Nkx2-5 Pathways and Congenital Heart Disease Loss of Ventricular Myocyte Lineage Specification Leads to Progressive Cardiomyopathy and Complete Heart Block

[1]  Robert E. Poelmann,et al.  Cardiac Development , 2008, Progress in Experimental Cardiology.

[2]  Michael D. Schneider,et al.  BMP10 is essential for maintaining cardiac growth during murine cardiogenesis , 2004, Development.

[3]  Robert P. Thompson,et al.  Spatiotemporal pattern of commitment to slowed proliferation in the embryonic mouse heart indicates progressive differentiation of the cardiac conduction system. , 2003, Anatomical Record Part A-discoveries in Molecular Cellular and Evolutionary Biology.

[4]  Jonathan C. Cohen,et al.  GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5 , 2003, Nature.

[5]  D. Elliott,et al.  Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. , 2003, Journal of the American College of Cardiology.

[6]  D. Roden,et al.  Development of the Cardiac Conduction System as Delineated by minK‐lacZ , 2003, Journal of cardiovascular electrophysiology.

[7]  Y. Ishikawa,et al.  Atrial Chamber-specific Expression of Sarcolipin Is Regulated during Development and Hypertrophic Remodeling* , 2003, The Journal of Biological Chemistry.

[8]  E. Azene,et al.  Molecular Basis of the Effect of Potassium on Heterologously Expressed Pacemaker (HCN) Channels , 2003, The Journal of physiology.

[9]  S. Nattel,et al.  Comparison of Ion-Channel Subunit Expression in Canine Cardiac Purkinje Fibers and Ventricular Muscle , 2002, Circulation research.

[10]  Thomas M. Harris,et al.  Modulation of Cardiac Growth and Development by HOP, an Unusual Homeodomain Protein , 2002, Cell.

[11]  R. Schwartz,et al.  Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development , 2002, Cell.

[12]  S. Rivkees,et al.  Neuregulin-1 promotes formation of the murine cardiac conduction system , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Martin Biel,et al.  Cardiac HCN channels: structure, function, and modulation. , 2002, Trends in cardiovascular medicine.

[14]  K. Devriendt,et al.  Progressive AV‐block and anomalous venous return among cardiac anomalies associated with two novel missense mutations in the CSX/NKX2‐5 Gene , 2002, Human mutation.

[15]  E. Goldmuntz,et al.  NKX2.5 mutations in patients with tetralogy of fallot. , 2002 .

[16]  B. Bruneau Transcriptional Regulation of Vertebrate Cardiac Morphogenesis , 2002, Circulation research.

[17]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[18]  P. Kaufmann,et al.  Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy , 2001, Heart.

[19]  S. Ho,et al.  Anatomic Criteria for Identifying the Components of the Axis Responsible for Atrioventricular Conduction , 2001, Journal of cardiovascular electrophysiology.

[20]  J. Epstein,et al.  Developing models of DiGeorge syndrome. , 2001, Trends in genetics : TIG.

[21]  J. Schmitt,et al.  A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease , 2001, Cell.

[22]  M. Yacoub,et al.  Elevated expression of Nkx‐2.5 in developing myocardial conduction cells , 2001, The Anatomical record.

[23]  D. Franco,et al.  Molecular characterization of the ventricular conduction system in the developing mouse heart: topographical correlation in normal and congenitally malformed hearts. , 2001, Cardiovascular research.

[24]  David A. Williams,et al.  Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. , 2000, Blood.

[25]  A. B. Brown,et al.  A Novel Genetic Pathway for Sudden Cardiac Death via Defects in the Transition between Ventricular and Conduction System Cell Lineages , 2000, Cell.

[26]  J. Murray,et al.  Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. , 2000, Developmental biology.

[27]  Robert H. Anderson,et al.  How Constant Anatomically is the Tendon of Todaro as a Marker for the Triangle of Koch? , 2000, Journal of cardiovascular electrophysiology.

[28]  J. Seidman,et al.  Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. , 1999, The Journal of clinical investigation.

[29]  M. Sheppard,et al.  Localisation and quantitation of autonomic innervation in the porcine heart II: endocardium, myocardium and epicardium , 1999, Journal of anatomy.

[30]  M. Sheppard,et al.  Localisation and quantitation of autonomic innervation in the porcine heart I: conduction system , 1999, Journal of anatomy.

[31]  R. Pauli,et al.  Ventricular noncompaction and distal chromosome 5q deletion. , 1999, American journal of medical genetics.

[32]  J. Ross,et al.  Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress , 1999, Cell.

[33]  S. Izumo,et al.  The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. , 1999, Development.

[34]  D. Roden,et al.  Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. , 1999, Circulation research.

[35]  V. Rosen,et al.  Heart specific expression of mouse BMP-10 a novel member of the TGF-β superfamily , 1999, Mechanisms of Development.

[36]  J. Seidman,et al.  Congenital heart disease caused by mutations in the transcription factor NKX2-5. , 1998, Science.

[37]  K. Chien,et al.  Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. , 1998, Development.

[38]  Kuo-Fen Lee,et al.  Requirement for neuregulin receptor erbB2 in neural and cardiac development , 1995, Nature.

[39]  Rüdiger Klein,et al.  Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor , 1995, Nature.

[40]  Ruili Li,et al.  Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. , 1995, Genes & development.

[41]  R. P. Thompson,et al.  The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. , 1993, Journal of cell science.

[42]  J. Rossant,et al.  Embryonic stem cells alone are able to support fetal development in the mouse. , 1990, Development.

[43]  Robert H. Anderson,et al.  A Combined Morphological and Electrophysiological Study of the Atrioventricular Node of the Rabbit Heart , 1974, Circulation research.

[44]  E. Schenk,et al.  HISTOCHEMICAL METHODS FOR SEPARATE, CONSECUTIVE AND SIMULTANEOUS DEMONSTRATION OF ACETYLCHOLINESTERASE AND NOREPINEPHRINE IN CRYOSTAT SECTIONS , 1967, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[45]  K. Chien,et al.  Cre-constructing the heart , 2003, Nature Genetics.

[46]  Milena B. Furtado,et al.  Homeodomain factor Nkx2-5 in heart development and disease. , 2002, Cold Spring Harbor symposia on quantitative biology.

[47]  D. Agard,et al.  Fluorescence microscopy in three dimensions. , 1989, Methods in cell biology.