A family study of the association of increased ventricular size with schizophrenia.

Families with more than one individual of the same generation with the diagnosis of schizophrenia were recruited for studies. Brain lateral ventricular size was quantified in 26 schizophrenic subjects from 12 unrelated families, their available well siblings (N = 10), and 20 nonpsychotic controls. Lateral ventricular size was significantly greater in the schizophrenics than in their well siblings and controls. In addition, an analysis of variance of the data showed a significant familial component to ventricular size. Although histories of head injury and birth complications were also associated with ventricular size, these were not sufficient to explain both the familial aspect of ventricular size and the association of greater ventricular size with schizophrenia within these families.

[1]  J. Endicott,et al.  [Schedule for Affective Disorders and Schizophrenia (SADS)]. , 1987, Acta psychiatrica Belgica.

[2]  M. Reveley,et al.  Schizophrenia with Good and Poor Outcome II: Cerebral Ventricular Size and its Clinical Significance , 1985, British Journal of Psychiatry.

[3]  M. Baron,et al.  Platelet monoamine oxidase activity and genetic vulnerability to schizophrenia. , 1984, The American journal of psychiatry.

[4]  S. Mednick,et al.  Cerebral ventricular size in the offspring of schizophrenic mothers. A preliminary study. , 1984, Archives of general psychiatry.

[5]  A. Reveley,et al.  Cerebral Ventricular Enlargement in Non-Genetic Schizophrenia: a Controlled Twin Study , 1984, British Journal of Psychiatry.

[6]  K. Kendler,et al.  Overview: a current perspective on twin studies of schizophrenia. , 1983, The American journal of psychiatry.

[7]  S. Kuperman,et al.  Clinical differences between schizophrenic patients with and without large cerebral ventricles. , 1983, The Journal of clinical psychiatry.

[8]  R. Murray,et al.  Genetics of Platelet MAO Activity in Discordant Schizophrenic and Normal Twins , 1983, British Journal of Psychiatry.

[9]  D. Weinberger,et al.  Neuropathological studies of schizophrenia: a selective review. , 1983, Schizophrenia bulletin.

[10]  Richard J. Haier,et al.  Schizophrenia: The epigenetic puzzle Cambridge University Press, Cambridge (1982). 258 pp. by Irving I. Gottesman and James Shields , 1982, Psychiatry Research.

[11]  A. Reveley,et al.  CEREBRAL VENTRICULAR SIZE IN TWINS DISCORDANT FOR SCHIZOPHRENIA , 1982, The Lancet.

[12]  R. Wyatt,et al.  Measurement of premorbid adjustment in chronic schizophrenia. , 1982, Schizophrenia bulletin.

[13]  R. Grossman,et al.  Ventricular enlargement after closed head injury. , 1981, Archives of neurology.

[14]  T. Crow,et al.  Platelet Monoamine Oxidase Activity in Acute Schizophrenia: Relationship to Symptomatology and Neuroleptic Medication , 1981, British Journal of Psychiatry.

[15]  L. DeLisi,et al.  Familial aspects of CT scan abnormalities in chronic schizophrenic patients , 1981, Psychiatry Research.

[16]  R J Wyatt,et al.  Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia. , 1980, The American journal of psychiatry.

[17]  B. Jacobsen,et al.  Perinatal complications in adopted and non‐adopted schizophrenics and their controls: Preliminary results , 1980 .

[18]  T. Crow,et al.  Molecular pathology of schizophrenia: more than one disease process? , 1980, British medical journal.

[19]  D. Weinberger,et al.  Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. , 1979, Archives of general psychiatry.

[20]  C. Mazure,et al.  Blindness and reliability in lifetime psychiatric diagnosis. , 1979, Archives of general psychiatry.

[21]  D. Weinberger,et al.  CEREBELLAR ATROPHY IN CHRONIC SCHIZOPHRENIA , 1979, The Lancet.

[22]  E. Gershon,et al.  Genetic strategies in biological psychiatry. , 1978, Archives of general psychiatry.

[23]  T. Crow,et al.  PLATELET MONAMINE OXIDASE IN SCHIZOPHRENIA , 1977, The Lancet.

[24]  R. Ebstein,et al.  PLATELET MONOAMINE OXIDASE IN SCHIZOPHRENIA , 1977, The Lancet.

[25]  M. Krawiecka,et al.  A standardized psychiatric assessment scale for rating chronic psychotic patients , 1977, Acta psychiatrica Scandinavica.

[26]  T. Crow,et al.  Platelet monamine oxidase in schizophrenia. An investigation in drug-free chronic hospitalized patients. , 1976, Archives of general psychiatry.

[27]  T. Crow,et al.  CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA , 1976, The Lancet.

[28]  V. Synek,et al.  The ventricular-brain ratio using planimetric measurement of EMI scans. , 1976, The British journal of radiology.

[29]  D. Murphy,et al.  Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia , 1973, Science.

[30]  Haug Jo.  Pneumoencephalographic studies in mental disease. , 1962 .

[31]  E. Hillbom.  After-effects of brain-injuries. Research on the symptoms causing invalidism of persons in Finland having sustained brain-injuries during the wars of 1939-1940 and 1941-1944. , 1960, Acta psychiatrica Scandinavica. Supplementum.