Lymphatic abnormalities in the normal contralateral arms of subjects with breast cancer-related lymphedema as assessed by near-infrared fluorescent imaging

Current treatment of unilateral breast cancer-related lymphedema (BCRL) is only directed to the afflicted arm. Near-infrared fluorescent imaging (NIRF) of arm lymphatic vessel architecture and function in BCRL and control subjects revealed a trend of increased lymphatic abnormalities in both the afflicted and unafflicted arms with increasing time after lymphedema onset. These pilot results show that BCRL may progress to affect the clinically “normal” arm, and suggest that cancer-related lymphedema may become a systemic, rather than local, malady. These findings support further study to understand the etiology of cancer-related lymphedema and lead to better diagnostics and therapeutics directed to the systemic lymphatic system.

[1]  A. Cosimi,et al.  Effective treatment of lymphedema of the extremities. , 1998, Archives of surgery.

[2]  R. Barber,et al.  Local vascular access of radioprotein injected subcutaneously in healthy subjects and patients with breast cancer-related lymphedema. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  R. Barber,et al.  Variation in lymphatic function may predispose to development of breast cancer-related lymphoedema. , 2004, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[4]  G. Vlastos,et al.  Lymphedema following axillary lymph node dissection for breast cancer. , 2006, Surgical oncology.

[5]  Kazuhiko Sato.  Current technical overviews of sentinel lymph node biopsy for breast cancer , 2007, Breast cancer.

[6]  W. Svensson,et al.  Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy , 2007, The Journal of physiology.

[7]  L. Gerber,et al.  Preoperative assessment enables the early diagnosis and successful treatment of lymphedema , 2008, Cancer.

[8]  John C Rasmussen,et al.  New Horizons for Imaging Lymphatic Function , 2008, Annals of the New York Academy of Sciences.

[9]  H. Sasaki,et al.  Risk factors for lower limb lymphedema after lymph node dissection in patients with ovarian and uterine carcinoma , 2009, BMC Cancer.

[10]  J. Thomas,et al.  ILIOINGUINAL LYMPH NODE DISSECTION FOR PALPABLE METASTATIC MELANOMA TO THE GROIN , 2008, ANZ journal of surgery.

[11]  K. Byth,et al.  Defining Lower Limb Lymphedema After Inguinal or Ilio-Inguinal Dissection in Patients With Melanoma Using Classification and Regression Tree Analysis , 2008, Annals of surgery.

[12]  Joachim E. Zuther,et al.  Lymphedema Management: The Comprehensive Guide for Practitioners , 2009 .

[13]  I-Chih Tan,et al.  Lymphatic imaging in humans with near-infrared fluorescence. , 2009, Current opinion in biotechnology.

[14]  C. Tian,et al.  Radiation Therapy Compared With Pelvic Node Resection for Node-Positive Vulvar Cancer: A Randomized Controlled Trial , 2009, Obstetrics and gynecology.

[15]  M. Ross,et al.  Lymphedema beyond breast cancer , 2010, Cancer.

[16]  L. Kristjanson,et al.  Assessment of quality of life in lymphedema patients: validity and reliability of the Swedish version of the Lymphedema Quality of Life Inventory (LQOLI). , 2010, Lymphology.

[17]  J. Armer,et al.  Post-breast cancer lymphedema: incidence increases from 12 to 30 to 60 months. , 2010, Lymphology.

[18]  Eva M. Sevick-Muraca,et al.  Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema , 2010, Biomedical optics express.

[19]  P. Choyke,et al.  Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models. , 2010, Nanomedicine.

[20]  Eva M. Sevick-Muraca,et al.  Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update~!2009-12-07~!2009-12-23~!2010-05-26~! , 2010 .

[21]  I-Chih Tan,et al.  Near-Infrared Fluorescence Imaging in Humans with Indocyanine Green: A Review and Update. , 2010, Open surgical oncology journal.

[22]  A. Stejskal,et al.  Radioprotection from radiation-induced lymphedema without tumor protection. , 2010, Lymphology.

[23]  Garry Cooper,et al.  Early diagnosis of lymphoedema helps to reduce its psychological and social impact. , 2010, Nursing times.

[24]  J. Darbinian,et al.  Risk factors for lymphedema in a prospective breast cancer survivorship study: the Pathways Study. , 2010, Archives of surgery.

[25]  Jeffrey E. Lee,et al.  Prospective Assessment of Postoperative Complications and Associated Costs Following Inguinal Lymph Node Dissection (ILND) in Melanoma Patients , 2010, Annals of Surgical Oncology.

[26]  Yong Eun Chung,et al.  Feasibility of Interstitial CT Lymphography Using Optimized Iodized Oil Emulsion in Rats , 2010, Investigative radiology.

[27]  M. Kaneuchi,et al.  Risk factors for lower-limb lymphedema after surgery for cervical cancer , 2011, International Journal of Clinical Oncology.

[28]  Sunkuk Kwon,et al.  Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence. , 2010, Translational oncology.

[29]  M. Dietrich,et al.  Body mass index and breast cancer treatment-related lymphedema , 2011, Supportive Care in Cancer.

[30]  Choung-Soo Kim,et al.  Does the greater number of lymph nodes removed during standard lymph node dissection predict better patient survival following radical cystectomy? , 2011, World Journal of Urology.

[31]  Stamatakos Michael,et al.  Lymphedema and breast cancer: a review of the literature , 2011, Breast cancer.

[32]  A. Soran,et al.  Estimating the Probability of Lymphedema After Breast Cancer Surgery , 2010, American journal of clinical oncology.

[33]  I-Chih Tan,et al.  Assessment of lymphatic contractile function after manual lymphatic drainage using near-infrared fluorescence imaging. , 2011, Archives of physical medicine and rehabilitation.

[34]  E. U. Cidon,et al.  Life after Breast Cancer: Dealing with Lymphoedema , 2011, Clinical Medicine Insights. Oncology.

[35]  Charikleia Stefanaki,et al.  Erratum to: Lymphedema and breast cancer: a review of the literature , 2011 .

[36]  I. Koshima,et al.  Indocyanine Green–Enhanced Lymphography for Upper Extremity Lymphedema: A Novel Severity Staging System Using Dermal Backflow Patterns , 2011, Plastic and reconstructive surgery.

[37]  A. Giuliano,et al.  Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. , 2011, JAMA.

[38]  E M Sevick-Muraca,et al.  Translation of near-infrared fluorescence imaging technologies: emerging clinical applications. , 2012, Annual review of medicine.

[39]  P. Mortimer,et al.  Lymphatic Dysfunction in the Apparently Clinically Normal Contralateral Limbs of Patients With Unilateral Lower Limb Swelling , 2012, Clinical nuclear medicine.