A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins

[1]  H. Nakagama,et al.  Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving β-catenin, c-Myc and E2F1 , 2007, Oncogene.

[2]  R. Sears,et al.  Negative regulation of Pim-1 protein kinase levels by the B56β subunit of PP2A , 2007, Oncogene.

[3]  F. Tsai,et al.  Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. , 2007, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.

[4]  Peter J. Mohler,et al.  Molecular basis for PP2A regulatory subunit B56α targeting in cardiomyocytes , 2007 .

[5]  H. Döhner,et al.  Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B. , 2007, European journal of cancer.

[6]  Angus C Nairn,et al.  Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56δ subunit , 2007, Proceedings of the National Academy of Sciences.

[7]  Xin Cai,et al.  A specific PP2A regulatory subunit, B56γ, mediates DNA damage‐induced dephosphorylation of p53 at Thr55 , 2007, The EMBO journal.

[8]  S. McMahon,et al.  BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-induced Apoptosis* , 2007, Journal of Biological Chemistry.

[9]  Yigong Shi,et al.  Structure of the Protein Phosphatase 2A Holoenzyme , 2006, Cell.

[10]  W. Hahn,et al.  Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. , 2006, Cell.

[11]  R. Sears,et al.  Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias , 2006, Leukemia.

[12]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[13]  Xingming Deng,et al.  Protein Phosphatase 2A Enhances the Proapoptotic Function of Bax through Dephosphorylation* , 2006, Journal of Biological Chemistry.

[14]  Fengqin Gao,et al.  Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival , 2006, Molecular and Cellular Biology.

[15]  J. Yu,et al.  Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells. , 2006, International journal of molecular medicine.

[16]  R. Sears,et al.  Protein Phosphatase 2A Regulatory Subunit B56α Associates with c-Myc and Negatively Regulates c-Myc Accumulation , 2006, Molecular and Cellular Biology.

[17]  K. Arihiro,et al.  Alterations and correlations of the components in the Wnt signaling pathway and its target genes in breast cancer. , 2005, Oncology reports.

[18]  H. Clevers,et al.  Wnt signalling in stem cells and cancer , 2005, Nature.

[19]  J. Woodgett,et al.  The links between axin and carcinogenesis , 2005, Journal of Clinical Pathology.

[20]  J. St-Germain,et al.  B56 Regulatory Subunit of Protein Phosphatase 2A Mediates Valproic Acid-Induced p300 Degradation , 2005, Molecular and Cellular Biology.

[21]  S. Korsmeyer,et al.  Antiapoptotic BCL-2 is required for maintenance of a model leukemia. , 2004, Cancer cell.

[22]  J. Darbon,et al.  Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit , 2004, Biology of the cell.

[23]  William R Sellers,et al.  The biology and clinical relevance of the PTEN tumor suppressor pathway. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[24]  K. Nakayama,et al.  Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7 , 2004, The EMBO journal.

[25]  B. Clurman,et al.  The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Y. Kitamura,et al.  A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance. , 2004, Histology and histopathology.

[27]  Joseph R. Nevins,et al.  A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells , 2004, Nature Cell Biology.

[28]  T. Goi,et al.  PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers. , 2004, Oncology reports.

[29]  J. Vermeesch,et al.  Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. , 2004, Journal of molecular biology.

[30]  C. van Hoof,et al.  PP2A fulfills its promises as tumor suppressor: which subunits are important? , 2004, Cancer cell.

[31]  W. Hahn,et al.  Identification of specific PP2A complexes involved in human cell transformation. , 2004, Cancer cell.

[32]  Fengqin Gao,et al.  Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[33]  V. Centonze,et al.  PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. , 2003, Molecular cell.

[34]  P. S. Klein,et al.  PP2A:B56ϵ is required for Wnt/β-catenin signaling during embryonic development , 2003 .

[35]  Cindy L. Kanies,et al.  Protein Phosphatase 2A Dephosphorylation of Phosphoserine 112 Plays the Gatekeeper Role for BAD-Mediated Apoptosis , 2003, Molecular and Cellular Biology.

[36]  Y. Kitamura,et al.  Localization of the PP2A B56gamma regulatory subunit at the Golgi complex: possible role in vesicle transport and migration. , 2003, The American journal of pathology.

[37]  R. Dahiya,et al.  Beta-catenin mutations correlate with over expression of C-myc and cyclin D1 Genes in bladder cancer. , 2002, The Journal of urology.

[38]  John L Cleveland,et al.  c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. , 2002, Genes & development.

[39]  Fengqin Gao,et al.  A Functional Role for the B56 α-Subunit of Protein Phosphatase 2A in Ceramide-mediated Regulation of Bcl2 Phosphorylation Status and Function* , 2002, The Journal of Biological Chemistry.

[40]  Xinghai Li,et al.  B56-Associated Protein Phosphatase 2A Is Required For Survival and Protects from Apoptosis in Drosophila melanogaster , 2002, Molecular and Cellular Biology.

[41]  S. Nomoto,et al.  ΔNp63 induces β-catenin nuclear accumulation and signaling , 2002 .

[42]  S. Thorgeirsson,et al.  Cyclin G recruits PP2A to dephosphorylate Mdm2. , 2002, Molecular cell.

[43]  Robert A. Weinberg,et al.  Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation , 2002, Molecular and Cellular Biology.

[44]  K. Rundell,et al.  Critical role for SV40 small-t antigen in human cell transformation. , 2001, Virology.

[45]  J. Cleveland,et al.  Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1 , 2001, Oncogene.

[46]  Mitsutoshi Nakamura,et al.  Reduced expression of the Aα subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aα and Aβ subunit genes , 2001 .

[47]  A. Schönthal,et al.  Role of serine/threonine protein phosphatase 2A in cancer. , 2001, Cancer letters.

[48]  H. Yost,et al.  Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus , 2001, The EMBO journal.

[49]  M. Roussel,et al.  Apoptosis Triggered by Myc-Induced Suppression of Bcl-XL or Bcl-2 Is Bypassed during Lymphomagenesis , 2001, Molecular and Cellular Biology.

[50]  J. Hancock,et al.  Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions , 2001, Oncogene.

[51]  L. Ashworth,et al.  Absence of PPP2R1A mutations in Wilms tumor , 2001, Oncogene.

[52]  A. Nakagawara,et al.  Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[53]  K. Rundell,et al.  The role of the SV40 ST antigen in cell growth promotion and transformation. , 2001, Seminars in cancer biology.

[54]  Huong T. T. Pham,et al.  Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aα subunit gene , 2001, Oncogene.

[55]  Robert E. Johnson,et al.  Requirement of DNA Polymerase η for Error-Free Bypass of UV-Induced CC and TC Photoproducts , 2001, Molecular and Cellular Biology.

[56]  J. Stock,et al.  Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits , 2000, The EMBO journal.

[57]  Y Taya,et al.  Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. , 2000, Genes & development.

[58]  W. Kolch,et al.  Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation* , 2000, The Journal of Biological Chemistry.

[59]  R. Goodman,et al.  CBP/p300 in cell growth, transformation, and development. , 2000, Genes & development.

[60]  D. Virshup,et al.  Protein phosphatase 2A: a panoply of enzymes. , 2000, Current opinion in cell biology.

[61]  G. Russo,et al.  Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms , 2000, Oncogene.

[62]  H Nojima,et al.  A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation , 2000, The EMBO journal.

[63]  Zhen Yan,et al.  PR48, a Novel Regulatory Subunit of Protein Phosphatase 2A, Interacts with Cdc6 and Modulates DNA Replication in Human Cells , 2000, Molecular and Cellular Biology.

[64]  Yoshiyuki Kuchino,et al.  Regulation of c-Myc through Phosphorylation at Ser-62 and Ser-71 by c-Jun N-Terminal Kinase* , 1999, The Journal of Biological Chemistry.

[65]  D. Felsher,et al.  Reversible tumorigenesis by MYC in hematopoietic lineages. , 1999, Molecular cell.

[66]  E. Prochownik,et al.  MYC oncogenes and human neoplastic disease , 1999, Oncogene.

[67]  G. Prendergast,et al.  Mechanisms of apoptosis by c-Myc , 1999, Oncogene.

[68]  B. Hemmings,et al.  Regulation of protein kinase cascades by protein phosphatase 2A. , 1999, Trends in biochemical sciences.

[69]  G. Evan,et al.  Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. , 1999, Molecular cell.

[70]  B. Wadzinski,et al.  Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. , 1999, The Biochemical journal.

[71]  Raymond L. White,et al.  Regulation of β-Catenin Signaling by the B56 Subunit of Protein Phosphatase 2A , 1999 .

[72]  J. Nevins,et al.  Ras enhances Myc protein stability. , 1999, Molecular cell.

[73]  A. Schönthal,et al.  Role of PP2A in intracellular signal transduction pathways. , 1998, Frontiers in bioscience : a journal and virtual library.

[74]  K. Scheidtmann,et al.  Protein phosphatase 2A is required for the initiation of chromosomal DNA replication. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[75]  J. Minna,et al.  Alterations of the PPP2R1B gene in human lung and colon cancer. , 1998, Science.

[76]  C. Busch,et al.  myc Boxes, Which Are Conserved in myc Family Proteins, Are Signals for Protein Degradation via the Proteasome , 1998, Molecular and Cellular Biology.

[77]  A. Sparks,et al.  Identification of c-MYC as a target of the APC pathway. , 1998, Science.

[78]  Paul Polakis,et al.  Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β , 1998, Current Biology.

[79]  L. Williams,et al.  Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription , 1998 .

[80]  Akira Kikuchi,et al.  Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin , 1998 .

[81]  R. Parsons.  Phosphatases and tumorigenesis , 1998, Current opinion in oncology.

[82]  E. Kremmer,et al.  Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells , 1997, Molecular and cellular biology.

[83]  A. Berns,et al.  Complementation tagging of cooperating oncogenes in knockout mice. , 1996, Seminars in cancer biology.

[84]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.

[85]  M. Loda,et al.  CDC25 phosphatases as potential human oncogenes. , 1995, Science.

[86]  M. Mumby.  Regulation by tumour antigens defines a role for PP2A in signal transduction. , 1995, Seminars in cancer biology.

[87]  B. Lutterbach,et al.  Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis , 1994, Molecular and cellular biology.

[88]  B. Hemmings,et al.  The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. , 1994, The Journal of biological chemistry.

[89]  M. Mumby,et al.  The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation , 1993, Cell.

[90]  J. Stock,et al.  Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase. , 1993, The Journal of biological chemistry.

[91]  S. Clarke,et al.  Methyl esterification of C-terminal leucine residues in cytosolic 36-kDa polypeptides of bovine brain. A novel eucaryotic protein carboxyl methylation reaction. , 1993, The Journal of biological chemistry.

[92]  A. Bradley,et al.  A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. , 1993, Genes & development.

[93]  Brian A. Hemmings,et al.  The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase , 1993, Cell.

[94]  R. Davis,et al.  Signal transduction within the nucleus by mitogen-activated protein kinase. , 1992, The Journal of biological chemistry.

[95]  J. Chen,et al.  Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. , 1992, Science.

[96]  B. Zheng,et al.  Mitotic arrest and enhanced nuclear protein phosphorylation in human leukemia K562 cells by okadaic acid, a potent protein phosphatase inhibitor and tumor promoter. , 1991, The Journal of biological chemistry.

[97]  H. Fujiki,et al.  Promotion of BALB/3T3 Cell Transformation by the Okadaic Acid Class of Tumor Promoters, Okadaic Acid and Dinophysistoxin‐1 , 1991, Japanese journal of cancer research : Gann.

[98]  R. Eisenman,et al.  New light on Myc and Myb. Part II. Myb. , 1990, Genes & development.

[99]  A. Strasser,et al.  Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2 , 1990, Nature.

[100]  T. B. Miller,et al.  Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A , 1990, Cell.

[101]  M. Cole,et al.  Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences , 1987, Molecular and cellular biology.

[102]  M. Cole,et al.  Constitutive c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but not commitment , 1986, Nature.

[103]  P. Leder,et al.  Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor , 1983, Cell.

[104]  Peter J Mohler,et al.  Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes. , 2007, American journal of physiology. Heart and circulatory physiology.

[105]  Robert J. White,et al.  RNA polymerases I and III, growth control and cancer , 2005, Nature Reviews Molecular Cell Biology.

[106]  P. S. Klein,et al.  PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic development. , 2003, Development.

[107]  S. Nomoto,et al.  DeltaNp63 induces beta-catenin nuclear accumulation and signaling. , 2002, Cancer cell.

[108]  D. Pallas,et al.  Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. , 2001, Molecular biology of the cell.

[109]  P. Kleihues,et al.  Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes. , 2001, International journal of cancer.

[110]  W. May,et al.  Phosphorylation of Bcl2 and regulation of apoptosis , 2001, Leukemia.

[111]  P. Ruvolo.  Ceramide regulates cellular homeostasis via diverse stress signaling pathways , 2001, Leukemia.

[112]  G. Russo,et al.  Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms. , 2000, Oncogene.

[113]  R. Moon,et al.  Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. , 1999, Science.

[114]  P. Polakis,et al.  Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. , 1998, Current biology : CB.

[115]  A. Kikuchi,et al.  Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. , 1998, The EMBO journal.

[116]  L. Williams,et al.  Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[117]  J. Woodgett,et al.  Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo. , 1994, Oncogene.

[118]  S. Shenolikar,et al.  Protein serine/threonine phosphatases--new avenues for cell regulation. , 1994, Annual review of cell biology.

[119]  R. Eisenman,et al.  New light on Myc and Myb. Part I. Myc. , 1990, Genes & development.

[120]  T. Sugimura,et al.  Role of protein phosphatases in malignant transformation. , 1989, Princess Takamatsu symposia.

[121]  M. Cole.  The myc oncogene: its role in transformation and differentiation. , 1986, Annual review of genetics.