Pharmacokinetic analyses with rugfit an interactive pharmacokinetic computer program

RUGFIT is an interactive computer program to fit polyexponential equations to experimental points without the need of assumptions about the number of exponential terms and without the need of initial parameter estimates. The fitting is performed by iterative stripping minimizing the sum of squared residuals. This procedure leads to multiple model equations describing the profile of the y‐value in time, that are compared with the test of Boxenbaum et al.