Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States)

AURKA is an important protein in the regulation of G2 to M transition during mitosis. Due to this regulatory function, it has been hypothesized to be a potential cancer susceptibility gene. Two non-synonymous polymorphisms (F31I and V57I) have been associated with breast cancer risk in prior studies. We sought to confirm these findings in a large case control study nested within a prospective cohort, the Nurses' Health Study. Post-menopausal women who were homozygous for the 31I and 57V alleles had an increased risk of invasive breast cancer (OR 1.63, 95% CI 1.08–2.45). We also performed a meta-analysis to summarize the findings of this and prior studies of association between the F31I polymorphism and breast cancer risk (Summary OR 1.29, 95% CI 1.08–1.53, p-heterogeneity = 0.29). These results confirm prior findings that AURKA represents a low penetrance breast cancer susceptibility gene.

[1]  Hiroki Nagase,et al.  Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human , 2003, Nature Genetics.

[2]  Erich A. Nigg,et al.  Centrosome aberrations: cause or consequence of cancer progression? , 2002, Nature Reviews Cancer.

[3]  M. Kimura,et al.  STK 15 polymorphism and breast cancer risk in a population-based study , 2004 .

[4]  Chen-Yang Shen,et al.  Breast cancer risk associated with genotypic polymorphism of the mitosis‐regulating gene Aurora‐A/STK15/BTAK , 2005, International journal of cancer.

[5]  STK15 polymorphism and breast cancer risk in a population-based study. , 2004, Carcinogenesis.

[6]  A. Balmain,et al.  Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. , 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[7]  Jian Kuang,et al.  Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation , 1998, Nature Genetics.

[8]  S. Lippman,et al.  Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[9]  W. Tan,et al.  Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma. , 2004, Carcinogenesis.