Linkage methods in human genetics before the computer

Apart from sex linkage, we know almost nothing at present of linkage in man. Yet it is certain that every defect determined by a single factor must be located in one or other of twenty-three [sic] linkage groups. Each defect must therefore be linked in inheritance with numerous other observable traits, and with some of them is probably linked closely. The search for such linkage will certainly be lengthy, and at first, disappointing. (R.A. Fisher. Eugenics, academic and practical. Eugenics Review, 27, pp. 95–100, 1935c)

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