Protective Role of Onion (Allium cepa L.) on Caffeine Induced Spermatotoxicity in Albino Rats

Onion is widely consumed and is used for several medicinal and therapeutic purposes such as management of diabetes and also as antimutagenic, antimicrobial and antioxidant agents. Hence, this study investigated the protective role of onion on caffeine induced spermatotoxicity in albino rats as mammalian model. Thirty healthy male albino rats of 12 weeks old were divided into five groups with six rats in each group using a completely randomized design (CRD). The daily caffeine and onion juice treatments were administered orally via oral gavage for sixty five days. Result obtained indicated a significant (P<0.05) reduction in the weight of epididymes, sperm viability, sperm motility and sperm count while sperm head abnormality increased in caffeine-treated animals. No significant differences were observed in semen pH and weight of testes. Onion juice protected mammalian model from caffeine induced toxicities on the weight of testes, sperm viability, sperm motility, sperm count and sperm head abnormality. These results show that onion is effective in protecting albino rat models against caffeine induced spermatotoxicity in a dose dependent manner.

[1]  M. Faiq,et al.  Oxidative stress and male infertility , 2017, Nature Reviews Urology.

[2]  U. B. Ekaluo,et al.  In vitro Antioxidant and Free Radical Activity of Some Nigerian Medicinal Plants: Bitter Leaf (Vernonia amygdalina L.) and Guava (Psidium guajava Del.) , 2015 .

[3]  I. Daniel,et al.  Attenuating Potential of Trevo Dietary Supplement on Caffeine Induced Sperm Toxicities in Albino Rats , 2015 .

[4]  U. B. Ekaluo,et al.  Comparative in vitro Assessment of Drumstick (Moringa oleifera) and Neem (Azadiracta indica) Leaf Extracts for Antioxidant and Free Radical Scavenging Activities , 2015 .

[5]  U. B. Ekaluo,et al.  Attenuating Role of Vitamin C on Sperm Toxicity Induced by Monosodium Glutamate in Albino Rats , 2013 .

[6]  U. B. Ekaluo,et al.  Effect of Soursop (Annona muricata L.) Fruit Extract on Sperm Toxicity Induced by Caffeine in Albino Rats , 2013 .

[7]  O. Yama,et al.  Effects of Tahitian Noni dietary supplement on caffeine-induced testicular histo-pathological alterations in adult Sprague-Dawley rats , 2011 .

[8]  M. Nouri,et al.  Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat. , 2009, Folia morphologica.

[9]  U. B. Ekaluo,et al.  Sperm head abnormality and mutagenic effects of aspirin, paracetamol and caffeine containing analgesics in rats , 2008 .

[10]  U. B. Ekaluo,et al.  Effect of chloroquine treatments on sperm count and weight of testes in male rats , 2008 .

[11]  A. Abu-Aita,et al.  Impact of vitamin C on genotoxicity , sperm abnormalities and serum biochemical alterations in deltamethrin exposed rats , 2008 .

[12]  A. Olmer,et al.  Caffeinism: History, Clinical Features, Diagnosis, and Treatment , 2006 .

[13]  J. Kluger.  The buzz on caffeine. , 2004, Time.

[14]  B. Thomas,et al.  Onions—A global benefit to health , 2002, Phytotherapy research : PTR.

[15]  Andrew P. Smith,et al.  Effects of caffeine on human behavior. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[16]  S. Sikka,et al.  Characterization of reactive oxygen species induced effects on human spermatozoa movement and energy metabolism. , 1999, Free radical biology & medicine.

[17]  B. Fredholm,et al.  Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. , 1999, Pharmacological reviews.

[18]  Jorge D. Pamplona Roger,et al.  Encyclopedia of medicinal plants , 1998 .

[19]  R. Everson,et al.  Use of fluorescence in situ hybridization (FISH) to assess effects of smoking, caffeine, and alcohol on aneuploidy load in sperm of healthy men , 1997, Environmental and molecular mutagenesis.

[20]  Z. El-Gohary,et al.  Hormonal and histological effects of chronic caffeine administration on the pituitary-gonadal and pituitary-adrenocortical axes in male rabbits. , 1994, Functional and developmental morphology.

[21]  R. Christianson,et al.  CAFFEINATED BEVERAGES AND DECREASED FERTILITY , 1989, The Lancet.