Protective Effect of Indomethacin Against Exercise-Induced Injuries in Mouse Skeletal Muscle Fibers

The role of prostaglandin synthesis was evaluated by indomethacin administration in the pathogenesis of exercise-induced muscle fiber injuries in soleus and quadriceps femoris muscles of mice. The administration of indomethacin before, during, and after 9 h exertion (s.c., 6 mg/kg during and just after exertion and 1.5-3 mg/kg before exertion and later twice a day) caused a significant histologic protection against exercise injuries and considerably reduced the exercise responses of beta-glucuronidase and glucose-6-phosphate dehydrogenase activities (enzymatic indicators of necrotic lesions in skeletal muscles) on the 2nd post-exercise day. The administration of indomethacin before and during the exertion (3 and 10 mg/kg, respectively) but not after exertion caused only a slight histologic protection while the enzymatic indicators showed a nonsignificant effect.

[1]  H. Kuipers,et al.  Influence of a Prostaglandin-lnhibiting Drug on Muscle Soreness After Eccentric Work , 1985, International journal of sports medicine.

[2]  A. Salminen,et al.  Lysosomal changes in mouse skeletal muscle during the repair of exercise injuries , 1985, Muscle & nerve.

[3]  V. Vihko,et al.  Susceptibility of mouse skeletal muscles to exercise injuries , 1983, Muscle & nerve.

[4]  K. R. Mills,et al.  Ultrastructural changes after concentric and eccentric contractions of human muscle , 1983, Journal of the Neurological Sciences.

[5]  M. Sjöström,et al.  Myofibrillar Damage Following Intense Eccentric Exercise in Man , 1983, International journal of sports medicine.

[6]  P. Reeds,et al.  Protein synthesis in isolated rabbit forelimb muscles. The possible role of metabolites of arachidonic acid in the response to intermittent stretching. , 1983, The Biochemical journal.

[7]  D. Costill,et al.  Muscle fiber necrosis associated with human marathon runners , 1983, Journal of the Neurological Sciences.

[8]  E. Young,et al.  Prostaglandins and exercise hyperemia of dog skeletal muscle. , 1980, The American journal of physiology.

[9]  A. Hargens,et al.  Acute exertional superficial posterior compartment syndrome , 1978, The American journal of sports medicine.

[10]  E. Young,et al.  Prostaglandin and histaminergic mediation of prolonged vasodilation after exercise. , 1977, The American journal of physiology.

[11]  D. Tompkins,et al.  Exercise myopathy of the extensor carpi ulnaris muscle. Report of a case. , 1977, The Journal of bone and joint surgery. American volume.

[12]  K. Herbaczyńska-Cedro,et al.  Muscular work and the release of prostaglandin-like substances. , 1976, Cardiovascular research.

[13]  Å. Kilbom,et al.  Endogenous prostaglandins as local regulators of blood flow in man: effect of indomethacin on reactive and functional hyperaemia. , 1976, The Journal of physiology.

[14]  J. Vane,et al.  Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation , 1973, Nature.

[15]  G. Omer.  The Anterior And The Lateral Compartment Syndrome Of The Leg , 1970 .

[16]  J. Greenberg,et al.  Exertional rhabdomyolysis with myoglobinuria in a large group of military trainees , 1967, Neurology.

[17]  V. Vihko,et al.  Autophagic response to strenuous exercise in mouse skeletal muscle fibers , 1984, Virchows Archiv. B, Cell pathology including molecular pathology.

[18]  F. Carey,et al.  Alternative pathways of arachidonate metabolism: prostaglandins, thromboxane and leukotrienes. , 1983, Essays in biochemistry.

[19]  J. Nowak.  Prostaglandins in the cardiovascular system in man. A biochemical and physiological study. , 1979, Acta physiologica Scandinavica. Supplementum.

[20]  G. Majno,et al.  Acute inflammation. A review. , 1977, The American journal of pathology.

[21]  J. Blandy,et al.  Ischaemic Myositis of the Leg Muscles from Exercise , 1957 .