NOVEL TETRACYCLINE DERIVATIVES PRODUCEDBY A Dactylosporangium sp . I . TAXONOMY , PRODUCTION , ISOLATION AND BIOLOGICAL ACTIVITY

A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occuring tetracycline C2 amides which lack cross resistance with tetracycline.

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