Effects of propofol on cerebral blood flow and the metabolic rate of oxygen in humans

Background: Effects of propofol on human cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), and blood flow‐metabolism coupling have not been fully evaluated. We therefore assessed the effects of propofol on total‐CBF and CMRO2 in patients without noxious stimuli and neurologic disorders.

[1]  H. Sonntag,et al.  [Effect of Disoprivan (propofol) on the circulation and oxygen consumption of the brain and CO2 reactivity of brain vessels in the human]. , 1987, Der Anaesthesist.

[2]  D. Prough,et al.  Phenylephrine does not reduce cerebral perfusion during canine cardiopulmonary bypass. , 1994, Anesthesia and analgesia.

[3]  A. Gelb,et al.  The responsiveness of cerebral blood flow to changes in arterial carbon dioxide is maintained during propofol-nitrous oxide anesthesia in humans. , 1992, Anesthesiology.

[4]  C. Plets,et al.  Effect of Propofol on Cerebral Circulation and Autoregulation in the Baboon , 1990, Anesthesia and analgesia.

[5]  S. Kety,et al.  THE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN BY THE USE OF NITROUS OXIDE IN LOW CONCENTRATIONS , 1945 .

[6]  T. Orszulak,et al.  Nitrous oxide method of measuring cerebral blood flow during hypothermic cardiopulmonary bypass. , 1997, The Annals of thoracic surgery.

[7]  A. Smith,et al.  Cerebral Blood Flow and Metabolism: Effects of Anesthetic Drugs and Techniques , 1972, Anesthesiology.

[8]  L. F. Nims,et al.  ARTERIAL AND CEREBRAL VENOUS BLOOD ARTERIAL-VENOUS DIFFERENCES IN MAN , 1942 .

[9]  H. Toda,et al.  Direct vasoconstrictor and vasodilator effects of propofol in isolated dog arteries. , 1992, British journal of anaesthesia.

[10]  Mikael Elam,et al.  The Effects of Propofol on Cerebral Blood Flow Velocity and Cerebral Oxygen Extraction During Cardiopulmonary Bypass , 1998, Anesthesia and analgesia.

[11]  M. Todd,et al.  A dose-response study of the influence of propofol on cerebral blood flow, metabolism and the electroencephalogram in the rabbit. , 1992, Journal of neurosurgical anesthesiology.

[12]  M. Pinaud,et al.  Effects of Propofol on Cerebral Hemodynamics and Metabolism in Patients with Brain Trauma , 1988 .

[13]  A. Vandesteene,et al.  Effect of propofol on cerebral blood flow and metabolism in man , 1988, Anaesthesia.

[14]  H. Fukuyama,et al.  Cerebral blood flow and metabolism in multiple system atrophy of the Shy-Drager syndrome type: A PET study , 1998, Journal of Neurological Sciences.

[15]  W. White,et al.  Cerebral Physiologic Effects of Burst Suppression Doses of Propofol During Nonpulsatile Cardiopulmonary Bypass , 1995, Anesthesia and analgesia.

[16]  A. Lam,et al.  Graded Hypercapnia and Cerebral Autoregulation during Sevoflurane or Propofol Anesthesia , 2000, Anesthesiology.

[17]  E. Mackenzie,et al.  Cerebral Blood Flow and Metabolism , 1993 .

[18]  S. Strebel,et al.  The Impact of Systemic Vasoconstrictors on the Cerebral Circulation of Anesthetized Patients , 1998, Anesthesiology.

[19]  P. Hartvig,et al.  Cerebral normoxia in the rhesus monkey during isofluraneor propofol‐induced hypotension and hypocapnia, despite disparate blood‐flow patterns , 1997, Acta anaesthesiologica Scandinavica.

[20]  K. Shingu,et al.  Comparison of CNS effects of propofol and thiopentone in cats. , 1993, British journal of anaesthesia.

[21]  F Henry-Le Bros,et al.  Cerebral blood flow and metabolism, L Edvinsson, E Mackenzie, J McCulloch. Raven Press, Paris (1993) , 1994 .

[22]  Alan C. Evans,et al.  Brain Mechanisms of Propofol-Induced Loss of Consciousness in Humans: a Positron Emission Tomographic Study , 1999, The Journal of Neuroscience.

[23]  T. Sakabe,et al.  Cerebral Effects of Nitrous Oxide in the Dog , 1978, Anesthesiology.

[24]  R. Anderson,et al.  Cerebral blood flow during cardiac operations: comparison of Kety-Schmidt and xenon-133 clearance methods. , 1995, The Annals of thoracic surgery.

[25]  B. Schorn,et al.  Flow Velocity Measurements as an Index of Cerebral Blood Flow: Validity of Transcranial Doppler Sonographic Monitoring during Cardiac Surgery , 1994, Anesthesiology.

[26]  M. Kedaria,et al.  Jugular bulb oxygen saturation during propofol and isoflurane/nitrous oxide anesthesia in patients undergoing brain tumor surgery. , 1999, Anesthesia and analgesia.

[27]  M. Pinaud,et al.  Effects of propofol on cerebral hemodynamics and metabolism in patients with brain trauma. , 1990, Anesthesiology.

[28]  Effects of a diazepam-fentanyl mixture on cerebral blood flow and oxygen consumption in man. , 1978, British journal of anaesthesia.