolism of propiophenone and phenylacetone. , 1981, Canadian journal of physiology and pharmacology.

[35]  R. Mcmahon,et al.  Assay of 855 test chemicals in ten tester strains using a new modification of the Ames test for bacterial mutagens. , 1979, Cancer research.

[36]  L. Caprino,et al.  Toxicological studies of photosensitizer agents and photodegradable polyolefins. , 1976, European journal of toxicology and environmental hygiene. Journal europeen de toxicologie.

[37]  M. W. Anders,et al.  Effect of phenobarbital treatment of the sterochemistry of the in vitro metabolism of ethylbenzene. , 1973, Journal of medicinal chemistry.

[38]  R. P. Hopkins,et al.  Dehydrogenation of Methylphenylcarbinol (1-Phenylethanol) by Soluble Preparations of Rat Liver , 1973 .

[39]  R. P. Hopkins,et al.  Dehydrogenation of DL-methylphenylcarbinol in the rat. , 1972, The Biochemical journal.

[40]  J. Posternak,et al.  Summaries of toxicological data: Toxicological tests on flavouring matters , 1969 .

[41]  C. P. Carpenter,et al.  An exploration of joint toxic action: twenty-seven industrial chemicals intubated in rats in all possible pairs. , 1969, Toxicology and applied pharmacology.

[42]  R. Mcmahon,et al.  Reductase for aromatic aldehydes and ketones. The partial purification and properties of a reduced triphosphopyridine nucleotide-dependent reductase from rabbit kidney cortex. , 1968, The Journal of biological chemistry.

[43]  F. Pacchiano,et al.  [Choleretic activity of cyclohexanone-2-benzyl-2-propionic acid]. , 1966, Archives internationales de pharmacodynamie et de therapie.

[44]  P. Rohrbach,et al.  [Pharmacological study of synthetic choleretics. II. Effect on the composition of the bile. III. Toxicity]. , 1958, Archives internationales de pharmacodynamie et de therapie.

[45]  D. Robinson.  Studies in detoxication. 74. The metabolism of benzhydrol, benzophenone and p-hydroxybenzophenone. , 1958, The Biochemical journal.

[46]  R. T. Williams,et al.  Studies in detoxication. 69. The metabolism of alkylbenzenes: n-propylbenzene and n-butylbenzene with further observations on ethylbenzene. , 1956, The Biochemical journal.

[47]  R. Dreisbach,et al.  Anticonvulsant properties of certain secondary and tertiary alcohols. , 1955, The Journal of pharmacology and experimental therapeutics.

[48]  R. T. Williams,et al.  Studies in detoxication. 56. The metabolism of alkylbenzenes: stereochemical aspects of the biological hydroxylation of ethylbenzene to methylphenylcarbinol. , 1954, The Biochemical journal.

[49]  A. Quick.  QUANTITATIVE STUDIES OF β-OXIDATION II. THE METABOLISM OF PHENYLVALERIC ACID, PHENYL-α, β-PENTENIC ACID, PHENYL-β, γ-PENTENIC ACID, MANDELIC ACID, PHENYL-β-HYDROXYPROPIONIC ACID, AND ACETOPHENONE IN DOGS , 1928 .

[50]  R. T. Williams,et al.  Studies in Detoxication , 2005 .

[51]  J. Smith,et al.  Studies in Detoxication , 2005 .

[52]  S. Matsumoto,et al.  Partial outlet obstruction of the rat bladder induces a stimulatory response on proliferation of the bladder smooth muscle cells , 2004, International Urology and Nephrology.

[53]  G. Boorman,et al.  C-Cell Hyperplasia, C-Cell Adenoma, and C-Cell Carcinoma, Thyroid, Rat , 1996 .

[54]  M. Shelby,et al.  Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals , 1993, Environmental and molecular mutagenesis.

[55]  K. M. Reisterer,et al.  Mapping protein foulants on polysulfone membranes using microspectrophotometry : measuring adsorption spectra in reflective mode provides fast and easy determination of the extent of protein fouling on ultrafiltration membranes , 1993 .

[56]  H. Fujita.  Mutagenecity test of food additives with Salmonella typhimurium TA97 and TA102. , 1993 .

[57]  G. Burdock,et al.  Safety evaluation of benzophenone. , 1991, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[58]  I. C. Munro,et al.  Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment. 15. GRAS substances. , 1990 .

[59]  P. Working.  Assessment of unscheduled DNA synthesis in Fischer 344 rat pachytene spermatocytes exposed to caprolactam or benzoin in vivo. , 1989, Mutation research.

[60]  M. Shelby,et al.  Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro III: Results with 27 chemicals , 1989, Environmental and molecular mutagenesis.

[61]  F. Quimby,et al.  The Clinical chemistry of laboratory animals , 1989 .

[62]  E. Zeiger,et al.  Chromosome aberration and sister chromatid exchange tests in chinese hamster ovary cells in vitro: II. Results with 20 chemicals , 1989, Environmental and molecular mutagenesis.

[63]  E. Zeiger,et al.  Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. , 1987, Environmental mutagenesis.

[64]  G A Boorman,et al.  Liver lesions in B6C3F1 mice: the National Toxicology Program, experience and position. , 1987, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

[65]  L. Unger.  The Worldwide flavor and fragrance industry, 1985-1990 , 1987 .

[66]  D. Brusick.  Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations. , 1986, Environmental mutagenesis.

[67]  E. Zeiger,et al.  Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. , 1986, Environmental mutagenesis.

[68]  W A Bowles,et al.  Acute oral toxicity and repellency of 933 chemicals to house and deer mice , 1985, Archives of environmental contamination and toxicology.

[69]  T. Sofuni,et al.  [Mutagenicity tests on organic chemical contaminants in city water and related compounds. II. Chromosome aberration tests in cultured mammalian cells]. , 1985, Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences.

[70]  M. Ishidate,et al.  [Mutagenicity tests on organic chemical contaminants in city water and related compounds. I. Bacterial mutagenicity tests]. , 1985, Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences.

[71]  M. Prival,et al.  Evaluation, using Salmonella typhimurium, of the mutagenicity of seven chemicals found in cosmetics. , 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[72]  H. Kitagawa.  Acute toxicity study in rats and rabbits treated with polyoxyethylene nonylphenyl etherfilm (ST-film) , 1981 .

[73]  J. Ashby,et al.  Evaluation of short-term tests for carcinogens : report of the international collaborative program , 1981 .

[74]  E. Heymann,et al.  Chapter 16 – Carboxylesterases and Amidases , 1980 .

[75]  I. Florin,et al.  Screening of tobacco smoke constituents for mutagenicity using the Ames' test. , 1980, Toxicology.

[76]  D. Finco.  9 – Kidney Function , 1980 .

[77]  William B. Jakoby,et al.  Enzymatic basis of detoxication , 1980 .

[78]  R. Mcmahon,et al.  Reaction pathways of in vivo stereoselective conversion of ethylbenzene to (-)-mandelic acid. , 1976, Xenobiotica; the fate of foreign compounds in biological systems.

[79]  A. Lansdown,et al.  Short-term toxicity of methylphenylcarbinyl acetate in rats. , 1974, Food and cosmetics toxicology.

[80]  W. Lenk,et al.  Hydroxyacetophenones: urinary metabolites of ethylbenzene and acetophenone in the rabbit. , 1974, Xenobiotica; the fate of foreign compounds in biological systems.

[81]  K. Leibman.  Reduction of ketones in liver cytosol. , 1971, Xenobiotica; the fate of foreign compounds in biological systems.

[82]  B. L. Oser,et al.  Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment. 4. gRAS (generally recognized as safe) substances , 1970 .

[83]  A. A. Nelson,et al.  Food flavourings and compounds of related structure. II. Subacute and chronic toxicity. , 1967, Food and cosmetics toxicology.

[84]  Rolf Schock,et al.  On induction , 1965, Notre Dame J. Formal Log..

[85]  S. Carson,et al.  Toxicological tests on flavouring matters. , 1965, Food and cosmetics toxicology.

[86]  Jean M. Taylor,et al.  Food flavourings and compounds of related structure I. Acute oral toxicity , 1964 .

[87]  J. Kaneko.  Clinical biochemistry of domestic animals , 1963 .

[88]  C. P. Carpenter,et al.  Range-finding toxicity data: List VI. , 1962, American Industrial Hygiene Association journal.

[89]  D. Mertz,et al.  [Studies on the choleretic action of 1-phenylpropanol]. , 1956, Deutsche medizinische Wochenschrift.

[90]  C. P. Carpenter,et al.  Further experience with the range finding test in the industrial toxicology laboratory. , 1948, The Journal of industrial hygiene and toxicology.

[91]  Smyth Hf,et al.  Further experience with the range finding test in the industrial toxicology laboratory. , 1948 .

[92]  H. Thierfelder,et al.  Zur Kenntnis des Verhaltens fettaromatischer Ketone im Tierkörper. , 1923 .