A luminescent Zn(II) coordination polymer for selective detection of Fe3+ ion that reverses the resistance of ovarian cancer to cisplatin

By using the π-electron-rich organic ligand biphenyl-3,4′,5-tricarboxylic acid (H3BPT), the three-dimensional coordination polymer [Zn4(μ4-H2O)Cl2(BPT)2](DMF)2 was successfully prepared by the reaction of H3BPT and Zn(NO3)2·6H2O in the presence of HCl as the pH modulator under solvothermal conditions. The sensing as well as fluorescence properties of the coordination polymer were studied in detail, showing the selective quenching response that was highly efficient for the Fe3+ ion. In the activity research section, we firstly evaluate the promotion effects of the compound on the efficacy of cisplatin against HO-8910/DDP cancer cells with CCK-8 assay, as well as the IC50 calculation. Next, to explore the relative mechanism, the reverse transcription polymerase chain reaction was performed and the mdr1 and mdr3 genes relative expression was measured. The results obtained through molecular docking and pose scoring software exhibited a possible binding mode of the compound binding to Bcl2, which might provide potential regulation mechanisms for the compound.

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