CHANGES IN IMMUNOLOCALISATION WITH AGE AND POSSIBLE ROLES FROM PROLIFERATION TO APOPTOSIS

T. Aizawa, MD, PhD, LecturerS. Kokubun, MD, PhD, Professor and ChairmanT. Kawamata, MD, Medical StaffY. Tanaka, MD, PhD, University LecturerDepartment of Orthopaedic Surgery, Tohoku University School of Medi-cine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Japan 980-8574.H. I. Roach, PhD, University LecturerGeneral Hospital, Tremona Road, Southampton SO16 6YD, UK.Correspondence should be sent to Dr T. Aizawa.©1999 British Editorial Society of Bone and Joint Surgery0301-620X/99/59492 $2.00

[1]  H. Roach,et al.  Changes in the expression of Fas, osteonectin and osteocalcin with age in the rabbit growth plate. , 1998, The Journal of bone and joint surgery. British volume.

[2]  S. Kokubun,et al.  Apoptosis and proliferation of growth plate chondrocytes in rabbits. , 1997, The Journal of bone and joint surgery. British volume.

[3]  M. Hauchecorne,et al.  Expression and subcellular localization of the Myc superfamily proteins: c-Myc, Max, Mad1 and Mxi1 in the epiphyseal plate cartilage chondrocytes of growing rats. , 1997, Cellular and molecular biology.

[4]  Y. Sasaguri,et al.  MORPHOLOGICAL AND BIOCHEMICAL EVIDENCE FOR APOPTOSIS IN THE TERMINAL HYPERTROPHIC CHONDROCYTES OF THE GROWTH PLATE , 1996, The Journal of pathology.

[5]  R. Johnston,et al.  Apoptosis induced by c-myc overexpression is dependent on growth conditions. , 1995, Experimental cell research.

[6]  C. Papadimitriou,et al.  Immunohistochemical detection of the c-myc oncogene product in normal, hyperplastic and carcinomatous endometrium. , 1994, Oncology.

[7]  G. Evan,et al.  c‐Myc‐induced apoptosis in fibroblasts is inhibited by specific cytokines. , 1994, The EMBO journal.

[8]  J. Hesketh,et al.  The control of chondrocyte differentiation during endochondral bone growth in vivo: changes in TGF-beta and the proto-oncogene c-myc. , 1993, Journal of cell science.

[9]  C. Petropoulos,et al.  Expression and role of c-myc in chondrocytes undergoing endochondral ossification. , 1993, The Journal of biological chemistry.

[10]  M. Eilers,et al.  The functions of Myc proteins. , 1992, Biochimica et biophysica acta.

[11]  S. Ben‐Sasson,et al.  Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation , 1992, The Journal of cell biology.

[12]  M. Silbermann,et al.  Chondroclasts and endothelial cells collaborate in the process of cartilage resorption , 1992, The Anatomical record.

[13]  J. Hesketh,et al.  The proto‐oncogene C‐myc is involved in cell differentiation as well as cell proliferation: Studies on growth plate chondrocytes in situ , 1992, Journal of cellular physiology.

[14]  Gerard I. Evan,et al.  Induction of apoptosis in fibroblasts by c-myc protein , 1992, Cell.

[15]  J. Cleveland,et al.  Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. , 1991, Oncogene.

[16]  W. Robertson.  Newest knowledge of the growth plate. , 1990, Clinical orthopaedics and related research.

[17]  C. Farnum,et al.  Cellular turnover at the chondro‐osseous junction of growth plate cartilage: Analysis by serial sections at the light microscopical level , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[18]  K. Aozasa,et al.  Prognostic significance of Ki‐67 reactivity in soft tissue sarcomas , 1989, Cancer.

[19]  H Stein,et al.  Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). , 1984, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[20]  G. Evan,et al.  Apoptosis and the cell cycle. , 1995, Current opinion in cell biology.

[21]  R. Cancedda,et al.  Constitutive myc expression impairs hypertrophy and calcification in cartilage. , 1992, Developmental biology.

[22]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.