Structural Polymorphism and Diversifying Selection on the Pregnancy Malaria Vaccine Candidate Var2csa

[1]  F. Ayala,et al.  Evolutionary origin of Plasmodium and other Apicomplexa based on rRNA genes. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[2]  F J Ayala,et al.  Evolutionary origin of human and primate malarias: evidence from the circumsporozoite protein gene. , 1995, Molecular biology and evolution.

[3]  Thomas G. Dietterich What is machine learning? , 2020, Archives of Disease in Childhood.

[4]  Patrick E. Duffy,et al.  Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta , 1996, Science.

[5]  R. Samudrala,et al.  An all-atom distance-dependent conditional probability discriminatory function for protein structure prediction. , 1998, Journal of molecular biology.

[6]  François Nosten,et al.  Maternal antibodies block malaria , 1998, Nature.

[7]  R Samudrala,et al.  A graph-theoretic algorithm for comparative modeling of protein structure. , 1998, Journal of molecular biology.

[8]  M. Molyneux,et al.  Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties. , 1999, The Journal of infectious diseases.

[9]  M. Dorris,et al.  Analysis of Plasmodium falciparum PfEMP-1/var genes suggests that recombination rearranges constrained sequences. , 1999, Molecular and biochemical parasitology.

[10]  B. Gamain,et al.  Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family. , 2000, Molecular and biochemical parasitology.

[11]  John C. Wootton,et al.  Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum , 2002, Nature.

[12]  W. S. Valdar,et al.  Scoring residue conservation , 2002, Proteins.

[13]  M. Levitt,et al.  A comprehensive analysis of 40 blind protein structure predictions , 2002, BMC Structural Biology.

[14]  Ogobara K. Doumbo,et al.  The pathogenic basis of malaria , 2002, Nature.

[15]  Joseph D. Smith,et al.  Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene family , 2003, Molecular microbiology.

[16]  M. Fried,et al.  Antibodies That Inhibit Plasmodium falciparum Adhesion to Chondroitin Sulfate A Are Associated with Increased Birth Weight and the Gestational Age of Newborns , 2003, Infection and Immunity.

[17]  Ram Samudrala,et al.  PROTINFO: secondary and tertiary protein structure prediction , 2003, Nucleic Acids Res..

[18]  P. Awadalla The evolutionary genomics of pathogen recombination , 2003, Nature Reviews Genetics.

[19]  Thomas Lavstsen,et al.  Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A‐adhering Plasmodium falciparum involved in pregnancy‐associated malaria , 2003, Molecular microbiology.

[20]  Thor G. Theander,et al.  Evidence for the Involvement of VAR2CSA in Pregnancy-associated Malaria , 2004, The Journal of experimental medicine.

[21]  Joseph D. Smith,et al.  Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines , 2004, The Journal of experimental medicine.

[22]  E. J. Mann,et al.  Antibodies to variant surface antigens of Plasmodium falciparum-infected erythrocytes and adhesion inhibitory antibodies are associated with placental malaria and have overlapping and distinct targets. , 2004, The Journal of infectious diseases.

[23]  P. Deloron,et al.  Variable adhesion abilities and overlapping antigenic properties in placental Plasmodium falciparum isolates. , 2004, The Journal of infectious diseases.

[24]  C. Menéndez,et al.  The sick placenta-the role of malaria. , 2004, Placenta.

[25]  Kevin Marsh,et al.  Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria , 2004, The Lancet.

[26]  E. J. Mann,et al.  Cross-Reactive Surface Epitopes on Chondroitin Sulfate A-Adherent Plasmodium falciparum-Infected Erythrocytes Are Associated with Transcription of var2csa , 2005, Infection and Immunity.

[27]  B. Gamain,et al.  Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites. , 2005, The Journal of infectious diseases.

[28]  T. Theander,et al.  High level of var2csa transcription by Plasmodium falciparum isolated from the placenta. , 2005, The Journal of infectious diseases.

[29]  Leemor Joshua-Tor,et al.  Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum , 2005, Cell.

[30]  Michael Lanzer,et al.  A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A , 2005, EMBO reports.

[31]  Shing-Chung Ngan,et al.  PROTINFO: new algorithms for enhanced protein structure predictions , 2005, Nucleic Acids Res..

[32]  Ram Samudrala,et al.  Disguising itself--insights into Plasmodium falciparum binding and immune evasion from the DBL crystal structure. , 2006, Molecular and biochemical parasitology.

[33]  Ole Lund,et al.  Epitope Mapping and Topographic Analysis of VAR2CSA DBL3X Involved in P. falciparum Placental Sequestration , 2006, PLoS pathogens.

[34]  M. Frank,et al.  Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum. , 2006, International journal for parasitology.

[35]  M. Molyneux,et al.  Transcribed var Genes Associated with Placental Malaria in MalawianWomen , 2006, Infection and Immunity.

[36]  E. J. Mann,et al.  Antigenic differences and conservation among placental Plasmodium falciparum-infected erythrocytes and acquisition of variant-specific and cross-reactive antibodies. , 2006, The Journal of infectious diseases.

[37]  T. Theander,et al.  Dynamics of anti-VAR2CSA immunoglobulin G response in a cohort of senegalese pregnant women. , 2006, The Journal of infectious diseases.

[38]  Daniel J. Wilson,et al.  Estimating Diversifying Selection and Functional Constraint in the Presence of Recombination , 2006, Genetics.

[39]  David Posada,et al.  Automated phylogenetic detection of recombination using a genetic algorithm. , 2006, Molecular biology and evolution.

[40]  Hassan Belrhali,et al.  Structural basis for Duffy recognition by the malaria parasite Duffy-binding-like domain , 2006, Nature.

[41]  Philip Awadalla,et al.  Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria. , 2006, Molecular and biochemical parasitology.

[42]  Stephen J Rogerson,et al.  VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum. , 2006, Molecular and biochemical parasitology.

[43]  P. Andersen,et al.  Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA , 2007, Molecular microbiology.

[44]  Nebojsa Jojic,et al.  Discovering Patterns in Biological Sequences by Optimal Segmentation , 2007, UAI.